Institution
Catholic University of Daegu
Education•Gyeongsan-si, South Korea•
About: Catholic University of Daegu is a education organization based out in Gyeongsan-si, South Korea. It is known for research contribution in the topics: Population & Apoptosis. The organization has 2745 authors who have published 5670 publications receiving 80311 citations.
Topics: Population, Apoptosis, Cancer, Signal transduction, MAPK/ERK pathway
Papers published on a yearly basis
Papers
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TL;DR: In this article, the reduction of graphene oxide into high quality graphene nanoplatelets by simple solid-state mechanochemical ball-milling in the presence of hydrogen is reported, which shows the efficient restoration of the graphitic structure completely free from any heteroatom doping and enhanced electrical conductivities up to 120 and 3400 S/m before and after an appropriate heat treatment.
41 citations
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TL;DR: Activity-guided fractionation based on topoisomerase I inhibitory activity lead to the isolation of ten lignans from the methylene chloride extract of the bark of Machilus thunbergii SIEB, and all of these compounds exhibited weak or no cytotoxicities against either the human colon carcinoma cell line (HT-29) or the human breast carcinomacell line (MCF-7).
Abstract: Activity-guided fractionation based on topoisomerase I inhibitory activity lead to the isolation of ten lignans (1—10) from the methylene chloride extract of the bark of Machilus thunbergii SIEB. et ZUCC. (Lauraceae). These were identified as machilin A (1), erythro-austrobailignan-6 (2), meso-monomethyl dihydroguaiaretic acid (3), meso-dihydroguaiaretic acid (4), galbacin (5), machilin F (6), nectandrin A (7) nectandrin B (8), (−)-acuminatin (9) and (7S,8S)-7-(4-hydroxy-3-methoxyphenyl)-1′-formyl-3′-methoxy-8-methyldihydrobenzofuran (10) by spectral evidence. In DNA topoisomerase I and II assays in vitro at a concentration of 100 μM, 4 showed the most potent inhibitory activity, 93.6 and 82.1% inhibition, respectively, and 8 showed 79.1 and 34.3% inhibition, respectively. All of these compounds exhibited weak or no cytotoxicities against either the human colon carcinoma cell line (HT-29) or the human breast carcinoma cell line (MCF-7).
41 citations
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TL;DR: It is suggested that IL-6 produced in response to Tv infection of the prostate has an important effect on the tumor microenvironment by promoting progression of PCa cells following induction of M2 macrophage polarization.
Abstract: Trichomonas vaginalis (Tv), a protozoan parasite causing sexually-transmitted disease, has been detected in tissue of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa). IL-6, a mediator of chronic inflammation, induces the progression of prostate cancer, and influences the polarization of M2 macrophages, which are the main tumor-associated macrophages. We investigated whether IL-6 produced by human prostate epithelial cells stimulated with Tv induces the M2 polarization of THP-1-derived macrophages, which in turn promotes the progression of PCa. Conditioned medium was prepared from Tv-infected (TCM) and uninfected (CM) prostate epithelial cells (RWPE-1). Thereafter conditioned medium was prepared from macrophages after incubation with CM (M-CM) or TCM (M-TCM). RWPE-1 cells infected with Tv produced IL-6 and chemokines such as CCL2 and CXCL8. When human macrophages were treated with conditioned medium of RWPE-1 cells co-cultured with Tv (TCM), they became polarized to M2-like macrophages as indicated by the production of IL-10 and TGF-β, and the expression of CD36 and arginase-1, which are M2 macrophage markers. Moreover, proliferation of the M2-like macrophages was also increased by TCM. Blockade of IL-6 signaling with IL-6 receptor antibody and JAK inhibitor (Ruxolitinib) inhibited M2 polarization of THP-1-derived macrophages and proliferation of the macrophages. To assess the effect of crosstalk between macrophages and prostate epithelial cells inflamed by Tv infection on the growth of prostate cancer (PCa) cells, PC3, DU145 and LNCaP cells were treated with conditioned medium from THP-1-derived macrophages stimulated with TCM (M-TCM). Proliferation and migration of the PCa cells were significantly increased by the M-TCM. Our findings suggest that IL-6 produced in response to Tv infection of the prostate has an important effect on the tumor microenvironment by promoting progression of PCa cells following induction of M2 macrophage polarization.
41 citations
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TL;DR: Patients with fibromyalgia exhibit significant clinical heterogeneity, in terms of physical, social and psychological functions, as well as therapeutic responses, which may be predictive of treatment patterns.
41 citations
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TL;DR: Results show that E7 subunit vaccines act as a potent enhancer of tumor radioresponse and that this is mediated by increased sensitivity of radiated tumors to CTL-mediated killing.
41 citations
Authors
Showing all 2758 results
Name | H-index | Papers | Citations |
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Jon Zubieta | 79 | 820 | 29114 |
KiHwan Bae | 50 | 276 | 8235 |
M. A. Rao | 49 | 173 | 7792 |
Young Hag Koh | 47 | 178 | 6924 |
Heung Soo Kim | 46 | 372 | 10036 |
Maria Teresa Voso | 46 | 283 | 6815 |
Byung Sun Min | 43 | 385 | 7465 |
Hyo-Jin Kim | 40 | 394 | 6606 |
MinKyun Na | 39 | 233 | 5004 |
Young-Chae Chang | 37 | 172 | 4838 |
In-Seon Lee | 35 | 197 | 4170 |
Hyo Seon Park | 35 | 185 | 4648 |
Beom Soo Shin | 34 | 139 | 3250 |
Kwan-Kyu Park | 33 | 153 | 3259 |
Eugene S. Kim | 32 | 126 | 3140 |