Zhuang Liu

TL;DR: A bioinspired nanosystem of cancer cell membrane-camouflaged SPIO@DOX-ICG nanoparticles was fabricated to realize precise cancer treatment by simultaneous chemotherapy, hyperthermia-therapy, and radiotherapy and achieved synergistic anticancer effects by antagonizing tumor hypoxia and reprograming the polarization of tumor associated macrophages to anti-tumor M1 phenotype.

TL;DR: This work presents a new concept of applying nanotechnology in RIT, by delivering radioisotopes into tumors, self-sensitizing the irradiation-induced cell damage, and modulating the tumor hypoxia state to further enhance the therapeutic outcomes.

TL;DR: A small luciferase protein was conjugated to QDs as a bioluminescence resonance energy transfer (BRET) pair and the self-illuminating QD-Nluc showed excellent energy transfer in a living system and offered an optimal tumor-to-background ratio (>85).

TL;DR: It is discovered that H2 gas in hydrogen-chemotherapy can inhibit mitochondrial function, hinder ATP synthesis, and cause the reduction of P-gp efflux pump function, which finally attenuate P- gp protein drug transport capacity in cancer cells.

TL;DR: In this article, the authors summarized the strategies of MnO2 and its nanocomposites to modulate TME, such as tumor hypoxia relief, excessive glutathione (GSH) depletion, glucose consumption, and tumor immunosuppressive microenvironment moderation.