Acadia University

About: Acadia University is a education organization based out in Wolfville, Nova Scotia, Canada. It is known for research contribution in the topics: Population & Wireless sensor network. The organization has 1903 authors who have published 3881 publications receiving 90517 citations. The organization is also known as: Queen's College.

Comparative Mitochondrial Genomics of Freshwater Mussels (Bivalvia: Unionoida) With Doubly Uniparental Inheritance of mtDNA: Gender-Specific Open Reading Frames and Putative Origins of Replication

Abstract: Doubly uniparental inheritance (DUI) of mitochondrial DNA in marine mussels (Mytiloida), freshwater mussels (Unionoida), and marine clams (Veneroida) is the only known exception to the general rule of strict maternal transmission of mtDNA in animals. DUI is characterized by the presence of gender-associated mitochondrial DNA lineages that are inherited through males (male-transmitted or M types) or females (female-transmitted or F types), respectively. This unusual system constitutes an excellent model for studying basic aspects of mitochondrial DNA inheritance and the evolution of mtDNA genomes in general. Here we compare published mitochondrial genomes of unionoid bivalve species with DUI, with an emphasis on characterizing unassigned regions, to identify regions of the F and M mtDNA genomes that could (i) play a role in replication or transcription of the mtDNA molecule and/or (ii) determine whether a genome will be transmitted via the female or the male gamete. Our results reveal the presence of one F-specific and one M-specific open reading frames (ORFs), and we hypothesize that they play a role in the transmission and/or gender-specific adaptive functions of the M and F mtDNA genomes in unionoid bivalves. Three major unassigned regions shared among all F and M unionoid genomes have also been identified, and our results indicate that (i) two of them are potential heavy-strand control regions (OH) for regulating replication and/or transcription and that (ii) multiple and potentially bidirectional light-strand origins of replication (OL) are present in unionoid F and M mitochondrial genomes. We propose that unassigned regions are the most promising candidate sequences in which to find regulatory and/or gender-specific sequences that could determine whether a mitochondrial genome will be maternally or paternally transmitted.

A Longitudinal Study of Mother-Child Relationships and Theory of Mind in the Preschool Period

Abstract: To investigate individual differences in theory of mind acquisition, this study examined whether different aspects of early mother-child relationships contributed to the development of false belief understanding at the close of the preschool period. Forty-six mother and child pairs were seen when children were two and again at five years of age. At age two, home-based Q-sort observations of attachment security and maternal sensitivity were made, and mothers completed a number of self-report measures to create an aggregate of maternal emotional distress. At age five, attachment security and maternal distress were reassessed, and false belief tasks were administered that were based on unexpected identities and locations of objects. In addition, attachment-relevant false belief tasks involving separation from caregivers were also used, which children found significantly more difficult than tasks involving objects. Age five security predicted object location task performance. Maternal sensitivity and emotional distress at age two predicted later caregiver location task performance, even controlling for age five measures. These results support a growing literature on the importance of relationship processes and parenting context to theory of mind acquisition.

Investigating the time course of spoken word recognition: Electrophysiological evidence for the influences of phonological similarity

Abstract: Behavioral and modeling evidence suggests that words compete for recognition during auditory word identification, and that phonological similarity is a driving factor in this competition. The present study used event-related potentials (ERPs) to examine the temporal dynamics of different types of phonological competition (i.e., cohort and rhyme). ERPs were recorded during a novel picture-word matching task, where a target picture was followed by an auditory word that either matched the target (CONE-cone), or mismatched in one of three ways: rhyme (CONE-bone), cohort (CONE-comb), and unrelated (CONE-fox). Rhymes and cohorts differentially modulated two distinct ERP components, the phonological mismatch negativity and the N400, revealing the influences of prelexical and lexical processing components in speech recognition. Cohort mismatches resulted in late increased negativity in the N400, reflecting disambiguation of the later point of miscue and the combined influences of top-down expectations and misleading bottom-up phonological information on processing. In contrast, we observed a reduction in the N400 for rhyme mismatches, reflecting lexical activation of rhyme competitors. Moreover, the observed rhyme effects suggest that there is an interaction between phoneme-level and lexical-level information in the recognition of spoken words. The results support the theory that both levels of information are engaged in parallel during auditory word recognition in a way that permits both bottom-up and top-down competition effects.

The Eco-Scalar Fix: Rescaling Environmental Governance and the Politics of Ecological Boundaries in Alberta, Canada

Abstract: This paper engages with recent work in political ecology that explores the ways in which scale is imbricated in environmental governance. Specifically, we analyze the deployment of specific ecological scales as putatively �natural� governance units in rescaling processes. To undertake this analysis, the paper brings two sets of literature into dialogue: (1) political ecology of scale and (2) political economy of rescaling, drawing on theories of uneven development. Building on this literature, we develop the concept of an eco-scalar fix and explore its analytical potential through a case study of the rescaling of water governance in Alberta, Canada. We argue that although the �eco-scalar fix� is usually framed as an apolitical governance change�particularly through the framing of particular scales (ie, the watershed) as �natural��it is often, in fact, a deeply political move that reconfigures power structures and prioritizes some resource uses over others in ways that can entrench, rather than resolve, the crises it was designed to address. Moreover, we suggest that, although watershed governance is often discursively depicted as an environmental strategy (eg, internalizing environmental externalities by aligning decision making with ecological boundaries), it is often articulated with�and undertaken to address challenges that arise through�processes of uneven development.

Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer.

Abstract: Recently, an intense attention has been paid to the application of natural compounds as a novel therapeutic strategy for cancer treatment. Quercetin, a natural flavonol present in many commonly consumed food items, is widely demonstrated to exert inhibitory effects on cancer progression through various mechanisms. Since there is a strong association with diets containing abundant vegetables, fruits, and grains, and significant decline in the risk of colon cancer, accumulation studies have focused on the anticancer potential of quercetin in colorectal cancer. Cell cycle arrest, increase in apoptosis, antioxidant replication, modulation of estrogen receptors, regulation of signaling pathways, inhibition of and metastasis and angiogenesis are among various mechanisms underlying the chemo-preventive effects of quercetin in colorectal cancer. This review covers various therapeutic interactions of Quercetin as to how targets cellular involved in cancer treatment.