Institution
Centre for Cellular and Molecular Biology
Facility•Hyderabad, India•
About: Centre for Cellular and Molecular Biology is a facility organization based out in Hyderabad, India. It is known for research contribution in the topics: Population & Gene. The organization has 2439 authors who have published 3193 publications receiving 97833 citations.
Topics: Population, Gene, Membrane, Apoptosis, Mutant
Papers published on a yearly basis
Papers
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TL;DR: The evidence for a role for copper in pathogenic processes in Parkinson's disease is examined and reports of diverse copper-modulating strategies in in vitro and in vivo models of this disorder are considered.
Abstract: Copper is a biometal essential for normal brain development and function, thus copper deficiency or excess results in central nervous system disease. Well-characterized disorders of disrupted copper homoeostasis with neuronal degeneration include Menkes disease and Wilson's disease but a large body of evidence also implicates disrupted copper pathways in other neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis, Huntington's disease and prion diseases. In this short review we critically evaluate the data regarding changes in systemic and brain copper levels in Parkinson's disease, where alterations in brain copper are associated with regional neuronal cell death and disease pathology. We review copper regulating mechanisms in the human brain and the effects of dysfunction within these systems. We then examine the evidence for a role for copper in pathogenic processes in Parkinson's disease and consider reports of diverse copper-modulating strategies in in vitro and in vivo models of this disorder. Copper-modulating therapies are currently advancing through clinical trials for Alzheimer's and Huntington's disease and may also hold promise as disease modifying agents in Parkinson's disease.
93 citations
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TL;DR: Phenotypic, chemotaxonomic and phylogenetic analyses suggest that HHS 22(T) represents a novel species of the genus Pedobacter, for which the name Pedobacteria himalayensis sp.
Abstract: Strain HHS 22(T) was isolated from a glacial water sample from the snout of the Hamta glacier located in the Himalayan mountain ranges of India. Phenotypic, chemotaxonomic and phylogenetic analyses established the affiliation of the isolate to the genus Pedobacter. HHS 22(T) exhibits high 16S rRNA gene sequence similarity with Pedobacter cryoconitis (98 %). However, the level of DNA-DNA relatedness between HHS 22(T) and P. cryoconitis is only 42 %. Furthermore, HHS 22(T) differs from P. cryoconitis and the four other recognized species of Pedobacter in a number of phenotypic characteristics. These data suggest that HHS 22(T) represents a novel species of the genus Pedobacter, for which the name Pedobacter himalayensis sp. nov. is proposed. The type strain is HHS 22(T) (= JCM 12171(T) = MTCC 6384(T)).
93 citations
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TL;DR: Data suggest that Sd/3T represents a novel species of the genus Bacillus, and the name Bacillus indicus sp.
Abstract: Strain Sd/3T (=MTCC 4374T=DSM 15820T), an arsenic-resistant bacterium, was isolated from a sand sample obtained from an arsenic-contaminated aquifer in Chakdah district in West Bengal, India (23 degrees 3' N 88 degrees 35' E). The bacterium was Gram-positive, rod-shaped, non-motile, endospore-forming and yellowish-orange pigmented. It possessed all the characteristics that conform to the genus Bacillus, such as it had A4beta murein type (L-orn-D-Asp) peptidoglycan variant, MK-7 as the major menaquinone and iso-C15 : 0 and anteiso-C15 : 0 as the major fatty acids. Based on its chemotaxonomic and phylogenetic characteristics, strain Sd/3T was identified as a species of the genus Bacillus. It exhibited maximum similarity (95%) at the 16S rRNA gene level with Bacillus cohnii; however, DNA-DNA similarity with B. cohnii was 60.7%. Strain Sd/3T also exhibited a number of phenotypic differences from B. cohnii (DSM 6307T). These data suggest that Sd/3T represents a novel species of the genus Bacillus. The name Bacillus indicus sp. nov. is proposed.
93 citations
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TL;DR: Interestingly, it has been found that the morphology and staining pattern of the starved in vitro population of mycobacteria is similar to the persistors obtained from the lung lesions.
Abstract: Almost one-third of the world population today harbors the tubercle bacillus asymptomatically. It is postulated that the morphology and staining pattern of the long-term persistors are different from those of actively growing culture. Interestingly, it has been found that the morphology and staining pattern of the starved in vitro population of mycobacteria is similar to the persistors obtained from the lung lesions. In order to delineate the biochemical characteristics of starved mycobacteria, Mycobacteria smegmatis was grown in 0.2% glucose as a sole carbon source along with an enriched culture in 2% glucose. Accumulation of the stringent factor guanosine tetraphosphate (ppGpp) with a concomitant change in morphology was observed for M. smegmatis under carbon-deprived conditions. In addition, M. smegmatis assumed a coccoid morphology when ppGpp was ectopically produced by overexpressing Escherichia coli relA, even in an enriched medium. The Mycobacterium tuberculosis relA and spoT homologue, when induced in M. smegmatis, also resulted in the overproduction of ppGpp with a change in the bacterium's growth characteristics.
92 citations
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TL;DR: It is hypothesized that the ATP independent chaperones might offer benefit to the pathogen by promoting its existence in the latent phase of its life cycle by promoting the existence of these proteins as lower oligomers and not tetradecamers.
92 citations
Authors
Showing all 2450 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert G. Parton | 136 | 459 | 59737 |
Leonard I. Zon | 134 | 642 | 66329 |
Clive Osmond | 131 | 588 | 84694 |
Rajeev K. Varshney | 102 | 709 | 39796 |
David E. James | 96 | 394 | 30260 |
Helga Refsum | 90 | 316 | 37463 |
Ueli Grossniklaus | 88 | 306 | 26673 |
Arvind Kumar | 85 | 876 | 33484 |
Caroline H.D. Fall | 79 | 306 | 40991 |
Pramod K. Srivastava | 79 | 390 | 27330 |
Yau-Huei Wei | 78 | 385 | 22286 |
Stephen Kennedy | 75 | 300 | 17927 |
Frederic Geissmann | 73 | 147 | 37781 |
Toomas Kivisild | 72 | 203 | 22124 |
Geoffrey I. McFadden | 72 | 234 | 21772 |