Lankenau Medical Center

About: Lankenau Medical Center is a healthcare organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Atrial fibrillation & Medicine. The organization has 436 authors who have published 414 publications receiving 7095 citations. The organization is also known as: Lankenau Hospital.

Abstract P5-13-01: Association between breastfeeding and breast cancer risk by receptor status: A meta-analysis

Abstract: Background: The rising incidence of breast cancer is mainly due to changes in reproductive, lifestyle, and environmental factors, not inherited genetic mutations. Many risk factors can be modified, offering important opportunities for prevention. In the era of personalized care, treatment is subtype dependent. While most prevention strategies are not subtype specific, we wanted to see if breastfeeding confers the same protection based on subtype, especially against poorer prognostic subtypes. Methodology: Relevant articles from case-control or prospective studies were identified by searching PubMed and Scopus databases through 2013 and reference lists of relevant articles. Two researchers independently did the search and evaluated the articles. The summary risk estimates and 95% confidence intervals were calculated using random effects models (DerSimonian-Laird method) for the association between breastfeeding and breast cancer by receptor status. The reference category in most of the studies was never breastfeeding, but in a few studies this also included women who breastfed for a short time. Results: This meta-analysis of 26 articles (20 from case-control, 6 from prospective studies) published between 1983 and 2013 included 34,479 women with invasive breast cancer from 8 countries. Breastfeeding was inversely associated with breast cancer risk across all combination of subtypes: ER+ or -, PR+ or -, HER2+ or -. The relative risk reduction ranged from 12–29% when only the results adjusted for age, body mass index (BMI), parity, and family history of breast cancer were included. There did not appear to be a differential protective benefit of breastfeeding based on subtype using ever vs never analysis. (A breastfeeding dose response analysis by subtype is in progress.) Conclusion: Breastfeeding is a powerful strategy to reduce breast cancer risk, with a relative risk reduction of 12–29%. This benefit is larger than previously reported and was independent of hormone- and HER2-receptor status, suggesting mechanisms of action independent from these receptors and their ligands. To maximize breastfeeding use for the long-term health of mothers and babies, it is important to remove barriers in the home, community, and workplace as well as provide education and support before and after delivery. Citation Format: Marisa Weiss, Ying Liu, Paolo Boffetta, Graham Colditz, Ahmedin Jemel, Farhad Islami. Association between breastfeeding and breast cancer risk by receptor status: A meta-analysis [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P5-13-01.

Chapter 12 – Principles of Cytotoxic Chemotherapy

Abstract: While the use of targeted therapies such as monoclonal antibodies, tyrosine kinase inhibitors and immunotherapies is increasing in medical oncology, the cornerstone of therapy in both the curative and palliative settings remains cytotoxic chemotherapy. This chapter will review the core principles of combination chemotherapy including scheduling, dosing and clinical uses. In addition, a brief overview of resistance to therapy and a general overview of commonly used medications is provided.

Public Awareness of a Plant-Based Diet Following the Release of “Game Changers” and “What The Health” Documentaries:

Abstract: Background: Poor diet is a leading cause of premature death and thus diet and lifestyle changes are needed; yet, no consensus exists regarding diets that provide the greatest benefit. One of these ...

Anatomical characteristics of the membranous septum are predictive of pacemaker requirement in patients undergoing transcatheter aortic valve replacement.

Abstract: We aimed to study the characteristics of the membranous septum (MS) and its relationship with the aortic valve (AoV) and aortic annulus (AA) in patients who required PPM post-TAVR. We performed a retrospective case–control study of 144 patients undergoing TAVR from 2016 to 2018. Thirty-four patients, requiring PPM implantation, were compared with 34 matched controls who did not require pacing. The total MS length, supra-annular MS (SA-MS) length, infra-annular MS (IA-MS) length, angle between the plane of the AA and MS (AA-MS), and degree of AoV calcifications (AVC) were obtained from preoperative CT. AoV prosthesis implantation depth was obtained from intra-operative fluoroscopy. There were no significant differences in valve type (self-expandable: 23 cases vs 25 controls, and balloon-expandable: 11 vs 9, p = 0.79), degree of AVC (0.65 cm3 vs 0.82 cm3, p = 0.62), or implantation depth (7.76 mm vs 7.28 mm, p = 0.83). Compared to controls, there was no difference in total MS length (6.68 mm vs 6.06 mm, p = 0.97), but the IA-MS was significantly shorter (3.64 mm vs 4.56 mm, p = 0.02) and the SA-MS was significantly longer (2.73 mm vs 1.67 mm, p = 0.02) in patients requiring PPM. Patients requiring PPM also had a larger AA-MS angle (103.5° vs 96.7°, p = 0.01). The position of the MS with respect to the AA and MS distance below the annular plane were more closely associated with post-TAVR conduction abnormalities requiring PPM than the absolute length of the MS. Patients undergoing TAVR with such anatomy have a higher risk of requiring PPM and should be monitored for developing these complications.