ARPA-E

About: ARPA-E is a government organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Population & Climate change. The organization has 1161 authors who have published 1267 publications receiving 30049 citations. The organization is also known as: Advanced Research Projects Agency - Energy.

Comparison of different exposure settings in a case–crossover study on air pollution and daily mortality: counterintuitive results

Abstract: Comparison of different exposure settings in a case–crossover study on air pollution and daily mortality: counterintuitive results

A geostatistical approach to define guidelines for radon prone area identification

Abstract: Radon is a natural radioactive gas known to be the main contributor to natural background radiation exposure and the major leading cause of lung cancer second to smoking. Indoor radon concentration levels of 200 and 400 Bq/m3 are reference values suggested by the 90/143/Euratom recommendation, above which mitigation measures should be taken in new and old buildings, respectively, to reduce exposure to radon. Despite this international recommendation, Italy still does not have mandatory regulations or guidelines to deal with radon in dwellings. Monitoring surveys have been undertaken in a number of western European countries in order to assess the exposure of people to this radioactive gas and to identify radon prone areas. However, such campaigns provide concentration values in each single dwelling included in the sample, while it is often necessary to provide measures of the pollutant concentration which refer to sub-areas of the region under study. This requires a realignment of the spatial data from the level at which they are collected (points) to the level at which they are necessary (areas). This is known as change of support problem.In this paper, we propose a methodology based on geostatistical simulations in order to solve this problem and to identify radon prone areas which may be suggested for national guidelines.

Mild Developmental Foreign Accent Syndrome and Psychiatric Comorbidity: Altered White Matter Integrity in Speech and Emotion Regulation Networks

Abstract: Foreign accent syndrome (FAS) is a speech disorder that is defined by the emergence of a peculiar manner of articulation and intonation which is perceived as foreign. In most cases of acquired FAS (AFAS) the new accent is secondary to small focal lesions involving components of the bilaterally distributed neural network for speech production. In the past few years FAS has also been described in different psychiatric conditions (conversion disorder, bipolar disorder, and schizophrenia) as well as in developmental disorders (specific language impairment, apraxia of speech). In the present study, two adult males, one with atypical phonetic production and the other one with cluttering, reported having developmental FAS (DFAS) since their adolescence. Perceptual analysis by naive judges could not confirm the presence of foreign accent, possibly due to the mildness of the speech disorder. However, detailed linguistic analysis provided evidence of prosodic and segmental errors previously reported in AFAS cases. Cognitive testing showed reduced communication in activities of daily living and mild deficits related to psychiatric disorders. Psychiatric evaluation revealed long-lasting internalizing disorders (neuroticism, anxiety, obsessive-compulsive disorder, social phobia, depression, alexithymia, hopelessness, and apathy) in both subjects. Diffusion tensor imaging (DTI) data from each subject with DFAS were compared with data from a group of 21 age- and gender-matched healthy control subjects. Diffusion parameters (MD, AD, and RD) in predefined regions of interest showed changes of white matter microstructure in regions previously related with AFAS and psychiatric disorders. In conclusion, the present findings militate against the possibility that these two subjects have FAS of psychogenic origin. Rather, our findings provide evidence that mild DFAS occurring in the context of subtle, yet persistent, developmental speech disorders may be associated with structural brain anomalies. We suggest that the simultaneous involvement of speech and emotion regulation networks might result from disrupted neural organization during development, or compensatory or maladaptive plasticity. Future studies are required to examine whether the interplay between biological trait-like diathesis (shyness, neuroticism) and the stressful experience of living with mild DFAS lead to the development of internalizing psychiatric disorders.