Institution
Catholic University of Daegu
Education•Gyeongsan-si, South Korea•
About: Catholic University of Daegu is a education organization based out in Gyeongsan-si, South Korea. It is known for research contribution in the topics: Population & Apoptosis. The organization has 2745 authors who have published 5670 publications receiving 80311 citations.
Topics: Population, Apoptosis, Cancer, Signal transduction, MAPK/ERK pathway
Papers published on a yearly basis
Papers
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TL;DR: A novel quantitative model is developed for these two mechanisms of aminoglycoside action, phenotypic tolerance at high bacterial densities, and adaptive bacterial resistance in response to an aminoliccoside (tobramycin) against three Pseudomonas aeruginosa strains to hold great promise to rationally design novel, synergistic aminglycoside combination dosage regimens.
Abstract: Bacterial resistance is among the most serious threats to human health globally, and many bacterial isolates have emerged that are resistant to all antibiotics in monotherapy. Aminoglycosides are often used in combination therapies against severe infections by multidrug-resistant bacteria. However, models quantifying different antibacterial effects of aminoglycosides are lacking. While the mode of aminoglycoside action on protein synthesis has often been studied, their disruptive action on the outer membrane of Gram-negative bacteria remains poorly characterized. Here, we developed a novel quantitative model for these two mechanisms of aminoglycoside action, phenotypic tolerance at high bacterial densities, and adaptive bacterial resistance in response to an aminoglycoside (tobramycin) against three Pseudomonas aeruginosa strains. At low-intermediate tobramycin concentrations (<4 mg/liter), bacterial killing due to the effect on protein synthesis was most important, whereas disruption of the outer membrane was the predominant killing mechanism at higher tobramycin concentrations (≥8 mg/liter). The extent of killing was comparable across all inocula; however, the rate of bacterial killing and growth was substantially lower at the 10(8.9) CFU/ml inoculum than that at the lower inocula. At 1 to 4 mg/liter tobramycin for strain PAO1-RH, there was a 0.5- to 6-h lag time of killing that was modeled via the time to synthesize hypothetical lethal protein(s). Disruption of the outer bacterial membrane by tobramycin may be critical to enhance the target site penetration of antibiotics used in synergistic combinations with aminoglycosides and thereby combat multidrug-resistant bacteria. The two mechanisms of aminoglycoside action and the new quantitative model hold great promise to rationally design novel, synergistic aminoglycoside combination dosage regimens.
75 citations
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Kosin University1, University of Ulsan2, Yeungnam University3, Sungkyunkwan University4, Catholic University of Korea5, Kyungpook National University6, Inha University7, Hanyang University8, Inje University9, Chonbuk National University10, Hallym University11, Seoul National University12, Catholic University of Daegu13, Yonsei University14, Chonnam National University15, Johns Hopkins University16
TL;DR: Small intestinal adenocarcinomas are diagnosed at an advanced disease stage; therefore, the development of strategies for detection at an earlier stage is needed.
75 citations
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Oklahoma Medical Research Foundation1, Wake Forest University2, University of California, Los Angeles3, Hanyang University4, University of Oklahoma5, Kyungpook National University6, Ajou University7, Dong-a University8, Yonsei University9, Catholic University of Daegu10, Chungnam National University11, Shanghai Jiao Tong University12, Tan Tock Seng Hospital13, University of Texas Southwestern Medical Center14, Seoul National University Hospital15, University of Granada16, University of California, San Francisco17, University of Southern California18, University of Alabama at Birmingham19, King's College London20, Cincinnati Children's Hospital Medical Center21
TL;DR: Using an unbiased genome‐wide association scan and replication analysis, it is sought to identify the genetic loci associated with SLE in a Korean population.
Abstract: Supported by grants from the NIH (5P01-AI-083194 to Drs. Lessard, Rasmussen, Gaffney, Alarcon-Riquelme, Criswell, Jacob, Kimberly, Vyse, Harley, Sivils, Langefeld, and Tsao; 5P01-AR-049084 to Drs. Kimberly and Langefeld; and R01-AR-043814 and R21-AR-065626 to Dr. Tsao), the Oklahoma Medical Research Foundation (to Drs. Lessard, Gaffney, and Sivils), the Alliance for Lupus Research (to Drs. Criswell and Tsao), and the Wake Forest School of Medicine Center for Public Health Genomics (to Dr. Langefeld). Dr. Criswell is recipient of a Kirkland Scholar Award. Sample collection and phenotyping of the subjects utilized in this study was funded by the Ministry for Health and Welfare, Republic of Korea (Korea Healthcare Technology R&D Project grant HI13C2124 to Dr. Bae, and HI13C1754 to Dr. Song). The out-of-study Korean control data were provided by the Korean Biobank Project, which is supported by the Korea Centers for Disease Control and Prevention at the Korea National Institute of Health.
74 citations
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TL;DR: How EMT participates to hepatic fibrosis is described and the evidence of supporting this possibility is discussed in order to reach reasonable and useful conclusions.
Abstract: Liver injuries are repaired by fibrosis and regeneration. The cause of fibrosis and diminished regeneration, especially in liver cirrhosis, is still unknown. Epithelial-mesenchymal transition (EMT) has been found to be associated with liver fibrosis. The possibility that EMT could contribute to hepatic fibrogenesis reinforced the concept that activated hepatic stellate cells are not the only key players in the hepatic fibrogenic process and that other cell types, either hepatic or bone marrow-derived cells could contribute to this process. Following an initial enthusiasm for the discovery of this novel pathway in fibrogenesis, more recent research has started to cast serious doubts upon the real relevance of this phenomenon in human fibrogenetic disorders. The debate on the authenticity of EMT or on its contribution to the fibrogenic process has become very animated. The overall result is a general confusion on the meaning and on the definition of several key aspects. The aim of this article is to describe how EMT participates to hepatic fibrosis and discuss the evidence of supporting this possibility in order to reach reasonable and useful conclusions.
74 citations
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University of Oxford1, Ajou University2, Janssen Pharmaceutica3, Erasmus University Medical Center4, Eli Lilly and Company5, University of São Paulo6, Islamic University of Gaza7, Harvard University8, King Saud University9, Georgia State University10, Belarusian State Medical University11, University of Utah12, United States Department of Veterans Affairs13, Columbia University14, Johns Hopkins University15, NewYork–Presbyterian Hospital16, National Institutes of Health17, The Catholic University of America18, University of Copenhagen19, University of Kharkiv20, National Institute for Health and Care Excellence21, Hanyang University22, Vanderbilt University Medical Center23, University of Arizona24, University of Dundee25, University of Gothenburg26, Stanford University27, Anschutz Medical Campus28, Catholic University of Daegu29, University of California, Los Angeles30, Bayer31, Shanghai University32, Tufts University33, Manchester Academic Health Science Centre34, University of Melbourne35, Peking Union Medical College36
TL;DR: Protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with CO VID-19.
Abstract: Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.
73 citations
Authors
Showing all 2758 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jon Zubieta | 79 | 820 | 29114 |
KiHwan Bae | 50 | 276 | 8235 |
M. A. Rao | 49 | 173 | 7792 |
Young Hag Koh | 47 | 178 | 6924 |
Heung Soo Kim | 46 | 372 | 10036 |
Maria Teresa Voso | 46 | 283 | 6815 |
Byung Sun Min | 43 | 385 | 7465 |
Hyo-Jin Kim | 40 | 394 | 6606 |
MinKyun Na | 39 | 233 | 5004 |
Young-Chae Chang | 37 | 172 | 4838 |
In-Seon Lee | 35 | 197 | 4170 |
Hyo Seon Park | 35 | 185 | 4648 |
Beom Soo Shin | 34 | 139 | 3250 |
Kwan-Kyu Park | 33 | 153 | 3259 |
Eugene S. Kim | 32 | 126 | 3140 |