American Pharmacists Association

About: American Pharmacists Association is a other organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Pharmacist & Pharmacy. The organization has 2413 authors who have published 1969 publications receiving 30470 citations. The organization is also known as: APhA & American Pharmaceutical Association.

Guidelines on Implementing Antimicrobial Stewardship Programs in Korea

Abstract: These guidelines were developed as a part of the 2021 Academic R&D Service Project of the Korea Disease Control and Prevention Agency in response to requests from healthcare professionals in clinical practice for guidance on developing antimicrobial stewardship programs (ASPs). These guidelines were developed by means of a systematic literature review and a summary of recent literature, in which evidence-based intervention methods were used to address key questions about the appropriate use of antimicrobial agents and ASP expansion. These guidelines also provide evidence of the effectiveness of ASPs and describe intervention methods applicable in Korea.

Shake table tests on clutter levels of typical medicine shelves and contents subjected to earthquakes

Abstract: Overturned shelves and fallen objects scattered on floors are one of the most frequently observed forms of nonstructural damage after earthquakes. The term ‘clutter’ is adopted in this study to represent this type of damage. Clutter may cause obstructions and thus hinder the use of a room. Making a seismic evaluation of clutter is a daunting task, due to the diversity of the types of shelves and objects and the way the objects are stored. Nonetheless, in order to achieve performance-based seismic evaluation, especially for critical facilities such as hospitals, it is reasonable to undertake the estimation of clutter when examining the association between the performance of structural and nonstructural elements. Of particular interest in this paper is clutter caused by objects stored on medicine shelves in pharmacies, which are one of the critical departments for delivering post-earthquake emergency care. Shake table tests were conducted on three conventional types of medicine shelves. Sinusoidal waves and earthquake motions were input uniaxially. The results of the tests using the sinusoidal wave input indicated the relationship between the input excitation intensity and clutter level expressed in scattering distance from the front of the shelf. Tests using earthquake motion input were then conducted and the results were compared with those for sinusoidal waves. Based on a comparison of the results from these tests, criteria for the seismic evaluation of clutter caused by medicine shelves due to earthquakes were proposed. Copyright © 2011 John Wiley & Sons, Ltd.

Sexual dysfunction and clomipramine.

Abstract: Three cases of orgasmic inhibition by clomipramine are reported, one in a male and two in females. All were depressed patients with obsessive-compulsive features. Orgasmic dysfunction manifested shortly after beginning clomipramine therapy despite a return of libido as the depression lifted. Two of these patients switched to desipramine which led to a resolution of sexual dysfunction while maintaining the patients depression free. The third patient manipulated dosage times to diminish the orgastic problem. Strong anticholinergic and/or anti-adrenergic properties of clomipramine are suspected to underlie the development of this problem.

First-line disease-modifying therapies in paediatric multiple sclerosis: a comprehensive overview.

Abstract: Paediatric multiple sclerosis (MS) is defined as the onset of MS before the age of 18 years. Immunomodulatory disease-modifying therapies (i.e. the interferons [IFNs] and glatiramer acetate) are considered first-line treatments in adult patients with MS, but they are largely understudied in the paediatric population.

Enfuvirtide: A Novel Agent for the Treatment of HIV-1 Infection

Abstract: ObjectiveTo review the pharmacology, virology, pharmacokinetics, efficacy, safety, and clinical use of enfuvirtide.Data SourcesEnglish-language MEDLINE and AIDSline searches were performed (1966–January 2003) using enfuvirtide, T-20, gp41, and fusion inhibitors as key words. Abstracts from infectious diseases and HIV scientific meetings were identified.Data ExtractionAll publications and meeting abstracts were reviewed and relevant items included. In vitro and preclinical studies were included, as well as Phase II and III clinical trials.Data SynthesisEnfuvirtide is a fusion inhibitor used for the treatment of HIV-1 infection. Given its unique mechanism of action, most HIV-1 isolates are susceptible to enfuvirtide. Enfuvirtide is administered by subcutaneous injection twice daily. In clinical trials with antiretroviral-experienced patients, enfuvirtide was effective at suppressing HIV-RNA and increasing CD4+ T-cell counts. Enfuvirtide should be used in combination with other active antiretroviral agents t...