Institution
Coeliac UK
Nonprofit•High Wycombe, United Kingdom•
About: Coeliac UK is a nonprofit organization based out in High Wycombe, United Kingdom. It is known for research contribution in the topics: Population & Coeliac disease. The organization has 11 authors who have published 21 publications receiving 1174 citations. The organization is also known as: The Coeliac Society.
Topics: Population, Coeliac disease, Gluten free, Gluten, Medical prescription
Papers
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Karolinska Institutet1, Örebro University2, Universidad del Salvador3, University of Nottingham4, University of Salerno5, Guy's and St Thomas' NHS Foundation Trust6, Columbia University7, British Dietetic Association8, Queen Mary University of London9, Harvard University10, St Mary's Hospital11, University of Oslo12, Coeliac UK13, Cardiff and Vale University Health Board14, University of Newcastle15, University of Sheffield16
TL;DR: A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries reviewed the literature on diagnosis and management of adult coeliac disease and the recommendations are presented.
Abstract: A multidisciplinary panel of 18 physicians and 3 nonphysicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterology. Areas of controversies were explored through phone meetings and web surveys. Nine working groups examined the following areas of CD diagnosis and management: classification of CD; genetics and immunology; diagnostics; serology and endoscopy; follow-up; gluten-free diet; refractory CD and malignancies; quality of life; novel treatments; patient support; and screening for CD.
842 citations
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TL;DR: The revised BSPGHAN guidelines represent an important shift in diagnostic strategy, aimed at simplifying and shortening the diagnostic process in selected cases, and should be of assistance for paediatricians in specialties other than gastroenterology.
Abstract: The revised BSPGHAN guidelines for the diagnosis and management of coeliac disease represent an important shift in diagnostic strategy, aimed at simplifying and shortening the diagnostic process in selected cases. Guidance is given concerning the indications for testing for coeliac disease, which is still significantly underdiagnosed in the UK. While screening data suggest a likely incidence of 1 in 100 persons, only 10%-20% of this figure is currently being diagnosed.The BSPGHAN guidelines follow the new ESPGHAN guidelines in overall diagnostic strategy, while providing more didactic stratagems, which should be of assistance for paediatricians in specialties other than gastroenterology.
168 citations
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TL;DR: Patients with CD should avoid gluten and maintain a balanced diet to ensure an adequate intake of nutrients, vitamins, fibre and calcium and the vitamins and mineral content of a GFD.
Abstract: Background: A gluten-free diet (GFD) is currently the only available therapy for coeliac disease (CD). Objectives: We aim to review the literature on the GFD, the gluten content in naturally gluten-free (GF) and commercially available GF food, standards and legislation concerning the gluten content of foods, and the vitamins and mineral content of a GFD. Methods: We carried out a PubMed search for the following terms: Gluten, GFD and food, education, vitamins, minerals, calcium, Codex wheat starch and oats. Relevant papers were reviewed and for each topic a consensus among the authors was obtained. Conclusion: Patients with CD should avoid gluten and maintain a balanced diet to ensure an adequate intake of nutrients, vitamins, fibre and calcium. A GFD improves symptoms in most patients with CD. The practicalities of this however, are difficult, as (i) many processed foods are contaminated with gluten, (ii) staple GF foods are not widely available, and (iii) the GF substitutes are often expensive. Furthermore, (iv) the restrictions of the diet may adversely affect social interactions and quality of life. The inclusion of oats and wheat starch in the diet remains controversial.
93 citations
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TL;DR: Careful evaluation and reporting of outcome measures will increase transparency and comparability of coeliac disease therapeutic trials, and will benefit patients, healthcare and the pharmaceutical industry.
Abstract: Objective A gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies We aimed to review the literature on coeliac disease therapeutic trials and issue recommendations for outcome measures Design Based on a literature review of 10 062 references, we (17 researchers and 2 patient representatives from 10 countries) reviewed the use and suitability of both clinical and non-clinical outcome measures We then made expert-based recommendations for use of these outcomes in coeliac disease trials and identified areas where research is needed Results We comment on the use of histology, serology, clinical outcome assessment (including patient-reported outcomes), quality of life and immunological tools including gluten immunogenic peptides for trials in coeliac disease Conclusion Careful evaluation and reporting of outcome measures will increase transparency and comparability of coeliac disease therapeutic trials, and will benefit patients, healthcare and the pharmaceutical industry
82 citations
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01 Nov 2005TL;DR: Current advice is that dietary adherence is necessary to avoid the long-term complications, which are, principally, osteoporosis and small bowel lymphoma, but risk of these complications diminishes very considerably in patients who are on a gluten-free diet.
Abstract: Coeliac disease is a lifelong intolerance to the gluten found in wheat, barley and rye, and some patients are also sensitive to oats. The disease is genetically determined, with 10% of the first-degree relatives affected and 75 % of monozygotic twins being concordant. Of the patients with coeliac disease 95% are human leucocyte antigen (HLA)-DQ2 or HLA-DQ8 positive. Characteristically, the jejunal mucosa becomes damaged by a T-cell-mediated autoimmune response that is thought to be initiated by a 33-mer peptide fragment in A2 gliadin, and patients with this disorder have raised levels of anti-endomysium and tissue transglutaminase antibodies in their blood. Coeliac disease is the major diagnosable food intolerance and, with the advent of a simple blood test for case finding, prevalence rates are thought to be approximately 1:100. Classically, the condition presented with malabsorption and failure to thrive in infancy, but this picture has now been overtaken by the much more common presentation in adults, usually with non-specific symptoms such as tiredness and anaemia, disturbance in bowel habit or following low-impact bone fractures. Small intestinal biopsy is necessary for diagnosis and shows a characteristically flat appearance with crypt hypoplasia and infiltration of the epithelium with lymphocytes. Diet is the key to management and a gluten-free diet effectively cures the condition. However, this commitment is lifelong and many aisles in the supermarket are effectively closed to individuals with coeliac disease. Compliance can be monitored by measuring antibodies in blood, which revert to negative after 6-9 months. Patients with minor symptoms, who are found incidentally to have coeliac disease, often ask whether it is necessary to adhere to the diet. Current advice is that dietary adherence is necessary to avoid the long-term complications, which are, principally, osteoporosis and small bowel lymphoma. However, risk of these complications diminishes very considerably in patients who are on a gluten-free diet.
77 citations
Authors
Showing all 11 results
Name | H-index | Papers | Citations |
---|---|---|---|
Norma McGough | 5 | 9 | 891 |
Heidi Urwin | 4 | 6 | 40 |
Sarah Sleet | 3 | 8 | 247 |
N. Mendoza | 1 | 1 | 12 |
N. Mendoza | 1 | 1 | 33 |
Mike Davidson | 1 | 1 | 719 |
Emma Merrikin | 1 | 1 | 1 |
Emily Kirk | 1 | 1 | 1 |
N. McGough | 1 | 1 | 33 |
Geraint Preest | 1 | 1 | 1 |
Kathryn Miller | 1 | 1 | 8 |