Z
Zhiqi Sun
Researcher at Max Planck Society
Publications - 24
Citations - 2333
Zhiqi Sun is an academic researcher from Max Planck Society. The author has contributed to research in topics: Integrin & Cell adhesion. The author has an hindex of 10, co-authored 16 publications receiving 1771 citations. Previous affiliations of Zhiqi Sun include Tsinghua University.
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Journal ArticleDOI
Integrin-mediated mechanotransduction.
TL;DR: Sun, Guo, and Fässler review the function and regulation of integrin-mediated mechanotransduction and discuss how its dysregulation impacts cancer progession.
Journal ArticleDOI
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments.
Herbert B. Schiller,Michaela-Rosemarie Hermann,Julien Polleux,Timothée Vignaud,Sara Zanivan,Caroline C. Friedel,Zhiqi Sun,Aurelia Raducanu,Kay-E. Gottschalk,Manuel Théry,Matthias Mann,Reinhard Fässler +11 more
TL;DR: This study assigns specific functions to distinct fibronectin-binding integrins, demonstrating that α5β1integrins accomplish force generation, whereas αv-class Integrins mediate the structural adaptations to forces, which cooperatively enable cells to sense the rigidity of fibronECTin-based microenvironments.
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Integrin activation by talin, kindlin and mechanical forces
TL;DR: The current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity is discussed, and how integrin inactivators function in this framework.
Journal ArticleDOI
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites
Jingyi Gong,Zhiqi Sun,Lizhen Wu,Wenyi Xu,Nicole L. Schieber,Dijin Xu,Guanghou Shui,Hongyuan Yang,Robert G. Parton,Peng Li +9 more
TL;DR: The lipid Droplet–associated protein Fsp27 mediates lipid droplet growth by promoting directional lipid transfer from smaller to larger lipid droplets.
Journal ArticleDOI
Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes
Zhiqi Sun,Jingyi Gong,Han Wu,Wenyi Xu,Lizhen Wu,Dijin Xu,Jinlan Gao,Jia-Wei Wu,Hongyuan Yang,Maojun Yang,Peng Li +10 more
TL;DR: Perilipin1 (Plin1), another adipocyte-specific lipid droplet-associated protein, is identified as an Fsp27 activator and can restore the activity of CIDE-N homodimerization-defective mutants of Fsp 27, uncovering a novel mechanism underlying lipid Droplet growth and unilocular lipid droplets formation.