Institution
Catholic University of Daegu
Education•Gyeongsan-si, South Korea•
About: Catholic University of Daegu is a education organization based out in Gyeongsan-si, South Korea. It is known for research contribution in the topics: Population & Apoptosis. The organization has 2745 authors who have published 5670 publications receiving 80311 citations.
Topics: Population, Apoptosis, Cancer, Signal transduction, MAPK/ERK pathway
Papers published on a yearly basis
Papers
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TL;DR: In this article, the tube diameter effect on hydroformability was investigated for a member with complex section of vehicle bumper rail, and four types of loading paths for minimizing thinning were identified.
49 citations
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TL;DR: The HSA-TRAIL conjugate, which presents clear advantages of targeting RA and long systemic circulation by HSA and unique anti-inflammatory efficacy by TRAIL, has potential as a novel treatment for rheumatoid arthritis.
49 citations
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TL;DR: Serum uric acid level could be considered an important risk factor for arterial stiffness in Korean population, whereas carotid IMT is not associated with serum uric Acid in either gender when using data from the Korean Multi-Rural Communities Cohort study.
48 citations
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TL;DR: It is found that SRT1720 treatment ameliorated cisplatin-induced acute renal failure and histopathological alterations and showed that the therapeutic effects of S RT1720 were associated with reduced acetylation of p53 and nuclear factor kappa-B p65 and preservation of peroxisome function, as evidenced by recovered expression of markers for number and function of peroxideisome.
Abstract: Sirtuin 1 (Sirt1) is an essential modulator of cellular metabolism and has pleiotropic effects. It was recently reported that Sirt1 overexpression in kidney tubule ameliorates cisplatin-induced acute kidney injury (AKI). However, whether pharmacological activation of Sirt1 also has a beneficial effect against the disease remains unclear. In this study, we aimed to evaluate whether SRT1720, a potent and specific activator of Sirt1, could ameliorate cisplatin-induced AKI. We found that SRT1720 treatment ameliorated cisplatin-induced acute renal failure and histopathological alterations. Increased levels of tubular injury markers in kidneys were significantly attenuated by SRT1720. SRT1720 treatment also suppressed caspase-3 activation and apoptotic cell death. Increased expression of 4-hydroxynonenal, elevated malondialdehyde level, and decreased ratio of reduced glutathione/oxidized glutathione after cisplatin injection were significantly reversed by SRT1720. In addition, SRT1720 treatment decreased renal expression of pro-inflammatory cytokines and prevented macrophage infiltration into damaged kidneys. We also showed that the therapeutic effects of SRT1720 were associated with reduced acetylation of p53 and nuclear factor kappa-B p65 and preservation of peroxisome function, as evidenced by recovered expression of markers for number and function of peroxisome. These results suggest that Sirt1 activation by SRT1720 would be a useful therapeutic option for cisplatin-induced AKI.
48 citations
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TL;DR: The fractionated fucoidan strongly stimulated murine macrophages, producing a considerable amount of nitric oxide and inducing expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and interleukin-10 (IL-10) transcripts by activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) pathways.
48 citations
Authors
Showing all 2758 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jon Zubieta | 79 | 820 | 29114 |
KiHwan Bae | 50 | 276 | 8235 |
M. A. Rao | 49 | 173 | 7792 |
Young Hag Koh | 47 | 178 | 6924 |
Heung Soo Kim | 46 | 372 | 10036 |
Maria Teresa Voso | 46 | 283 | 6815 |
Byung Sun Min | 43 | 385 | 7465 |
Hyo-Jin Kim | 40 | 394 | 6606 |
MinKyun Na | 39 | 233 | 5004 |
Young-Chae Chang | 37 | 172 | 4838 |
In-Seon Lee | 35 | 197 | 4170 |
Hyo Seon Park | 35 | 185 | 4648 |
Beom Soo Shin | 34 | 139 | 3250 |
Kwan-Kyu Park | 33 | 153 | 3259 |
Eugene S. Kim | 32 | 126 | 3140 |