Central University of Kerala

About: Central University of Kerala is a education organization based out in Kāsaragod, India. It is known for research contribution in the topics: Population & Catalysis. The organization has 556 authors who have published 881 publications receiving 7474 citations.

Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents

Abstract: The aim of this study was to evaluate whether Gemin 5, Cpeb, Xrn1, and Stau1 expression in rodent ovaries and uterine tissues is dependent on gonadotropins, steroid hormones, and leptin in the superovulation and ovariectomized mouse models of menopause. Treatment of pregnant mare serum gonadotropin-primed rats with human chorionic gonadotropin (hCG) significantly induced Stau1 and Gemin 5 messenger RNA expression in rat ovaries. Gemin 5 expression in ovaries was sustained at relatively high levels at 12 h and 24 h post hCG treatment compared to Stau1, suggesting its role in follicle development, ovulation, and luteogenesis in rat ovaries. Induced expression of Stau1 and Gemin 5 in the uterine tissue post hCG treatment at 12 h and 24 h—the duration between ovulation and post-ovulation—suggests their regulation by hCG and/or ovarian steroids, which are required for pregnancy establishment and maintenance. Cpeb expression was significantly higher (p < 0.05) in the uterine tissues after combined treatment of estradiol and leptin at 4 h. Further, the significant upregulation of uterine Gemin 5 and Xrn1 by the synergistic activities of leptin and estradiol at 40 h in ovariectomized mice establishes them as targets of cross-talk. Although these are preliminary data, the combination of Gemin 5, Cpeb, Xrn1, and Stau1 transcript alterations in rodent ovaries and uterine tissue displayed in two different experimental models underscore their importance as therapeutic targets for anovulation or in overcoming endometrial homeostasis disturbances during pregnancy due to obesity.

Active noise control for creating a quiet zone around mobile phone

Abstract: The performance of the Two Stage FxNLMS algorithm based Active Noise Control (ANC) system is evaluated in the environment of market noise. ANC is normally used for noise cancellation. While cancelling noise, ANC system cancels the noise lies in its entire frequency spectrum. However, an ANC system designed to cancel low frequency (≤500 Hz) noise, can be used in mobile phones which enables noise free communication in a noisy places such as market places, transport vehicles etc. The viability of such system in a mobile phone is examined in this paper by testing speech intelligibility in the quiet zone created by the ANC system using MOS (Mean Observation Score) method. The obtained result is satisfactory which revealed that an ANC system embedded in a mobile phone can show superior performance in a noisy environment.

Pandemics of the 21st century: lessons and future perspectives

Abstract: A pandemic is a global epidemic. Infectious diseases have killed more humans than others in history. The history of global pandemic diseases has shaped human history and has taught us how to manage current and future infectious diseases. Knowledge of past pandemics is ignored and not followed, leading to repeated failure to prevent emerging infectious diseases. Pandemics’ history has highlighted the persistent socioeconomic classes, xenophobia, and pervasive fear of the invisible enemy pathogen. Animals are the reservoir of pandemic disease pathogens; they also act as vectors. Factors such as urbanization, habitat destruction, habitat loss, and trade of high-risk live wild animals and their meat, and unsustainable food systems have been responsible for disease outbreaks. During ancient times, the best containment measures are the same weapons that are used in the 21st century to fight the new global attack. From the prehistoric to 21st-century pandemic, we have not understood many fundamental aspects of emerging infectious diseases. We need to understand the origin and evolution of the novel human emerging infectious diseases. It is critical for tracking pathogenicity, designing useful interventions, developing drug and vaccine, and innovating the technology to produce the necessary medicines and vaccines in bulk quantity rapidly.

Awareness of Stroke Warning Symptoms, Risk Factors, and Response to Acute Stroke in Biswanath District, Assam, India.

Abstract: Introduction:This study was undertaken with the following objectives: (a) to find out the awareness of warning symptoms and risk factors of stroke, (b) response to acute stroke, and (c) factors ass...