Institution
Central University of Kerala
Education•Kāsaragod, India•
About: Central University of Kerala is a education organization based out in Kāsaragod, India. It is known for research contribution in the topics: Population & Catalysis. The organization has 556 authors who have published 881 publications receiving 7474 citations.
Topics: Population, Catalysis, Crystal structure, Gene, Magnetization
Papers
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TL;DR: Recent studies examining the clinical potential of circulating tumor cells, cell-free microRNA, exosomes, tumor DNA, and other analytes as a source of liquid biopsy biomarkers in ovarian cancer diagnosis, prognosis and response to treatment are explored.
10 citations
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TL;DR: The 4-NP-mediated upregulation of RNF2 and EZH2 resulted in epigenetic silencing of p21, which significantly increased proliferation of MCF-7 cells.
Abstract: Aim: To examine the impact of 4-nonylphenol (4-NP), on the expression of polycomb repressive complexes and cellular proliferation. Materials & methods: Cell proliferation assays, quantitative PCR, Western blotting, luciferase reporter assay, chromatin immunoprecipitation-quantitative PCR were used for the study. Results: The 4-NP at 100 nM concentration significantly increased proliferation of MCF-7 cells. It enhanced the expression of RNF2-BMI1 and EZH2-SUZ12 and concomitantly increased H2AK119ub1 and H3K27me3 repressive marks at p21 proximal promoter resulting in its reduced expression. Selective inhibition of RNF2 or EZH2 reverted the 4-NP action. The phospho-CREB, SP1 and E2F-1 are enriched at proximal promoter of RNF2 and EZH2 and cyclin D1, but not p21. Conclusion: The 4-NP-mediated upregulation of RNF2 and EZH2 resulted in epigenetic silencing of p21.
10 citations
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TL;DR: A series of Ce-containing MCM-22 zeolites with varying cerium concentrations were synthesized and were thoroughly studied by various spectroscopic and analytical methods.
10 citations
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TL;DR: In this article, laser ablated ZnFe2O4 films were deposited at O2 pressure of 0.16 mbar onto fused quartz substrates and the films about 120 nm thick are nanocrystalline and their spontaneous magnetization, 4πMs, depends on the nanograin size, which is controlled by the substrate temperature.
Abstract: Ferrimagnetic Zn-ferrite (ZnFe2O4) films can be grown with the ferromagnetic resonance linewidth of 40 Oe at 9.5 GHz without going through a high temperature processing. This presents interest for applications. The work deals with laser ablated ZnFe2O4 films deposited at O2 pressure of 0.16 mbar onto fused quartz substrates. The films about 120 nm thick are nanocrystalline and their spontaneous magnetization, 4πMs, depends on the nanograin size, which is controlled by the substrate temperature (Ts). At Ts ≈ 350 °C, where the grain distribution peaks around ∼20–30 nm, the room temperature 4πMs reaches a maximum of ∼2.3 kG. The films were studied by magnetooptical polar Kerr effect (MOKE) spectroscopy at photon energies between 1 and 5 eV. The complementary characteristics were provided by spectral ellipsometry (SE). Both the SE and MOKE spectra confirmed ferrimagnetic ordering. The structural details correspond to those observed in MgFe2O4 and Li0.5Fe2.5O4 spinels. SE experiments confirm the insulator beha...
10 citations
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Population Health Research Institute1, University of Melbourne2, Sree Chitra Thirunal Institute for Medical Sciences and Technology3, Central University of Kerala4, University of Eastern Finland5, Baker IDI Heart and Diabetes Institute6, Coventry University7, King's College London8, Monash University9, University of Kerala10
TL;DR: A community-based peer-support lifestyle intervention was cost-effective in individuals at high risk of developing diabetes in India over 2 years, and was robust to discounting and sensitivity analyses.
Abstract: Data on the cost-effectiveness of lifestyle-based diabetes prevention programs are mostly from high-income countries, which cannot be extrapolated to low- and middle-income countries. We performed a trial-based cost-effectiveness analysis of a lifestyle intervention targeted at preventing diabetes in India. The Kerala Diabetes Prevention Program was a cluster-randomized controlled trial of 1007 individuals conducted in 60 polling areas (electoral divisions) in Kerala state. Participants (30–60 years) were those with a high diabetes risk score and without diabetes on an oral glucose tolerance test. The intervention group received a 12-month peer-support lifestyle intervention involving 15 group sessions delivered in community settings by trained lay peer leaders. There were also linked community activities to sustain behavior change. The control group received a booklet on lifestyle change. Costs were estimated from the health system and societal perspectives, with 2018 as the reference year. Effectiveness was measured in terms of the number of diabetes cases prevented and quality-adjusted life years (QALYs). Three times India’s gross domestic product per capita (US$6108) was used as the cost-effectiveness threshold. The analyses were conducted with a 2-year time horizon. Costs and effects were discounted at 3% per annum. One-way and multi-way sensitivity analyses were performed. Baseline characteristics were similar in the two study groups. Over 2 years, the intervention resulted in an incremental health system cost of US$2.0 (intervention group: US$303.6; control group: US$301.6), incremental societal cost of US$6.2 (intervention group: US$367.8; control group: US$361.5), absolute risk reduction of 2.1%, and incremental QALYs of 0.04 per person. From a health system perspective, the cost per diabetes case prevented was US$95.2, and the cost per QALY gained was US$50.0. From a societal perspective, the corresponding figures were US$295.1 and US$155.0. For the number of diabetes cases prevented, the probability for the intervention to be cost-effective was 84.0% and 83.1% from the health system and societal perspectives, respectively. The corresponding figures for QALY gained were 99.1% and 97.8%. The results were robust to discounting and sensitivity analyses. A community-based peer-support lifestyle intervention was cost-effective in individuals at high risk of developing diabetes in India over 2 years. The trial was registered with Australia and New Zealand Clinical Trials Registry (
ACTRN12611000262909
). Registered 10 March 2011.
10 citations
Authors
Showing all 566 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ajay Kumar | 53 | 809 | 12181 |
Kavumpurathu Raman Thankappan | 43 | 190 | 16724 |
M.R. Prathapachandra Kurup | 31 | 157 | 2804 |
Ayyamperumal Sakthivel | 29 | 110 | 2776 |
Perumana R. Sudhakaran | 23 | 91 | 1563 |
T. Dennis Thomas | 21 | 55 | 1381 |
Pradeepan Periyat | 21 | 47 | 1875 |
Rishiram Ramanan | 21 | 29 | 2134 |
Margandan Bhagiyalakshmi | 19 | 39 | 1481 |
Maliyeckal R. Prathapachandra Kurup | 19 | 69 | 1439 |
Rajendra Pilankatta | 17 | 37 | 676 |
Subasa C. Sahoo | 15 | 53 | 622 |
V. B. Sameer Kumar | 15 | 36 | 584 |
Alagu Manickavelu | 15 | 28 | 806 |
Swapna S. Nair | 14 | 57 | 1252 |