Z
Zhigang Zhang
Researcher at Shanghai Jiao Tong University
Publications - 335
Citations - 13480
Zhigang Zhang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 48, co-authored 281 publications receiving 9429 citations. Previous affiliations of Zhigang Zhang include Chongqing University & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak.
Tao Zhang,Qunfu Wu,Zhigang Zhang +2 more
TL;DR: Genomic and evolutionary evidence of the occurrence of a SARS-CoV-2-like CoV (named Pangolin-Cov) in dead Malayan pangolins is found and suggests that pangolin species are a natural reservoir of SARS
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γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer
Pin Wu,Dang Wu,Chao Ni,Jun Ye,Wuzhen Chen,Guoming Hu,Zhen Wang,Changrong Wang,Zhigang Zhang,Wenjie Xia,Zhigang Chen,Ke Wang,Tao Zhang,Jinghong Xu,Yuehua Han,Ting Zhang,Xianguo Wu,Jianwei Wang,Weihua Gong,Shu Zheng,Fuming Qiu,Jun Yan,Jian Huang +22 more
TL;DR: This study uncovers an inf-DC-γδT17-PMN-MDSC regulatory axis in human CRC that correlates MDSC-meditated immunosuppression with tumor-elicited inflammation.
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Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.
Hua Xiong,Zhigang Zhang,Xiao Qing Tian,Dan Feng Sun,Qin Chuan Liang,Yanjie Zhang,Rong Lu,Ying Xuan Chen,Jing-Yuan Fang +8 more
TL;DR: The results demonstrate that STAT3 and both JAK1 and 2 are involved in CRC cell growth, survival, invasion, and migration through regulation of gene expression, such as Bcl-2, p1(6ink4a), p21(waf1/cip 1), p27(kip1), E-cadherin, VEGF, and MMPs.
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Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study
Qiujin Shen,Jia Fan,Xin-Rong Yang,Yexiong Tan,Weifeng Zhao,Yang Xu,Ning Wang,Yongdong Niu,Zheng Wu,Jian Zhou,Shuang-Jian Qiu,Ying-Hong Shi,Bin Yu,Ning Tang,Wei Chu,Min Wang,Jinhua Wu,Zhigang Zhang,Yang Shengli,Jianren Gu,Hongyang Wang,Hongyang Wang,Wenxin Qin +22 more
TL;DR: DKK1 could complement measurement of AFP in the diagnosis of HCC and improve identification of patients with AFP-negative H CC and distinguish HCC from non-malignant chronic liver diseases.
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Phylogenomic reconstruction of lactic acid bacteria: an update.
TL;DR: It is inferred that the occurrence of multiple, independent adaptation events in LAB species, have resulted in their occupation of various habitats and the phylogenetic utility of several genes are revealed.