Jiangxi University of Science and Technology

About: Jiangxi University of Science and Technology is a education organization based out in Ganzhou, China. It is known for research contribution in the topics: Microstructure & Alloy. The organization has 6958 authors who have published 5576 publications receiving 50650 citations.

β-Cyclodextrin modified Pt(II) metallacycle-based supramolecular hyperbranched polymer assemblies for DOX delivery to liver cancer cells.

Abstract: Despite the widespread clinical application of chemotherapeutic anticancer drugs, their adverse side effects and inefficient performances remain ongoing issues. A drug delivery system (DDS) designed for a specific cancer may therefore overcome the drawbacks of single chemotherapeutic drugs and provide precise and synergistical cancer treatment by introducing exclusive stimulus responsiveness and combined chemotherapy properties. Herein, we report the design and synthesis of a supramolecular drug delivery assembly 1 constructed by orthogonal self-assembly technique in aqueous media specifically for application in liver cancer therapy. Complex 1 incorporates the β-cyclodextrin host molecule-functionalized organoplatinum(II) metallacycle 2 with two specific stimulus-responsive motifs to the signaling molecule nitric oxide (NO), in addition to the three-armed polyethylene glycol (PEG) functionalized ferrocene 3 with redox responsiveness. With this molecular design, the particularly low critical aggregation concentration (CAC) of assembly 1 allowed encapsulation of the commercial anticancer drug doxorubicin (DOX). Controlled drug release was also achieved by morphological transfer via a sensitive response to the endogenous redox and NO stimuli, which are specifically related to the microenvironment of liver tumor cells. Upon combination of these properties with the anticancer ability from the platinum acceptor, in vitro studies demonstrated that DOX-loaded 1 is able to codeliver anticancer drugs and exhibit therapeutic effectiveness to liver tumor sites via a synergistic effect, thereby revealing a potential DDS platform for precise liver cancer therapeutics.

A step-by-step multiple stimuli-responsive metal-phenolic network prodrug nanoparticles for chemotherapy

Abstract: Currently, chemotherapy is the main clinical therapy of tumors. Depressingly, most chemotherapeutic drugs such as doxorubicin and paclitaxel (PTX) have poor water solubility, leading to low bioavailability and serious side effects. Till now, although a variety of nanoparticulate drug delivery systems have been designed to ameliorate the above disadvantage of chemotherapy drugs, their application is still severely limited due to the complex preparation, poor stability, low drug loading, and premature drug release. Herein, a metal phenolic network-based drug delivery system with superior stability, satisfactory drug loading capacity, good biocompatibility, reduced undesired premature release, and excellent anti-tumor ability has been established for achieving step-by-step multiple stimuli-responsive drug delivery. Firstly, the redox-responsive dimeric paclitaxel (diPTX) prodrug was synthesized. Then diPTX@Fe&tannic acid (diPTX@Fe&TA) complex nanoparticles with satisfactory PTX loading capacity were obtained by deposition of Fe&TA network complex on the nanocore of diPTX rapidly with a simple method. The diPTX@Fe&TA nanoparticles have a hydrodynamic diameter of 152.6 ± 1.2 nm, long-term colloidal stability, and high PTX loading content of 24.7%. Besides, diPTX@Fe&TA could expose to the acidic lysosomal environment and the reduction cytoplasmic environment continuously, resulting in the sequential release of diPTX and PTX when it was phagocytosed by tumor cells. Meanwhile, PTX showed almost no release under physiological condition (pH 7.4), which effectively inhibited the undesirable premature release of PTX. More importantly, diPTX@Fe&TA could suppress the growth of tumor effectively in vivo, along with negligible toxicity for organs. This work developed a simple and novel approach for the construction of a stepwise multiple stimuli-responsive drug delivery system with superior stability and satisfactory drug loading capacity to inhibit tumor growth effectively.

Thermodynamic analysis of the carbothermic reduction of a high-phosphorus oolitic iron ore by FactSage

Abstract: A thermodynamic analysis of the carbothermic reduction of high-phosphorus oolitic iron ore (HPOIO) was conducted by the FactSage thermochemical software. The effects of temperature, C/O ratio, additive types, and dosages both on the reduction of fluorapatite and the formation of liquid slag were studied. The results show that the minimum thermodynamic reduction temperature of fluorapatite by carbon decreases to about 850°C, which is mainly ascribed to the presence of SiO2, Al2O3, and Fe. The reduction rate of fluorapatite increases and the amount of liquid slag decreases with the rise of C/O ratio. The reduction of fluorapatite is hindered by the addition of CaO and Na2CO3, thereby allowing the selective reduction of iron oxides upon controlled C/O ratio. The thermodynamic results obtain in the present work are in good agreement with the experimental results available in the literatures.