Central University of Kerala

About: Central University of Kerala is a education organization based out in Kāsaragod, India. It is known for research contribution in the topics: Population & Catalysis. The organization has 556 authors who have published 881 publications receiving 7474 citations.

Ubiquitousness of Haloferax and Carotenoid Producing Genes in Arabian Sea Coastal Biosystems of India

Abstract: This study presents a comparative analysis of halophiles from the global open sea and coastal biosystems through shotgun metagenomes (n = 209) retrieved from public repositories. The open sea was significantly enriched with Prochlorococcus and Candidatus pelagibacter. Meanwhile, coastal biosystems were dominated by Marinobacter and Alcanivorax. Halophilic archaea Haloarcula and Haloquandratum, predominant in the coastal biosystem, were significantly (p 60% G + C content. Multidrug resistance to tetracycline, gentamicin, ampicillin, and chloramphenicol were also observed. Our study showed that coastal biosystems could be more suited for bioprospection of halophiles rather than the open sea.

An integral containing hypergeometric function

Abstract: In the theory of hypergeometric series, classical summation theorems such as those of Gauss, Gauss second, Kummer and Bailey for the series 2 F 1 play an important role. Whenever a hypergeometric series reduces to gamma function, the results are very important from the point of view of applications. Recently, several authors have used the above mentioned classical summation theorems in evaluating certain finite and infinite integrals involving hypergeometric function. The aim of this short research note is to provide an integral involving hypergeometric function. The result is derived with the help of a known and very interesting and useful integral obtained earlier by Lavoie and Trottier. Some interesting special cases have also been given.

Mesuaferrin a-bioactive flavonoid isolated from the bark of mesua ferrea l. against phospholipase a2, cyclooxygenase and lipoxygenase: an in vitro, in vivo and in silico approach

Abstract: Objective: The main objective of the present study was to evaluate the anti-inflammatory activity of isolated bioactive flavonoid Mesuaferrin-A from the bark of Mesuaferrea L. by in vitro , in vivo and in silico approach. Methods: To evaluate the effect of isolated bioactive flavonoid Mesuaferrin-A on arachidonic acid metabolizing enzymes (PLA 2 , COX-2 and 5-LOX) using in vitro methods, followed by carrageenan-induced paw edema model by in vivo and to determine the binding orientation and interactions of Mesuaferrin-A onarachidonic acid metabolizing enzymes (PLA 2 , COX-2 and 5-LOX) crystal proteins using molecular docking ( in silico ) studies. Results: Mesuaferrin-A exhibited a dose-dependent significant 5-LOX inhibitory and considerable COX-2 inhibitory activity by in vitro , The inhibitory activities of 5-LOX and COX-2 at 100µg/ml were found to be 78.67%, 81.03% with IC 50 values of 45.22µg/ml and 35.74µg/ml respectively. Whereas Mesuaferrin-A showed less PLA 2 inhibitory activity. Mesuaferrin-A showed 68.34% inhibitory activity at 400 mg/kg body weight at the late phase of carrageenan-induced paw edema, and In silico studies demonstrated that Mesuaferrin-A strongly binds with 5-LOX and COX-2, these strong binding affinity of Mesuaferrin-A on active site amino acids of 5-LOX and COX-2 may be responsible for inhibition of enzyme activity. Mesuaferrin-A showeda comparable 5-LOX and COX-2 inhibition activity with (positive control). Conclusion: It was concluded that Mesuaferrin-A act as 5-LOX and COX dual inhibitor, from the results it was suggests that Mesuaferrin-A, may be an effective preventive and therapeutic approach for patients with inflammatory-related diseases.

Chapter 9 – Metagenomics: Implications in Oral Health and Disease

Abstract: In their mouths, humans contain millions of microbes and their genes, which together constitute the oral microbiome. Oral microbes appear to be one of the important determining factors of human health. Although, most of them perform essential biological functions that impede colonization by pathogens or correlate with our physiological needs, their dysbiosis leads to oral diseases. Recent studies have disclosed that oral bacteria can trigger a progression of systemic diseases like cardiovascular disease, stroke, rheumatoid arthritis, respiratory tract infection, colorectal cancer, inflammatory bowel disease, diabetes, etc. Therefore, a thorough understanding of the oral microbiome is necessary to gain insights into probiotics and develop therapeutics to extinguish oral pathogens. Until recently, the functions of oral microbiota remained largely out of sight because microbiota assessments were based on in vitro cultivation. The practice of cultivating and isolating microorganisms remains unsatisfactory, as most of the microbial communities cannot be grown under laboratory conditions. However, the recent burgeoning field of metagenomics has transfigured the realm of classical microbiology and has succeeded in unraveling the overwhelming diversity of oral inhabitants, their tremendous genetic and metabolic repository with unprecedented speed and accuracy. This chapter provides a robust introduction to oral specific commensals and pathogens, composition of the oral microbiome, and their implications in enhancing health and developing various diseases.