Showing papers in "Neoplasia in 2008"

TL;DR: The results support previous work suggesting that TMPRSS2-ERG fusions mediate invasion, consistent with the defining histologic distinction between PIN and prostate cancer, and suggest that it may not be sufficient for transformation in the absence of secondary molecular lesions.

TL;DR: The results demonstrate that STAT3 and both JAK1 and 2 are involved in CRC cell growth, survival, invasion, and migration through regulation of gene expression, such as Bcl-2, p1(6ink4a), p21(waf1/cip 1), p27(kip1), E-cadherin, VEGF, and MMPs.

TL;DR: There is evidence that other, more common mechanisms besides gene inversion exist including the possibility of other fusion partners for ALK and EML4, and the NKX2-1 high-level amplification was confirmed in a significant subset of NSCLC and found this amplification to be mutually exclusive to ALk and E ML4 rearrangements.

TL;DR: PIK3CA mutation is significantly associated with other key molecular events in colorectal cancer, and MGMT loss likely contributes to the development of Pik3CA G>A mutation, and Pyrosequencing is useful in detecting PIK3 CA mutation in archival paraffin tumor tissue.

TL;DR: A mechanism whereby CCL2 attracts proangiogenic CCR2(+) macrophages with the ancillary capability to limit infiltration by neutrophils is suggested, providing alternative paracrine support for tumor angiogenesis and progression.

TL;DR: High-level expression of all three HDACs is associated with a poor prognosis in ovarian endometrioid carcinomas, and the independent prognostic information and the overall high rate of expression for class IHDACs suggest that these targets should be explored as predictive factors in ovarian and endometrial carcinomas prospectively.

TL;DR: It is demonstrated that the addition of ErbB2 inhibition leads to a persistent phosphorylation of ERK1/2, which negatively regulates the downstream signaling and cell growth, suggesting a mechanism for the cross-talk involving the ERK pathway.

TL;DR: This work presents the first demonstration that merlin regulates cell growth in human cancer cells by suppressing YAP, the mammalian homolog of Yorkie, in meningiomas.

TL;DR: It is concluded that microvesicle shedding is a major secretory pathway for cathepsin B release from tumor cells, and the acidic microenvironment found in most solid tumors may contribute to cathePSin B-mediated proinvasive capabilities of tumor-shed vesicles.

TL;DR: The data suggest that tumor cells promote their growth by exploiting A(2B) adenosine receptor-dependent regulation of VEGF in host immune cells.

TL;DR: Measuring PDGFA, bFGF, and HIF1a expression may contribute to a better understanding of the prognosis of patients with pancreatic cancer and may even play a crucial role for the distribution of patients to multimodal therapeutic regimens.

TL;DR: Results of these studies show that CXCL5 protein expression levels are concordant with prostate tumor progression, are highly associated with inflammatory infiltrate, and are frequently detected in the lumens of both benign and malignant prostate glands.

TL;DR: The genomic alterations revealed in this study provide an important catalog of positional information relevant to efforts aimed at deciphering the molecular genetic basis of prostate cancer.

TL;DR: The hypothesis that demethylating agents also demethylate and activate genes involved in invasion and metastasis and therefore might increase the risk of developing tumor metastasis is tested.

TL;DR: It is reported that bevacizumab, which is an antiangiogenic drug with a different mechanism of action, could be useful in combination with temozolomide to increase the latter's therapeutic benefit in glioma patients.

TL;DR: It is demonstrated that FZD7 activates the canonical Wnt pathway in colon cancer cells despite the presence of APC or CTNNB1 mutation and that FzD7-siRNA may be used as a therapeutic reagent for CRCs.

TL;DR: Increased Cdc7-Dbf4 abundance may be a common occurrence in human malignancies and a high correlation between p53 loss and increased CDC7 and DBF4 expression in primary breast cancers is found.

TL;DR: In this article, the authors investigated HIF-1α, c-Myc, pAkt, and aerobic glycolysis in low-passage breast cancer cells under the assumption that these represent the in vivo condition better than established lines.

TL;DR: Tumors resected after therapy showed that etaracizumab treatment reduced the proliferating cell nuclear antigen index but not microvessel density, which defines the Akt pathway as a predictor of response to function-blocking antibody.

TL;DR: It is concluded that the ligation of α2β1 by collagen I activates RhoC guanosine triphosphatase, which mediates PCa invasion, and suggests a mechanism for the preferential metastasis of PCa cells within the bone.

TL;DR: Glioblastoma patients who do not respond to chemotherapy and whose tumors over-express NaK alpha1 subunits could benefit from a treatment using ligands with marked binding affinity for the NaKalpha1 subunit.

TL;DR: The results imply that HERV-K-T47D-RT might be expressed in early malignancy and might serve as a novel prognostic marker for breast cancer and provide evidence for the possible involvement of endogenous retrovirus in human breast carcinoma.

TL;DR: The significant increase in the cure of tumor-bearing mice in the nab-paclitaxel/bevacizumab combined group compared with mice treated with single drugs strongly advocates for implementing such strategy in clinics.

TL;DR: It is demonstrated that in HNSCC cell lines, the expression of the phosphorylated forms of the mTOR downstream targets S6 kinase and S6 (pS6) decreased after hypoxia, and it is found that the reduced mTOR activity in response to Hypoxia through AMPK/REDD1 was deregulated, which hence might contribute to the persistent activation of themTOR pathway in this cancer type.

TL;DR: The initial findings indicate that NIR/US using %BVI can be used during chemotherapy to repeatedly monitor tumor vascular changes and may evaluate pathologic response during treatment allowing for tailoring therapies to response.

TL;DR: It is shown that increased receptor stability and sustained FGFR-4 signaling occur in most human prostate cancers due to either the presence of a common genetic polymorphism or the expression of a protein that stabilizes FG FR-4.

TL;DR: It is shown that this cell-permeable, small-molecule compound inhibits furin-mediated cleavage of proMT1-MMP, resulting in decreased MMP-2 activation and cell motility in CHO cells expressing proMT 1-M MP.

TL;DR: Evaluated stem/tumor-initiating cells in the model of the mouse mammary neoplasia driven by the activated form of rat Her-2/neu oncogene indicate a Sca-1(+) population derived from mammary BALB-neuT tumors is responsible for sphere generation in culture and for initiating tumors in vivo.

TL;DR: It is demonstrated that fascin is expressed in a panel of human malignant glioma cell lines, and downregulation of fascin expression in gli cancer cell lines by small interfering RNA (siRNA) is associated with decreased cellular attachment to extracellular matrix (ECM) and reduced migration.

TL;DR: Interestingly, mutations that lead to the alteration of the stem cell division pattern or the acquisition of some degree of immortality in committed progenitors lead to an early onset of cancer and diminish the impact of genetic instability.