Institution
Kikkoman
Company•Noda, Japan•
About: Kikkoman is a company organization based out in Noda, Japan. It is known for research contribution in the topics: Luciferase & Gene. The organization has 662 authors who have published 802 publications receiving 19532 citations. The organization is also known as: KIKKOMAN CORPORATION & Kikkōman Kabushiki-gaisha.
Topics: Luciferase, Gene, Fermentation, Peptide sequence, Aspergillus oryzae
Papers published on a yearly basis
Papers
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National Institute of Advanced Industrial Science and Technology1, National Institute of Technology and Evaluation2, Intec, Inc.3, Tohoku University4, University of Tokyo5, Nagoya University6, Tokyo University of Agriculture and Technology7, University of Manchester8, Broad Institute9, George Washington University10, Agricultural Research Service11, University of Nottingham12, Tulane University13, J. Craig Venter Institute14, Kikkoman15, Kyushu University16, Nara Institute of Science and Technology17
TL;DR: Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation.
Abstract: The genome of Aspergillus oryzae, a fungus important for the production of traditional fermented foods and beverages in Japan, has been sequenced. The ability to secrete large amounts of proteins and the development of a transformation system have facilitated the use of A. oryzae in modern biotechnology. Although both A. oryzae and Aspergillus flavus belong to the section Flavi of the subgenus Circumdati of Aspergillus, A. oryzae, unlike A. flavus, does not produce aflatoxin, and its long history of use in the food industry has proved its safety. Here we show that the 37-megabase (Mb) genome of A. oryzae contains 12,074 genes and is expanded by 7-9 Mb in comparison with the genomes of Aspergillus nidulans and Aspergillus fumigatus. Comparison of the three aspergilli species revealed the presence of syntenic blocks and A. oryzae-specific blocks (lacking synteny with A. nidulans and A. fumigatus) in a mosaic manner throughout the genome of A. oryzae. The blocks of A. oryzae-specific sequence are enriched for genes involved in metabolism, particularly those for the synthesis of secondary metabolites. Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation.
1,149 citations
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TL;DR: The isoflavone aglycones were absorbed faster and in greater amounts than their glucosides in humans and may be more effective than glucoside-rich products in preventing chronic disease such as coronary heart disease.
Abstract: Isoflavones are contained in soybean or soy foods in two chemical forms, i.e., aglycones and glucosides. We investigated the difference in the absorption of soy isoflavone aglycones and glucosides in humans. After a single, low dose intake (0.11 mmol), the highest isoflavone concentrations in plasma were reached 2 and 4 h after ingestion of aglycones and glucosides, respectively; subjects were four men (41 y old) and four women (45 y old). The highest plasma concentration after aglycone intake was more than two times greater than that after glucoside ingestion. In a similar manner, we then compared the plasma isoflavone concentration profiles after intake of a single, high dose of isoflavones (1.7 mmol) in eight subjects (four men, 40 y old; four women, 47 y old) and found the highest plasma concentration after aglycone intake was more than five times higher than that after glucoside intake. In both high and low dose intake tests, the plasma concentration of genistein was significantly higher than that of daidzein despite the similar levels of intake. After long-term (4 wk) intakes (0.30 mmol/d), we also measured the plasma concentration of isoflavones (eight men, 45 y old). After 2 and 4 wk, these concentrations remained >100% higher after ingestion of aglycones than of glucosides. The isoflavone aglycones were absorbed faster and in greater amounts than their glucosides in humans. Isoflavone aglycone-rich products may be more effective than glucoside-rich products in preventing chronic disease such as coronary heart disease.
895 citations
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TL;DR: In a phenazine methosulfate/NADH-nitroblue tetrazolium system, garcinol exhibited superoxide anion scavenging activity and suppressed protein glycation in a bovine serum albumin/fructose system, suggesting it might be beneficial as a potent antioxidant and a glycation inhibitor under specified conditions.
Abstract: Garcinol, a polyisoprenylated benzophenone derivative, was purified from Garcinia indica fruit rind, and its antioxidative activity, chelating activity, free radical scavenging activity, and anti-glycation activity were studied. Garcinol exhibited moderate antioxidative activity in the micellar linoleic acid peroxidation system and also exhibited chelating activity at almost the same level as citrate. It also showed nearly 3 times greater DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging activity than DL-alpha-tocopherol by weight in aqueous ethanol solution. In a phenazine methosulfate/NADH-nitroblue tetrazolium system, garcinol exhibited superoxide anion scavenging activity and suppressed protein glycation in a bovine serum albumin/fructose system. Thus, garcinol might be beneficial as a potent antioxidant and a glycation inhibitor under specified conditions.
480 citations
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TL;DR: Results suggested that proanthocyanidins, the major polyphenols in red wine, might trap reactive oxygen species in aqueous series such as plasma and interstitial fluid of the arterial wall, thereby inhibiting oxidation of LDL and showing an antiatherosclerotic activity.
359 citations
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TL;DR: In this paper, the antiulcer activity of grape seed extracts (GSE-I and GSE-II) and procyanidin oligomers was investigated using rats.
Abstract: It is known that procyanidins, which are contained in grape seeds, are antioxidative and have certain biological effects. Antiulcer activities of grape seed extracts (GSE-I and GSE-II) and procyanidins were investigated using rats. GSE-I (with low flavanol content), GSE-II (with high flavanol content), and procyanidins at a dose of 200 mg/kg strongly inhibited the stomach mucosal injury induced by 60% ethanol containing 150 mM hydrochloride. This suppressive effect seems dependent on the content of procyanidin oligomers. Procyanidin oligomers (dimers to hexamers) were prepared and studied for their antiulcer activities at a dose of 200 mg/kg. The gastric protective activity of a series of procyanidins increased with the increasing polymerization of catechin units. Oligomers longer than tetramers showed a strong protective effect against gastric mucosal damage. The binding ability of procyanidin oligomers to bovine serum albumin in the acidified solution was strengthened with the increase of molecules. The...
341 citations
Authors
Showing all 663 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hiroshi Maeda | 103 | 893 | 63370 |
Kazuhiro Imai | 56 | 301 | 10686 |
Hideki Kambara | 37 | 241 | 5332 |
Masayuki Machida | 35 | 145 | 7989 |
Guohua Zhou | 32 | 319 | 3903 |
Noriko M. Tsuji | 29 | 76 | 3029 |
Yoshiteru Ida | 29 | 133 | 2495 |
Yasuji Koyama | 26 | 101 | 2952 |
Akio Obata | 25 | 103 | 2912 |
Keietsu Abe | 23 | 58 | 1574 |
Naoki Kajiyama | 23 | 65 | 1502 |
Tamotsu Yokotsuka | 20 | 65 | 1005 |
Toshiaki Ariga | 20 | 46 | 2685 |
Kenji S. Nakahara | 19 | 47 | 3335 |
Hiroshi Motai | 17 | 70 | 893 |