Hebron University

About: Hebron University is a education organization based out in Hebron, Palestinian Territory. It is known for research contribution in the topics: Population & Cancer. The organization has 2714 authors who have published 4180 publications receiving 163736 citations.

Phytohormones in Botrytis-plant interactions.

Abstract: Several lines of evidence suggest that plant hormones are involved in mediating Botrytis interaction with plants. External treatments with some plant hormones such as auxins and gibberellins can suppress disease development, while ethylene and abscisic acid seem to enhance the disease. Increased ethylene levels by Botrytis infection are well documented. Not only the plant, but also the fungus is capable of producing different hormones and fungal development may be influenced by these hormones. Little direct evidence is available on the involvement of plant hormones in vegetative and pathogenic Botrytis development. Most of the data come from studies on the production of ethylene in infected plants, on its possible effect on the disease and on ethylene production by Botrytis. Production of other plant hormones by Botrytis and their possible role in disease and fungal development have hardly been studied. The production of various plant hormones in Botrytis, and the effect that they may have on disease and fungal development are reported.

Radioactivity concentration in soil samples in the southern part of the West Bank, Palestine.

Abstract: The activity concentrations of naturally occurring radioactive materials such as (238)U, (232)Th and (40)K were measured for 38 soil samples collected from diverse zones in the southern area of West Bank, Palestine using gamma-ray spectroscopy. The measured activities of (238)U, (232)Th and (40)K were found to range from 32.9 to 104.7, 14.5 to 76.6 and 297 to 962 Bq kg(-1) with averages value of 68.7, 48.0 and 630 Bq kg(-1), respectively. The obtained values of activity concentrations are higher than the world average of 35, 30 and 500 Bq kg(-1) for (238)U, (232)Th and (40)K, respectively. The measured (137)Cs activity concentration was found to range from 1.8 to 36.1 Bq kg(-1) with an average value of 8.5 Bq kg(-1). The detected activities were attributed to the fallout of (137)Cs, which is the only man-made radionuclide. The calculated average of the total gamma-radiation dose rate of natural radionuclides, (137)Cs and cosmic radiation is 121.4 nGy h(-1). The radium equivalent activity (R(aeq)), dose rate (D(r)), external hazard index (H(ex)) and radioactivity level index (I(gamma)) in all samples are presented. Some values were found to be in the range of worldwide values, whereas others were above the worldwide values.

Clinical activity and safety of PF-06463922 from a dose escalation study in patients with advanced ALK+ or ROS1+ NSCLC.

Abstract: 8018 Background: Anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) fusions define 2 molecular subsets of patients (pts) with non-small cell lung cancer (NSCLC). PF-06463922 is a selectiv...

Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from the EUROAPS registry

Abstract: OBJECTIVES To compare clinical features, laboratory data and fetal-maternal outcomes between 1000 women with obstetric APS (OAPS) and 640 with aPL-related obstetric complications not fulfilling Sydney criteria (non-criteria OAPS, NC-OAPS). METHODS This was a retrospective and prospective multicentre study from the European Registry on Obstetric Antiphospholipid Syndrome. RESULTS A total of 1650 women with 5251 episodes, 3601 of which were historical and 1650 latest episodes, were included. Altogether, 1000 cases (OAPS group) fulfilled the Sydney classification criteria and 650 (NC-OAPS group) did not. Ten NC-OAPS cases were excluded for presenting thrombosis during follow-up. All cases were classified as category I (triple positivity or double positivity for aPL) or category II (simple positivity). Overall, aPL laboratory categories showed significant differences: 29.20% in OAPS vs 17.96% in NC-OAPS (P < 0.0001) for category I, and 70.8% in OAPS vs 82% in NC-OAPS (P < 0.0001) for category II. Significant differences were observed when current obstetric complications were compared (P < 0.001). However, major differences between groups were not observed in treatment rates, livebirths and thrombotic complications. In the NC-OAPS group, 176/640 (27.5%) did not fulfil Sydney clinical criteria (subgroup A), 175/640 (27.34%) had a low titre and/or non-persistent aPL positivity but did meet the clinical criteria (subgroup B) and 289/640 (45.15%) had a high aPL titre but did not fulfil Sydney clinical criteria (subgroup C). CONCLUSION Significant clinical and laboratory differences were found between groups. Fetal-maternal outcomes were similar in both groups when treated. These results suggest that we could improve our clinical practice with better understanding of NC-OAPS patients.