Capital Medical University

About: Capital Medical University is a education organization based out in Beijing, China. It is known for research contribution in the topics: Population & Medicine. The organization has 56150 authors who have published 47290 publications receiving 811249 citations.

Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study

Abstract: Summary Background China has a large population of older people, but has not yet undertaken a comprehensive study on the prevalence, risk factors, and management of both dementia and mild cognitive impairment (MCI). Methods For this national cross-sectional study, 46 011 adults aged 60 years or older were recruited between March 10, 2015, and Dec 26, 2018, using a multistage, stratified, cluster-sampling method, which considered geographical region, degree of urbanisation, economic development status, and sex and age distribution. 96 sites were randomly selected in 12 provinces and municipalities representative of all socioeconomic and geographical regions in China. Participants were interviewed to obtain data on sociodemographic characteristics, lifestyle, medical history, current medications, and family history, and then completed a neuropsychological testing battery administered by a psychological evaluator. The prevalence of dementia (Alzheimer's disease, vascular dementia, and other dementias) and MCI were calculated and the risk factors for different groups were examined using multivariable-adjusted analyses. Findings Overall age-adjusted and sex-adjusted prevalence was estimated to be 6·0% (95% CI 5·8–6·3) for dementia, 3·9% (3·8–4·1) for Alzheimer's disease, 1·6% (1·5–1·7) for vascular dementia, and 0·5% (0·5–0·6) for other dementias. We estimated that 15·07 million (95% CI 14·53–15·62) people aged 60 years or older in China have dementia: 9·83 million (9·39–10·29) with Alzheimer's disease, 3·92 million (3·64–4·22) with vascular dementia, and 1·32 million (1·16–1·50) with other dementias. Overall MCI prevalence was estimated to be 15·5% (15·2–15·9), representing 38·77 million (37·95–39·62) people in China. Dementia and MCI shared similar risk factors including old age (dementia: odds ratios ranging from 2·69 [95% CI 2·43–2·98] to 6·60 [5·24–8·32]; MCI: from 1·89 [1·77–2·00] to 4·70 [3·77–5·87]); female sex (dementia: 1·43 [1·31–1·56]; MCI: 1·51 [1·43–1·59]); parental history of dementia (dementia: 7·20 [5·68–9·12]; MCI: 1·91 [1·48–2·46]); rural residence (dementia: 1·16 [1·06–1·27]; MCI: 1·45 [1·38–1·54]); fewer years of education (dementia: from 1·17 [1·06–1·29] to 1·55 [1·38–1·73]; MCI: from 1·48 [1·39–1·58] to 3·48 [3·25–3·73]); being widowed, divorced, or living alone (dementia: from 2·59 [2·30–2·90] to 2·66 [2·29–3·10]; MCI: from 1·58 [1·44–1·73] to 1·74 [1·56–1·95]); smoking (dementia: 1·85 [1·67–2·04]; MCI: 1·27 [1·19–1·36]), hypertension (dementia: 1·86 [1·70–2·03]; MCI: 1·62 [1·54–1·71] for MCI), hyperlipidaemia (dementia: 1·87 [1·71–2·05]; MCI: 1·29 [1·21–1·37]), diabetes (dementia: 2·14 [1·96–2·34]; MCI: 1·44 [1·35–1·53]), heart disease (dementia: 1·98 [1·73–2·26]; MCI: 1·17 [1·06–1·30]), and cerebrovascular disease (dementia: 5·44 [4·95–5·97]; MCI: 1·49 [1·36–1·62]). Nine of these risk factors are modifiable. Interpretation Dementia and MCI are highly prevalent in China and share similar risk factors. A prevention strategy should be developed to target the identified risk factors in the MCI population to thwart or slow down disease progression. It is also crucial to optimise the management of dementia and MCI as an important part of China's public health system. Funding Key Project of the National Natural Science Foundation of China, National Key Scientific Instrument and Equipment Development Project, Mission Program of Beijing Municipal Administration of Hospitals, Beijing Scholars Program, Beijing Brain Initiative from Beijing Municipal Science & Technology Commission, Project for Outstanding Doctor with Combined Ability of Western and Chinese Medicine, and Beijing Municipal Commission of Health and Family Planning.

A novel approach of consultation on 2019 novel coronavirus (COVID-19)-related psychological and mental problems: Structured letter therapy

Abstract: A Novel Approach of Consultation on 2019 Novel Coronavirus (COVID-19)-Related Psychological and Mental Problems: Structured Letter Therapy

Prevalence and Outcomes of Symptomatic Intracranial Large Artery Stenoses and Occlusions in China: The Chinese Intracranial Atherosclerosis (CICAS) Study

Abstract: Background and Purpose— We aimed to establish the prevalence, characteristics, and outcomes of intracranial atherosclerosis (ICAS) in China by a large, prospective, multicenter study. Methods— We evaluated 2864 consecutive patients who experienced an acute cerebral ischemia <7 days after symptom onset in 22 Chinese hospitals. All patients underwent magnetic resonance angiography, with measurement of diameter of the main intracranial arteries. ICAS was defined as ≥50% diameter reduction on magnetic resonance angiography. Results— The prevalence of ICAS was 46.6% (1335 patients, including 261 patients with coexisting extracranial carotid stenosis). Patients with ICAS had more severe stroke at admission and stayed longer in hospitals compared with those without intracranial stenosis (median National Institutes of Health Stroke Scale score, 3 versus 5; median length of stay, 14 versus 16 days; both P <0.0001). After 12 months, recurrent stroke occurred in 3.27% of patients with no stenosis, in 3.82% for those with 50% to 69% stenosis, in 5.16% for those with 70% to 99% stenosis, and in 7.27% for those with total occlusion. Cox proportional hazards regression analyses showed that the degree of arterial stenosis, age, family history of stroke, history of cerebral ischemia or heart disease, complete circle of Willis, and National Institutes of Health Stroke Scale score at admission were independent predictors for recurrent stroke at 1 year. The highest rate of recurrence was observed in patients with occlusion with the presence of ≥3 additional risk factors. Conclusions— ICAS is the most common vascular lesion in patients with cerebrovascular disease in China. Recurrent stroke rate in our study was lower compared with those of previous clinical trials but remains unacceptably high in a subgroup of patients with severe stenosis.

Parcellating cortical functional networks in individuals

Abstract: The capacity to identify the unique functional architecture of an individual's brain is a crucial step toward personalized medicine and understanding the neural basis of variation in human cognition and behavior. Here we developed a cortical parcellation approach to accurately map functional organization at the individual level using resting-state functional magnetic resonance imaging (fMRI). A population-based functional atlas and a map of inter-individual variability were employed to guide the iterative search for functional networks in individual subjects. Functional networks mapped by this approach were highly reproducible within subjects and effectively captured the variability across subjects, including individual differences in brain lateralization. The algorithm performed well across different subject populations and data types, including task fMRI data. The approach was then validated by invasive cortical stimulation mapping in surgical patients, suggesting potential for use in clinical applications.