European Business School London

About: European Business School London is a based out in . It is known for research contribution in the topics: Real estate investment trust & Empirical research. The organization has 323 authors who have published 636 publications receiving 17446 citations. The organization is also known as: EBS London.

Combination therapies or standalone interventions? innovation options for pharmaceutical firms fighting cancer

Abstract: Innovation is key to the pharma model, from an initial discovery to the final development of a marketable drug. Here, we explore the innovation options in the fiercely contested therapeutic area of Oncology. We studied clinical development of drugs targeting PD-1 and PD-L1 pathway. In this interesting contest, companies seem to be focusing on standalone interventions (exploratory innovation) and combination therapy (exploitative innovation) in clinical development. Merck Sharp and Dohme, having a relatively weaker oncology pipeline seems to take exploratory approach of standalone intervention. However for some indications, MSD seems to harness exploitative innovation approach through combination therapies by collaborating with external partners. AstraZeneca in contrast seems to focus on exploitative approach using its strong oncology pipeline for combination therapies. Our work provides a framework to understand exploratory (standalone) and exploitative (combination therapy) innovation approaches and thei...

Anforderungen an Unternehmensgründer in der Net Economy

Abstract: Fur den Erfolg eines Unternehmen spielt es zum einen eine Rolle, wie vorteilhaft und innovativ die angebotenen Produkte sind, wie ausgereift das Unternehmenskonzept ist und wie die auseren Bedingungen aussehen. Genau so wichtig sind jedoch auch die Fahigkeiten und Fertigkeiten des Unternehmensgrunders. Denn der Grunder ist es, der erkennen muss, dass eine Marktlucke tur ein spezielles Produkt existiert, wie dieses Produkt zu vermarkten ist, wie er das Unternehmen organisiert und strukturiert. Er ist es, der mit Finanzgebern, Kunden, Lieferanten und Mitarbeitern umgehen, sie von seiner Idee uberzeugen muss. Er ist es, der auch in schwierigen Situationen an seinem Ziel weiterarbeiten muss. Im Gegensatz zum angestellten Manager im Groskonzern, oder noch starker dem Spezialisten auf der Stabstelle im Groskonzern, ist der Unternehmensgrunder wenigen externen Vorgaben unterworfen. Er hat kein von ausen gesetztes Unternehmensziel, keine vorgeschriebene Unternehmenskultur, insbesondere aber keine Vorgesetzten, die ihm sagen, was er tun soll. Die Situation einer Unternehmensgrundung bietet so viele Freiheitsgrade, dass die Umwelt hier nur einen geringen Einfluss auf das Verhalten des Einzelnen hat. Zudem wahlt der Grunder ja in gewissem Umfang seine Umwelt selbst aus, indem er sich eine bestimmte Branche, ein bestimmtes Geschaftsfeld etc. aussucht. Gerade im Bereich der Net Economy gibt es innovative Geschaftsmodelle, die noch nicht rechtlich geregelt sind und wo es wenig gesellschaftliche Konventionen gibt, die den Einzelnen ein bestimmtes Verhalten vorgeben.

Politics and AIS: Where Do We Draw the Line?

Abstract: The Association for Information Systems (AIS) is the preeminent global professional association for academics in the Information Systems (IS) discipline. Throughout its more than 20-year history, AIS governance documents have included no guidance on matters related to national or international politics. However, recent events have challenged AIS to reconsider its responsibility as a political or moral advocate for its members and the discipline it serves. A panel at ECIS 2017 explored the ways in which AIS has inadvertently or intentionally entered the political fray and debated the benefits and drawbacks of taking on a more formal political position. This paper presents the positions that each panelist raised and summarizes the active discussion that followed. It concludes with a set of questions that constitute a “call to action” to the AIS council to enact a politically acceptable set of core values to benefit its members.

Entrepreneurial Orientation in the Context of Social Venture Creation

Abstract: This qualitative field study examines how the different elements of entrepreneurial orientation contribute to the creation of a social venture in a large international nonprofit organization. Social ventures have gained importance in the third sector, due to public budget cuts and the subsequent “marketization” of charitable organizations. So far, entrepreneurial activities of third sector organizations have mainly been studied on the individual level, focusing on the individual social entrepreneur and his start-up. We apply the organization-level construct of entrepreneurial orientation, usually found in corporate entrepreneurship literature, to explore the role of entrepreneurial elements in the pre-start up phase of venture creation of a large nonprofit organization. Drawing on the narrative analysis of interviews and archival data, we describe how a venture is formatted along the elements of entrepreneurial orientation: proactive behavior, innovativeness, out-sourcing risk and collaboration. However, ...

How Do Trading Costs Vary Across the Day? A Note on the Innovative XLM Measure for Small Caps at the Frankfurt Stock Exchange

Abstract: This article provides empirical evidence on the intraday pattern of trading costs for German small-cap stocks in the electronic trading system Xetra at the Frankfurt Stock Exchange. Theoretical papers draw ambiguous conclusions as to whether trading costs should increase or decrease with concentrated liquidity, and only very limited empirical evidence is available on intraday execution costs for stock trading in Germany. The authors investigate the XLM variable, which is a more comprehensive measure of trading costs than conventional indicators, such as the bid–ask spread or trading volume. The empirical evidence for the TecDAX stocks under investigation suggests a reverse J-shaped intraday profile for execution costs. Thus, trading is most expensive in the first 30 minutes after Xetra opens, and it is cheapest at the time when the NYSE starts trading. The authors conclude that cross-border integration of stock exchanges fosters market quality. TOPICS:Volatility measures, equity portfolio management, exchanges/markets/clearinghouses