Catholic University of Daegu

About: Catholic University of Daegu is a education organization based out in Gyeongsan-si, South Korea. It is known for research contribution in the topics: Population & Apoptosis. The organization has 2745 authors who have published 5670 publications receiving 80311 citations.

Bisphosphonates-related osteonecrosis of the jaw in Korea: a preliminary report

Abstract: J Korean Assoc Oral Maxillofac Surg 2013;39:9-13) Objectives: Bisphosphonates (BP) are widely used in medicine for inhibiting bone resorption; however bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a major side effect of BP To date, there have been no specific reports on the incidence of BRONJ among Koreans This study investigated the preliminary results from a nationwide survey of BRONJ in the Departments of Oral and Maxillofacial Surgery (OMFS) at individual training hospitals Materials and Methods: A total of 15 OMFS departments (10 from dental schools, 4 from medical schools, and 1 from a dental hospital) participated in a multi-centric survey This study assessed every BRONJ case diagnosed between January 2010 and December 2010 The patient age and BP type were evaluated Results: A total of 254 BRONJ cases were collected The majority of BRONJ cases were associated with oral BP therapy, while 218% of the cases were associated with intravenous administration Alendronate was the drug most frequently related to BRONJ (592% of cases), followed by risedronate (143%) and zolendronate (170%) The average age of BRONJ patients was 700±101 years, with a range of 38-88 years of age With the number of BP patients in Korea reported to be around 600,000 in 2008, the estimated incidence of BRONJ is at least 004% or 1 per 2,300 BP patients Conclusion: The results suggest that the estimated incidence of BRONJ in Korea is higher than the incidence of other countries Future prospective studies should be carried out to investigate the exact epidemiological characteristics of BRONJ in Korea

Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis.

Abstract: A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was established as 1beta,2alpha,3alpha,23-tetrahydroxyurs-12-en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. Of these, compounds 1-2 and 4-8 exhibited anti-complement activity with IC50 values of 152, 90, 130, 51, 56, 4, and 163 microM, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.