Institution
Chulalongkorn University
Education•Bangkok, Thailand•
About: Chulalongkorn University is a education organization based out in Bangkok, Thailand. It is known for research contribution in the topics: Population & Catalysis. The organization has 20156 authors who have published 34324 publications receiving 647815 citations. The organization is also known as: Chula & CU.
Topics: Population, Catalysis, Medicine, Adsorption, Large Hadron Collider
Papers published on a yearly basis
Papers
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TL;DR: A method was developed by high performance liquid chromatography coupled with an electrochemical detector that could be applicable for the assay of sudan dyes in soft drink samples and obtained highly reproducible, well-defined cyclic voltammograms for sudan oxidation.
119 citations
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TL;DR: In this article, a search for the standard model Higgs boson decaying to bb when produced in association with an electroweak vector boson is reported for the following processes.
119 citations
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TL;DR: It is shown that NO impairs the apoptotic function of cells and increases their resistance to cisplatin-induced cell death in human lung carcinoma H-460 cells, indicating a novel pathway for NO regulation of Bcl-2, which provides a key mechanism for cisPlatin resistance and its potential modulation for improved cancer chemotherapy.
Abstract: Cisplatin is a potent cytotoxic agent commonly used for the treatment of solid tumors. However, tumor cell-acquired resistance to cisplatin-induced apoptosis is a major limitation for efficient therapy, as frequently observed in human lung cancer. Nitric oxide (NO) is a key regulator of apoptosis, but its role in cisplatin-induced cell death and the underlying mechanism are largely unknown. Previous studies indicate increased NO synthase activity and elevated NO production in lung carcinomas, which correlate with the incidence of chemotherapeutic resistance. Here, we show that NO impairs the apoptotic function of cells and increases their resistance to cisplatin-induced cell death in human lung carcinoma H-460 cells. The NO donors sodium nitroprusside and dipropylenetriamine NONOate were able to inhibit cisplatin-induced cell death, whereas the NO inhibitors aminoguanidine and 2-(4-carboxyphenyl)-4,4,5,5-tetra-methylimidazoline-1-oxyl-3-oxide had opposite effect. Cisplatin resistance in H-460 cells is mediated by Bcl-2, and NO up-regulates its expression by preventing the degradation of Bcl-2 via ubiquitin-proteasome pathway. Cisplatin-induced generation of reactive oxygen species causes dephosphorylation and degradation of Bcl-2. In contrast, generation of NO has no effect on Bcl-2 phosphorylation but induces S-nitrosylation of the protein, which inhibits its ubiquitination and subsequent proteasomal degradation. These findings indicate a novel pathway for NO regulation of Bcl-2, which provides a key mechanism for cisplatin resistance and its potential modulation for improved cancer chemotherapy.
119 citations
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TL;DR: In this paper, the authors reviewed the current regulatory frameworks for WCO collection and recycling practices imposed by major WCO producing countries, followed by the overview of the progress in biodiesel conversion techniques, along with novel methods to improve the feasibility for upscaling.
119 citations
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Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2294 more•Institutions (155)
TL;DR: In this article, the authors acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies: BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MOST, and NSFC (China); COLCIEN-CIAS (Colombia); DAE and DST (India); IPM (Iran); S
119 citations
Authors
Showing all 20241 results
Name | H-index | Papers | Citations |
---|---|---|---|
Paul M. Thompson | 183 | 2271 | 146736 |
P. Chang | 170 | 2154 | 151783 |
Y. B. Hsiung | 138 | 1258 | 94278 |
Shu Li | 136 | 1001 | 78390 |
Yueh-Feng Liu | 131 | 831 | 74698 |
Rong-Shyang Lu | 130 | 1252 | 82241 |
Peter Tugwell | 129 | 948 | 125480 |
Francesco Fiori | 128 | 1032 | 76699 |
Devdatta Majumder | 127 | 995 | 76105 |
Y. H. Chang | 126 | 832 | 73480 |
Henrik Zetterberg | 125 | 1736 | 72452 |
Kittikul Kovitanggoon | 123 | 684 | 62206 |
Chayanit Asawatangtrakuldee | 123 | 1086 | 71857 |
Xin Shi | 120 | 764 | 64202 |
Gurpreet Singh | 120 | 774 | 64989 |