Qin Zhu

TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.

TL;DR: Results suggest that an activation of some antioxidant enzymes was enhanced to counteract the oxidative stress induced by the two metals.

TL;DR: One new compound, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, and twenty-eight known phenolic compounds were isolated, showing a great potential for their development as effective natural tyrosinase inhibitors.

TL;DR: A 2.4-A-resolution X-ray crystal structure of the carrier-protein-independent halogenase WelO5 in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipated site of the oxo group in a presumptive cis-halo-oxo-iron(IV) (haloferryl) intermediate.

TL;DR: A 42 kbp ambiguine (amb) biosynthetic gene cluster that harbors 32 protein-coding genes in its native producer Fischerella ambigua UTEX1903 is identified and suggests late-stage C-H activations are likely responsible for the structural diversities of ambiguines by regio- and stereospecific chlorination, hydroxylation, epoxidation, and sp(2)-sp(3) C-C bond formation.