Showing papers by "Chulalongkorn University published in 1987"
TL;DR: Data implicate myelin basic protein as an encephalitogen in these autoimmune diseases of the human nervous system, but suggest that immune responses to cerebroside and certain gangliosides may have an augmentative role in severe disease.
Abstract: Encephalitis and polyneuritis occurring after rabies vaccination are believed to be immunologically mediated. We studied antibody responses to neural antigens in 36 patients with major neurologic complications, 25 with minor complications, and 39 with no complications after immunization with a brain-derived, Semple rabies vaccine. Patients with major complications had significantly elevated levels of antibody to brain white matter as compared with the other groups (P<0.001). Assays for antibody to selected central nervous system antigens showed that high levels of serum and cerebrospinal fluid antibody to myelin basic protein correlated with the presence of major neurologic complications (both central and peripheral nervous systems). The level of antibody to cerebroside correlated best with the number of injections of vaccine, but like antibody to myelin basic protein, the antibody to cerebroside was present in the cerebrospinal fluid of patients with major complications. Some patients with major...
166 citations
TL;DR: In three of six patients with encephalomyelitis, lymphocytes showed a proliferative response to myelin, and no clinical features, including CSF content of myelin basic protein, were prognostic indicators.
Abstract: We studied 61 patients with complications of Semple-type postexposure rabies immunization. Thirty-six had neurologic signs, and 25 had only fever, headache, or myalgia. Thirty-two patients had CNS complications, and 4 had an acute peripheral neuropathy. Disease was acute and monophasic in 33, but 3 patients had progressive disease, including 1 patient with a relapsing-remitting course. No clinical features, including CSF content of myelin basic protein, were prognostic indicators. In three of six patients with encephalomyelitis, lymphocytes showed a proliferative response to myelin.
77 citations
TL;DR: Chloramphenicol-resistant S typhi, which accounted for 70% of the isolates in 1977, has since 1982 accounted for less than 2% of isolates and Salmonella paratyphl A, which was isolated from 85% and 85% of 192 Thai children with enteric fever at Children's Hospital, Bangkok, is still circulating.
Abstract: • From 1977 to 1984, Salmonella typhi was isolated from 85% and Salmonella paratyphi A was Isolated from 15% of 192 Thai children with enteric fever at children's Hospital, Bangkok. Children with enteric fever presented with sudden onset of fever and gastrointestinal symptoms. Diarrhea occurred in 62% of children with paratyphoid fever and 36% of children with typhoid fever. Rose spots were seen in 15% of patients with typhoid and 7% of patients with paratyphoid fever. There were no deaths. Bronchitis and pneumonia occurring In 11% of patients were the most common complications. Acute hemolysis occurred in 3% of the patients with typhoid fever who had thalassemia or glucose-6-phosphate dehydrogenase deficiency. Chloram-phenicol-resistant S typhi , which accounted for 70% of the isolates in 1977, has since 1982 accounted for less than 2% of isolates. ( AJDC 1987;141:862-865)
63 citations
TL;DR: In this article, six components were isolated from the fruit of Piper sarmentosum, including β-sitosterol and pellitorine, and two unsaturated pyrrolidine amides were synthesized to establish unambiguously their structures.
57 citations
TL;DR: In this paper, an increase in blood volume during acute heat stress occurred with an increase of both plasma and cell volume, and an elevation of plasma water coincided with an increased in plasma protein and glucose.
Abstract: During 5 h of acute heat exposure (41 °C), there were increases in the heart rate from 43±2 (S.E.) to 51 ± 1 beats/min, respiratory rate from 26±4 to 86± 16 breaths/min and rectal temperature from 38·5 ± 0·1 °C to 39·7 ± 0·2 °C. The flow rate of liquid from the rumen and body water turnover significantly increased while biological half life of chromium-51 ethylenediaminetetra-acetate in the rumen and tritiated water decreased from 12·9 ± 2·5 and 87·7 ± 6·8 h to 9·3 ± 2·0 and 49·2 ± 5·7 h respectively. An increase in blood volume during acute heat stress occurred with an increase of both plasma and cell volume. An elevation of plasma water coincided with an increase in plasma protein and glucose. There is evidence that the increase in plasma water during heat exposure came from extravascular tissue space and/or from the digestive tract.
43 citations
TL;DR: Six new protoberberines were found in Stephama suberosa root extracts and 10 known alkaloids were also detected.
37 citations
TL;DR: A second new sulphur-containing amide, entadamide B, has been isolated from the dry seeds of Entada phaseoloides Merr and synthesized in two steps from propiolic acid.
33 citations
TL;DR: It was found that C31 produces β-cyclodextrin as a predominant product of the degradation of starch through the action of cyclomaltodextrine glucanotransferase.
30 citations
TL;DR: Cases show that enteritis necroticans can cause substantial morbidity and mortality outside Papua New Guinea.
29 citations
TL;DR: In this paper, a skeletal group of Kopsia alkaloids, including deoxykopsijasmine and jasminiflorine, was found to form a novel skeletal group.
27 citations
TL;DR: Two-hundred-and-eighty Indonesian women provided with Norplant, a levonorgestrel-releasing implant, at various time intervals, up to 5 years after Norplant insertion, levon orgestrel and sex hormone binding globulin (SHBG) were assayed in blood plasma.
TL;DR: Three patients are reported whose cranial dura mater and bones were penetrated by intracranial glioblastomas in the absence of previous craniotomy or radiotherapy, with the gliomatous nature of the tumors confirmed by localization of cytoplasmic glial fibrillary acidic protein of the neoplastic cells.
Abstract: Three patients are reported whose cranial dura mater and bones were penetrated by intracranial glioblastomas in the absence of previous craniotomy or radiotherapy. The gliomatous nature of the tumors was confirmed by localization of cytoplasmic glial fibrillary acidic protein (GFAP) of the neoplastic cells. Review of the literature disclosed only 15 glioblastomas, including the three cases, spontaneously penetrating the cranial dura mater and bones. These patients ranged in age from 3.5 to 70 years with an average age of 40 years. The male/female ratio was 5/8. Five glioblastomas were in the temporal lobes, three were in the frontal lobes, three were in the frontotemporal regions, two were in the occipital lobes, one was in the frontoparietal region, and one was in the temporoparietooccipital region. Six glioblastomas also had spontaneous distant metastases. In the absence of previous craniotomy and radiotherapy, rapid growth of the glioblastomas may promote such spontaneous penetration into the cranial dura mater and bones.
TL;DR: The characteristic location of bilateral intense homogeneously enhanced masses with central lucencies is thought to be diagnostic of xanthogranuloma of the choroid plexus.
Abstract: Computed tomographic features of xanthogranulomas of the choroid plexus are presented The characteristic location of bilateral intense homogeneously enhanced masses with central lucencies is thought to be diagnostic of xanthogranuloma of the choroid plexus
TL;DR: It is concluded that the goal of microdose administration of 2μg levonorgestrel to the uterine cavity does not achieve the objectives of a new and improved IUD device which is safe and effective.
Journal Article•
TL;DR: A significant increment in the effective circulatory blood volume as reflected by the sustained increment in CVP, widening of PP and declining in PR as well as improvement in clinical tissue perfusion were established in 7 of these nine patients so treated.
Abstract: Nine children; 4 males and 5 females, aged ranging from 2 1/2 to 13 years presented with signs and symptoms of poor tissue perfusion associated with dengue shock syndrome. All these 9 patients were subjected to the therapeutic trial of high dose methyl prednisolone (MP; 9/9) and mannitol (M; 6/9) after their failure to the saline and plasma replacement. Following the high dose MP and M, a significant increment in the effective circulatory blood volume as reflected by the sustained increment in CVP, widening of PP and declining in PR as well as improvement in clinical tissue perfusion were established in 7 of these nine patients so treated.
TL;DR: Review of the clinical features of this fatal complication in drug abusers and narcotic addicts disclosed that hemiparesis and facial weakness are common and brain or CT scan along with brain biopsy are necessary for rapid diagnosis and prompt treatment.
TL;DR: Parthenolide was reported previously to possess anti-tumor activity, and in the present study it is reported on the significant activity of the new alkaloid 3 in the KB cell culture assay.
Abstract: Paramichelia baillonii has been used by the natives of Northern Thailand for medicinal purposes. Four components have been isolated from the bark of this plant and their structures determined by spectroscopic means. Three of the components had been reported previously: the germacranolide epoxides (--)-dihydroparthenolide [1] and (--)-parthenolide [2] and the oxoaporphinoid alkaloid liriodenine [4]. The fourth component is an unusual new germacranolide alkaloid which has been named (--)-bisparthenolidine [3] because it was presumably formed in the plant from ammonia and two molecules of parthenolide. Parthenolide was reported previously to possess anti-tumor activity, and in the present study we report on the significant activity of the new alkaloid 3 in the KB cell culture assay.
TL;DR: A parapharyngeal ectomesenchymoma consisting of mixed malignant fibrous histiocytoma and primitive neuroectodermal tumour with neuroglial differentiation occurred in a 36-year-old woman.
Abstract: A parapharyngeal ectomesenchymoma consisting of mixed malignant fibrous histiocytoma and primitive neuroectodermal tumour with neuroglial differentiation occurred in a 36-year-old woman. Immunohistochemical and electron microscopic studies verified the combined mesenchymal and neuroectodermal components within the tumour. Only 9 similar cases, including the present one, are on record. The patients ranged in age from 6 months to 49 years, with an average age of 18 years. The male: female ratio was 4:5. The tumour location was widespread. All reported ectomesenchymomas were histopathologically malignant. Recurrence and/or metastasis was/were common. The neural crest has been suggested as the origin of the ectomesenchymomas.
TL;DR: Six edible Thai mushroom species were analysed for protein, in vitro protein digestibility, amino acids and major and trace elements and the contents of mineral elements showed great variation.
Abstract: Six edible Thai mushroom species were analysed for protein, in vitro protein digestibility, amino acids and major and trace elements. The results for protein and amino acids were discussed relative to the contents in Thai rice. The contents of mineral elements showed great variation, in agreement with literature data. Two samples (Hunukao and Hom) were rich in calcium and one (Phang) was rich in iron and copper. For comparison results for samples of edible mushrooms obtained in Norway were included.
TL;DR: It is concluded that at least two (and probably more) genetically distinct clones of parasites with increased tolerance to mefloquine were present in the parasite population before me floquine treatment was given, and were selected under meFLoquine pressure.
TL;DR: There was almost a 10-fold rise in the total IgE in the serum of patients with proven gnathostomiasis and in those with intermittent cutaneous migratory swellings, indicating that G. spinigerum infection potentiates IgE production similarly to many other nematode parasites.
Abstract: Specific IgE antibody levels in the serum of patients with proven gnathostomiasis and in those with intermittent cutaneous migratory swellings were determined by the enzyme-linked immunosorbent assay (ELISA) using aqueous extracts of Gnathostoma spinigerum infective larvae as antigen. There was not only an elevation of specific IgE antibody levels but also a marked increase of total IgE in the serum of these patients. The mean levels of specific IgE antibody in both groups of patients were significantly higher than that of healthy controls (P<0·01). Only one of the 50 serum specimens tested had an ELISA reading that fell within the mean + 2 standard deviations of the control group, suggesting that the method would be useful with a high degree of reliability in confirming a clinical diagnosis of gnathostomiasis in humans. Compared with healthy controls, there was almost a 10-fold rise (P<0·01) in the total IgE in the serum of these patients, indicating that G. spinigerum infection potentiates IgE production similarly to many other nematode parasites.
TL;DR: The results showed no significant difference in growth of the four types of culture methods at the two locations, but after 8 months the mussel production in the onion bags was higher than that on the rope substrate, and the longline method seemed preferable because it was stronger, lasted longer and allowed easy maintenance.
TL;DR: A urologic study of 28 patients revealed that 23 patients (83%) had organic disease, 20 of whom had lower urinary tract abnormalities, and patients who were re-evaluated had no recurrent urinary frequency symptoms after five years of follow-up.
TL;DR: A coagglutination test for detection of group A streptococci in throat samples was evaluated in a multicentre study and found to be about 95 % sensitive when applied to swabs taken from symptomatic patients which yielded more than 100 colonies per plate on culture.
Abstract: A coagglutination test for detection of group A streptococci in throat samples was evaluated in a multicentre study and found to be about 95 % sensitive when applied to swabs taken from symptomatic patients which yielded more than 100 colonies per plate on culture. The sensitivity of the test dropped significantly when it was applied to swabs giving fewer than 100 colonies on culture. The specificity of the test was high regardless of colony count on conventional media.
TL;DR: Water samples collected from the Chao Phraya, Bang Pakong and Tha-Chin rivers and the Upper Gulf of Thailand in the rainy season and dry season in 1983 and 1984 suggest a multiplicity of sources ranging from indigenous biological materials to petroleum activities.
TL;DR: In this paper, the influence of small monovalent cations on neighbouring hydrogen bonds is studied for imidazole-water adducts by means of ab initio calculations using minimal Gaussian basis sets.
TL;DR: The results obtained in this study suggest that conventional electrophoresis is not enough to characterize a new variant and to discriminate it from previously reported variants and that PAGIF could clearly discriminate the two variants that had a similar mobility on AGE.
Abstract: The genetic polymorphism of factor B (BF) in four Asian populations was studied by immunofixation after agarose gel electrophoresis (AGE) in both veronal buffer (VB) and Tris/glycine/veronal buffer (TGVB). A suballele of the BF*F and three rare alleles were detected in a Chinese population. The subtype and the rare variants were further characterized by using isoelectric focusing in polyacrylamide gels (PAGIF) and by zymosan treatment of the serum samples. The subtype was identified as BFFb1, first defined in the Japanese and found to occur at a polymorphic frequency. One of the rare variants exhibited an intermediate mobility between BFF and BFS and seemed to be similar to BFF025. PAGIF, however, could clearly discriminate the two variants that had a similar mobility on AGE. The results obtained in this study suggest that conventional electrophoresis is not enough to characterize a new variant and to discriminate it from previously reported variants. The findings obtained on immunofixation after AGE/TGVB and in PAGIF must be added to those obtained by the standard method.