Z
Zhili Zuo
Researcher at Chinese Academy of Sciences
Publications - 88
Citations - 1555
Zhili Zuo is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virtual screening & Docking (molecular). The author has an hindex of 20, co-authored 80 publications receiving 1247 citations. Previous affiliations of Zhili Zuo include Singapore Polytechnic & Sichuan University of Science and Engineering.
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Journal ArticleDOI
Gambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain
Yu-xin Qin,Linghua Meng,Chaoxin Hu,Wenhu Duan,Zhili Zuo,Liping Lin,Xiong-Wen Zhang,Jian Ding +7 more
TL;DR: The results reported here show that GA exerts its antiproliferative effect by inhibiting the catalytic activity Topo IIα, and indicate that GA inhibits TopO IIα-mediated DNA cleavage and modulate the activity of Topo I poisons, which provide rationale for further clinical evaluation of GA.
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Melokhanines A–J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus
Gui-Guang Cheng,Dan Li,Bo Hou,Xiao-Nian Li,Lu Liu,Ying-Ying Chen,Paul-Keilah Lunga,Afsar Khan,Afsar Khan,Ya-Ping Liu,Zhili Zuo,Xiao-Dong Luo +11 more
TL;DR: Alkaloids 1-16, 25-27, 31, and 32 showed the best antibacterial activity against Pseudomonas aeruginosa and among the seven dermatophytes tested, compound 1 showed significant inhibitory activity against Microsporum canis, M. ferrugineum, and Trichophyton ajelloi.
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Discovery of Novel Small Molecule Inhibitors of Dengue Viral NS2B-NS3 Protease Using Virtual Screening and Scaffold Hopping
Jing Deng,Ning Li,Hongchuan Liu,Zhili Zuo,Oi Wah Liew,Weijun Xu,Gang Chen,Xiankun Tong,Wei Tang,Jin Zhu,Jianping Zuo,Hualiang Jiang,Hualiang Jiang,Cai-Guang Yang,Jian Li,Weiliang Zhu +15 more
TL;DR: 17 new compounds were discovered as NS2B-NS3 protease inhibitors with IC(50) values of 7.46 ± 1.15 to 48.59 ± 3.46 μM, and 8 compounds belonging to two different scaffolds are active to some extent against DENV based on luciferase reporter replicon-based assays.
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Antitumor Research on Artemisinin and Its Bioactive Derivatives
TL;DR: This review concentrated on the new advances and development of artemisinin and its derivatives as potential antitumor agents in recent 5 years and it is hoped that this review could be helpful for further exploration of novel art Artemisinin-related antitumour agents.
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Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear.
Feng-Jiao Zhou,Feng-Jiao Zhou,Yin Nian,Yong-Ming Yan,Ye Gong,Qi Luo,Yu Zhang,Bo Hou,Zhili Zuo,Shu-Mei Wang,He-Hai Jiang,Jian Yang,Jian Yang,Yong-Xian Cheng +13 more
TL;DR: Biological evaluation found that compounds (+)-1, (-)-3, and (±)-6 significantly inhibited Cav3.1 TTCC and showed noticeable selectivity against Cav1.2, Cav2.1, and Kv11.1 (hERG) channels.