Zhi-Xiu Lin

TL;DR: It is shown that brusatol provokes a rapid and transient depletion of Nrf2 protein, through a posttranscriptional mechanism, in mouse Hepa-1c1c7 hepatoma cells, substantiate brusatols as a useful experimental tool for the inhibition of NRF2 signaling and highlight the potential for therapeutic inhibition ofNrf2 to alter the risk of adverse events by reducing the capacity of nontarget cells to buffer against chemical and oxidative insults.

TL;DR: Results indicate that baicalein prevented PC12 cells from 6-OHDA-induced oxidative damage via the activation of Keap1/Nrf2/HO-1, and it also involves the PKCα and PI3K/AKT signaling pathway.

TL;DR: The results suggest that PA possesses potent anti-inflammatory activity, which may be mediated, at least in part, by down-regulating the mRNA expression of a panel of inflammatory mediators including TNF-α, IL-1β, iNOS and COX-2.

TL;DR: One new compound, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, and twenty-eight known phenolic compounds were isolated, showing a great potential for their development as effective natural tyrosinase inhibitors.

TL;DR: The results showed the potential of deformable liposomes to enhance the anti-UVB effects of Qu both in vitro and in vivo.