Central University of Kerala

About: Central University of Kerala is a education organization based out in Kāsaragod, India. It is known for research contribution in the topics: Population & Catalysis. The organization has 556 authors who have published 881 publications receiving 7474 citations.

Aflatoxin-induced upregulation of protein arginine methyltransferase 5 is mediated by protein kinase C and extracellular signal-regulated kinase

Abstract: Aflatoxins are fungal metabolites classified into four major groups such as B1, B2, G1, and G2 These natural aflatoxins are designated as group I carcinogen by the International Agency for Research on Cancer Among these, the aflatoxin B1 is more potent Protein arginine methyltransferase 5, an epigenetic modulator, emerged as an oncoprotein, is overexpressed in diverse forms of cancers The present study aims to explore the AFB1-mediated overexpression of PRMT5 The AFB1 at nanomolar concentrations increased the cell viability, as well as the expression of PRMT5 and its binding partner methylosome protein 50 level significantly in L-132 and HaCaT cells The knockdown of PRMT5 by its siRNA is attenuated by AFB1, thus substantiating AFB1-mediated PRMT5 overexpression The PKC isoform-specific inhibitor study revealed direct relation with PKCα and an inverse relation with PKCδ The analysis of mitogen-activated protein kinase pathway revealed reduced p38 phosphorylation with increased phosphorylation of ERK1/2 upon exposure to AFB1 The combination of MEK and PKC inhibitors with AFB1 treatment revealed that PKCα activates downstream kinase ERK which leads to overexpression of PRMT5 In summary, we propose that PKCα and extracellular signal-regulated kinases are conjointly involved in the induction of PRMT5 upon AFB1 exposure

A study of generalized summation theorems for the series 2F1 with an applications to Laplace transforms of convolution type integrals involving Kummer's functions 1F1

Abstract: Motivated by recent generalizations of classical theorems for the series 2F1 [Integral Transform. Spec. Funct. 229(11), (2011), 823–840] and interesting Laplace transforms of Kummer’s confluent hypergeometric functions obtained by Kim et al. [Math. Comput. Modelling 55 (2012), 1068–1071], first we express generalized summations theorems in explicit forms and then by employing these, we derive various new and useful Laplace transforms of convolution type integrals by using product theorem of the Laplace transforms for a pair of Kummer’s confluent hypergeometric function.