Joint BSPGHAN and Coeliac UK guidelines for the diagnosis and management of coeliac disease in children
Simon Murch,H. R. Jenkins,Marcus Auth,Ronald Bremner,Assad Butt,Mark Furman,Peter M. Gillett,Fevronia Kiparissi,Maureen Lawson,Bruce McLain,Mary-Anne C. Morris,Sarah Sleet,Matthew Thorpe +12 more
TLDR
The revised BSPGHAN guidelines represent an important shift in diagnostic strategy, aimed at simplifying and shortening the diagnostic process in selected cases, and should be of assistance for paediatricians in specialties other than gastroenterology.Abstract:
The revised BSPGHAN guidelines for the diagnosis and management of coeliac disease represent an important shift in diagnostic strategy, aimed at simplifying and shortening the diagnostic process in selected cases. Guidance is given concerning the indications for testing for coeliac disease, which is still significantly underdiagnosed in the UK. While screening data suggest a likely incidence of 1 in 100 persons, only 10%-20% of this figure is currently being diagnosed.The BSPGHAN guidelines follow the new ESPGHAN guidelines in overall diagnostic strategy, while providing more didactic stratagems, which should be of assistance for paediatricians in specialties other than gastroenterology.read more
Citations
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ISPAD Clinical Practice Consensus Guidelines 2018: Nutritional management in children and adolescents with diabetes.
Carmel E. Smart,Carmel E. Smart,Francesca Annan,Laurie A. Higgins,Elisabeth Jelleryd,Mercedes Lopez,Carlo L. Acerini +6 more
TL;DR: Although there is strong evidence for nutritional requirements in young people the scientific evidence base for many aspects of diabetes dietary management is still emerging and it is important to individualize nutrition interventions and meal plans.
Journal ArticleDOI
Genomic risk prediction of complex human disease and its clinical application
Gad Abraham,Michael Inouye +1 more
TL;DR: Recent findings and approaches to genomic prediction model construction and performance are reviewed, then the potential benefits of such models in two complex human diseases, aiding diagnosis in celiac disease and prospective risk prediction for cardiovascular disease are contrasted.
Journal ArticleDOI
ISPAD Clinical Practice Consensus Guidelines 2014. Nutritional management in children and adolescents with diabetes.
Carmel E. Smart,Francesca Annan,Luciana P C Bruno,Laurie A. Higgins,Carlo L. Acerini,Adolescent Diabetes +5 more
TL;DR: This research presents a probabilistic analysis of the immune system’s role in the development of obesity and its role in disease progression in children and young adults.
Journal ArticleDOI
Risk of pediatric celiac disease according to HLA haplotype and country
TL;DR: There was statistically significant higher risk of celiac disease autoimmunity and Celiac disease in infants from Europe (highest risk in Sweden), female gender, and those with family history of celiasis disease.
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ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes.
Farid H. Mahmud,Nancy Samir Elbarbary,Elke Fröhlich-Reiterer,Reinhard W. Holl,Olga Kordonouri,Mikael Knip,Kimber M. Simmons,Maria E. Craig,Maria E. Craig,Maria E. Craig +9 more
TL;DR: Monitoring of anthropometric measurements and physical development, using age- appropriate standards and taking mid-parental height into account, is a crucial element in the care of children and adolescents with diabetes.
References
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Journal ArticleDOI
The histopathology of coeliac disease: time for a standardized report scheme for pathologists.
TL;DR: The most important histological differential diagnoses are given, as well as a definition of the different clinical forms of coeliac disease such as symptomatic, silent, latent, potential, treated and refractory coeliasis.
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The Oslo definitions for coeliac disease and related terms
Jonas F. Ludvigsson,Daniel A. Leffler,Julio C. Bai,Federico Biagi,Alessio Fasano,Peter H.R. Green,Marios Hadjivassiliou,Katri Kaukinen,Ciaran P. Kelly,Jonathan N. Leonard,Knut E.A. Lundin,Joseph A. Murray,David S Sanders,David S Sanders,Marjorie M. Walker,Fabiana Zingone,Carolina Ciacci +16 more
TL;DR: A multidisciplinary task force of 16 physicians from seven countries used the electronic database PubMed to review the literature for CD-related terms and suggested a definition for each term, followed by feedback through a web survey on definitions and discussions during a meeting in Oslo.
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Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
Ivor D. Hill,Martha H. Dirks,Gregory S. Liptak,Richard B. Colletti,Alessio Fasano,Stefano Guandalini,Edward J. Hoffenberg,Karoly Horvath,Joseph A. Murray,Mitchell Pivor,Ernest G. Seidman +10 more
TL;DR: It is recommended that children and adolescents with symptoms of celiac disease or an increased risk for Celiac disease have a blood test for antibody to tissue transglutaminase (TTG), and that those with an elevated TTG be referred to a pediatric gastroenterologist for an intestinal biopsy and treated with a strict gluten-free diet.
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Integration of genetic and immunological insights into a model of celiac disease pathogenesis.
TL;DR: Comparison of genetic pathways as well as genetic susceptibility loci between CD and other autoimmune and inflammatory disorders reveals that CD bears stronger resemblance to T cell-mediated organ-specific autoimmune than to inflammatory diseases.