Zi-Xuan Wang

TL;DR: It is reported here that DARC is indeed expressed in endothelial cells lining postcapillary venules and splenic sinusoids in individuals who lack the erythrocyte receptor, and the DARC may play a critical role in mediating the effects of proinflammatory chemokines on the interactions between leukocyte and endothelial Cells.

TL;DR: Immunohistochemical examination of human archival sections of the brain with monoclonal antibodies specific for DARC localize expression of DARC to cell bodies and processes of Purkinjie cells in the cerebellum and suggests that chemokines may play an important role in the modulation of neuronal activity by glial cells.

TL;DR: These experiments demonstrate that progression from the R5 to X4 phenotype may occur through a multi- or dual-tropic intermediate and that multiple domains contribute to this process.

TL;DR: It is demonstrated that sequences in the third hypervariable region determine the specificity of coreceptor utilization for fusion, and that a conserved motif in the crown directly influences the molecular anatomy of the interaction between gp120 and CCR5.

TL;DR: It is suggested that the molecular anatomy of CCR5 binding plays a critical role in antagonism of coreceptor activity and monoclonal antibodies to N-ter epitopes did not block chemokine binding, but those mapped to ECL2 were effective inhibitors.