Regulation of the voltage gated K channel Kv1.3 by recombinant human klotho protein.
Ahmad Almilaji,Sabina Honisch,Guilai Liu,Bernat Elvira,Sumant Singh Ajay,Zohreh Hosseinzadeh,Musaab Ahmed,Carlos Munoz,Mentor Sopjani,Florian Lang +9 more
TLDR
The present study explored the impact of alpha Klotho protein on the voltage gated K+ channel Kv1.3 currents and protein abundance in Jcam lymphoma cells, an effect depending on its β-glucuronidase activity.Abstract:
Background/Aims: Klotho, a protein mainly produced in the kidney and released into circulating blood, contributes to the negative regulation of 1,25(OH)2read more
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Klotho , stem cells, and aging
TL;DR: The klotho protein was shown to suppress Wnt-signaling transduction, and inhibit cell senescence and preserve stem cells, and may be a promising therapeutic agent for aging and aging-related disorders.
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Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury
TL;DR: Klotho is enriched in macrophages and Klotho preservation by Rhein attenuates lipopolysaccharide (LPS)-induced acute inflammation essentially via promoting toll-like receptor 4 (TLR4) degradation and possesses promising potentials in the clinical treatment of renal inflammatory disorders.
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Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations
TL;DR: In this paper , the authors demonstrate that two types of state-dependent activity, rapid arousal/movement-related signals and a 3-5 Hz alpha-like rhythm, in the primary visual cortex (V1) of mice strongly correlate with activity in the visual thalamus.
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The Role of Janus Kinase 3 in the Regulation of Na+/K+ ATPase under Energy Depletion
Zohreh Hosseinzadeh,Sabina Honisch,Evi Schmid,Kashif Jilani,Kalina Szteyn,Shefalee K. Bhavsar,Yogesh Singh,Monica Palmada,Anja T. Umbach,Ekaterina Shumilina,Florian Lang +10 more
TL;DR: JAK3 down-regulates Na-ATPase activity, an effect involving gene expression and profoundly curtailing ATP consumption, in dendritic cells (DCs) of JAK3-knockout mice.
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Stretchable Mesh Nanoelectronics for 3D Single‐Cell Chronic Electrophysiology from Developing Brain Organoids
TL;DR: A cyborg brain organoid platform is reported, in which “tissue‐like” stretchable mesh nanoelectronics are designed to match the mechanical properties of brain organoids and to be folded by the organogenetic process of progenitor or stem cells, distributing stretchable electrode arrays across the 3D organoids.
References
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Journal ArticleDOI
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.
TL;DR: The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches.
Journal ArticleDOI
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,Hiroki Aizawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,Hitoshi Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Ryozo Nagai,Yo-ichi Nabeshima +16 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, including short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema as mentioned in this paper.
Journal ArticleDOI
Liquid junction potentials and small cell effects in patch-clamp analysis.
Peter H. Barry,Joseph W. Lynch +1 more
TL;DR: The aim of this review is to outline the contribution of such junction potentials and the errors resulting from measurements on small cells and to indicate how adequate junction potential corrections can be applied and the true values of underlying membrane parameters determined for such cells.
Journal ArticleDOI
The ß-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel
Qing Chang,S.J.G. Hoefs,J.W.C.M. van der Kemp,Catalin N. Topala,René J. M. Bindels,Joost G. J. Hoenderop +5 more
TL;DR: It is reported here that TRPV5 is stimulated by the mammalian hormone klotho, which activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides and maintains durable calcium channel activity and membrane calcium permeability in kidney.