Institution
Capital Medical University
Education•Beijing, China•
About: Capital Medical University is a education organization based out in Beijing, China. It is known for research contribution in the topics: Population & Medicine. The organization has 56150 authors who have published 47290 publications receiving 811249 citations.
Topics: Population, Medicine, Stroke, Cancer, Randomized controlled trial
Papers published on a yearly basis
Papers
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TL;DR: A marked elevation of the BGL confirms the diagnosis of diabetes, including a random plasma glucose concentration ≥11.1 mmol/L (200 mg/dl) or fasting plasma glucose ≥7.0 mmol/l (≥126 mg/DL) in the presence of overt symptoms.
Abstract: Diagnostic criteria for all types of diabetes in children and adolescents are based on laboratory measurement of plasma glucose levels (BGL) and the presence or absence of symptoms (E). Finger prick BGL testing should not be used to diagnose diabetes (E). A marked elevation of the BGL confirms the diagnosis of diabetes, including a random plasma glucose concentration ≥11.1 mmol/L (200 mg/dl) or fasting plasma glucose ≥7.0 mmol/l (≥126 mg/dl) in the presence of overt symptoms. This article is protected by copyright. All rights reserved.
389 citations
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TL;DR: Results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques, and this has key implications for public health and economic initiatives if validated in human studies.
Abstract: Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It is unclear whether convalescing patients have a risk of reinfection. We generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. Comparing the humoral and cellular immunity between primary infection and rechallenge revealed notably enhanced neutralizing antibody and immune responses. Our results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques.
385 citations
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Peking University1, Second Military Medical University2, Chinese Academy of Sciences3, Capital Medical University4, University of Science and Technology of China5, Southern University of Science and Technology6, Harbin Institute of Technology7, Sun Yat-sen University8, Peking Union Medical College9, Third Military Medical University10, Guangzhou Medical University11, Beijing Normal University12, Shantou University13, Wuhan University14, Huazhong University of Science and Technology15, Shanghai Jiao Tong University16, Chinese PLA General Hospital17, Fudan University18, Guangzhou Institutes of Biomedicine and Health19
TL;DR: In this article, the authors applied single-cell RNA sequencing to 284 samples from 196 COVID-19 patients and controls and created a comprehensive immune landscape with 1.46 million cells.
385 citations
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TL;DR: TH cytokine levels, eosinophilic/neutrophilic patterns, and SE-specific IgE expressions show extreme diversity among patients with CRS from Europe, Asia, and Oceania.
Abstract: Background To date, no study has evaluated the diversity of T H cell cytokine patterns of patients with chronic rhinosinusitis (CRS) among centers in different continents using identical methods. Objective We sought to assess T H cytokine profiles in patients with CRS from Europe, Asia, and Australia. Methods Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP; n = 435) and control subjects (n = 138) were recruited from centers in Adelaide, Benelux, Berlin, Beijing, Chengdu, and Tochigi. Nasal mucosal concentrations of T H 2, T H 17, and T H 1 cytokines; eosinophilic cationic protein (ECP); myeloperoxidase (MPO); IL-8; and tissue total and Staphylococcus aureus enterotoxin (SE)–specific IgE were measured by using identical tools. Results Combinations of T H 1/T H 2/T H 17 cytokine profiles in patients with CRSwNP varied considerably between regions. CRSwNP tissues from patients from Benelux, Berlin, Adelaide, and Tochigi were T H 2 biased, whereas those from Beijing mainly demonstrated T H 2/T H 1/T H 17 mixed patterns, and patients from Chengdu showed an even lower T H 2 expression. Concentrations of IL-8 and tissue total IgE in patients with CRSwNP were significantly higher than those in control subjects in all regions. More than 50% of patients with CRSwNP in Benelux, Berlin, Adelaide, and Tochigi showed a predominantly eosinophilic endotype compared with less than 30% of patients in Beijing and Chengdu. SE-specific IgE was found in significantly greater numbers in patients with CRSwNP from Benelux, Adelaide, and Tochigi and significantly lower numbers in patients from Beijing and Chengdu. Moreover, the T H 1/T H 2/T H 17 cytokine profiles in patients with CRSsNP showed diversity among the 6 regions. Conclusion T H cytokine levels, eosinophilic/neutrophilic patterns, and SE-specific IgE expressions show extreme diversity among patients with CRS from Europe, Asia, and Oceania.
383 citations
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TL;DR: Concern is aroused that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs.
Abstract: Nano materials generate great benefits as well as new potential risks. Animal studies and in vitro experiments show that nanoparticles can result in lung damage and other toxicity, but no reports on the clinical toxicity in humans due to nanoparticles have yet been made. The present study aimed to examine the relationship between a group of workers' presenting with mysterious symptomatic findings and their nanoparticle exposure. Seven young female workers (aged 18-47 yrs), exposed to nanoparticles for 5-13 months, all with shortness of breath and pleural effusions were admitted to hospital. Immunological tests, examinations of bacteriology, virology and tumour markers, bronchoscopy, internal thoracoscopy and video-assisted thoracic surgery were performed. Surveys of the workplace, clinical observations and examinations of the patients were conducted. Polyacrylate, consisting of nanoparticles, was confirmed in the workplace. Pathological examinations of patients' lung tissue displayed nonspecific pulmonary inflammation, pulmonary fibrosis and foreign-body granulomas of pleura. Using transmission electron microscopy, nanoparticles were observed to lodge in the cytoplasm and caryoplasm of pulmonary epithelial and mesothelial cells, but are also located in the chest fluid. These cases arouse concern that long-term exposure to some nanoparticles without protective measures may be related to serious damage to human lungs.
381 citations
Authors
Showing all 56323 results
Name | H-index | Papers | Citations |
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Yang Yang | 171 | 2644 | 153049 |
Hua Zhang | 163 | 1503 | 116769 |
Matthias Egger | 152 | 901 | 184176 |
Jost B. Jonas | 132 | 1158 | 166510 |
Shuai Liu | 129 | 1095 | 80823 |
Yang Liu | 129 | 2506 | 122380 |
Chao Zhang | 127 | 3119 | 84711 |
Michael Wang | 117 | 1428 | 56282 |
Wei Lu | 111 | 1973 | 61911 |
Yan Zhang | 107 | 2410 | 57758 |
Claus Bachert | 106 | 842 | 49557 |
Nan Lin | 105 | 687 | 54545 |
Banglin Chen | 105 | 393 | 55287 |
Ming Li | 103 | 1669 | 62672 |
George F. Gao | 102 | 793 | 82219 |