Institution
Lankenau Medical Center
Healthcare•Philadelphia, Pennsylvania, United States•
About: Lankenau Medical Center is a healthcare organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Atrial fibrillation & Medicine. The organization has 436 authors who have published 414 publications receiving 7095 citations. The organization is also known as: Lankenau Hospital.
Topics: Atrial fibrillation, Medicine, Cancer, Warfarin, Stroke
Papers
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University of Pennsylvania1, University of Rochester2, Georgetown University3, Peter MacCallum Cancer Centre4, Carolinas Healthcare System5, Dartmouth–Hitchcock Medical Center6, Cleveland Clinic7, Duke University8, Fred Hutchinson Cancer Research Center9, Pennsylvania State University10, University of Pittsburgh11, Cornell University12, Georgetown University Medical Center13, Pennsylvania Hospital14, MedStar Washington Hospital Center15, Lankenau Medical Center16, Tufts Medical Center17
TL;DR: Patients starting at lower doses of ibrutinib appear to have inferior PFS, unlike in high-risk heavily pretreated patients, and the PFS of patients receiving front-line ibrUTinib was not adversely affect by dose interruptions of ≥ 8 days.
7 citations
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TL;DR: A 51-year-old Romanian male without a significant past medical history presents with shortness of breath, bilateral lower extremity swelling and right upper extremities swelling and pain and is anticoagulated with intravenous heparin.
Abstract: A 51-year-old Romanian male without a significant past medical history presents with shortness of breath, bilateral lower extremity swelling and right upper extremity swelling and pain. Doppler ultrasound confirmed an extensive right upper extremity Deep Vein Thrombosis (DVT). He was anticoagulated with intravenous heparin. He developed hemodynamic instability on Day 2 of hospitalization and required vasopressors. A left femoral triple lumen catheter was placed urgently. Computed tomography (CT) angiography of the chest excluded pulmonary embolism. A transthoracic echocardiogram revealed severely impaired left ventricular function with an ejection fraction of 10%. …
7 citations
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TL;DR: A prospective study is detailed to test the hypothesis that using PK/QTc modeling in a single ascending dose design study, such as is typically performed in the first-in-human study (FIM), will be sufficiently sensitive to detect QTc effects, to be acceptable in lieu of the thorough QT (TQT) study.
Abstract: In response to concerns regarding the public health implications of drugs being approved that have a proclivity to cause the potentially lethal ventricular arrhythmia torsade de pointes (TdP), there was an international regulatory call to action in 2001. This culminated in the 2005 International Committee on Harmonization (ICH) ICH E-14 guidance “The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs.”1,2 Since then, almost all new chemical entities with systemic exposure have undergone a dedicated study to determine the potential of the compound to prolong the QTc interval. A “positive finding” in this resource-intensive study can have a major impact on the remainder of a drug’s development (e.g., extensive ECG assessments during phase 3, potential approval delays, etc.) and, in some cases, has resulted in termination of the development program. The article by Darpo and colleagues3 in this Journal details a prospective study to test the hypothesis that using PK/QTc modeling in a single ascending dose design study, such as is typically performed in the first-in-human study (FIM), will be sufficiently sensitive to detect QTc effects, to be acceptable in lieu of the thorough QT (TQT) study. Reasons to be optimistic that this important effort is likely to be successful include the fact that careful core-lab analyzed ECG assessments in phase 1 is an approach that is already being
7 citations
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University of Chicago1, Duke University2, Columbia University Medical Center3, Georgetown University4, Hackensack University Medical Center5, Cleveland Clinic6, University of Rochester Medical Center7, Pennsylvania State University8, Lankenau Medical Center9, University of Pennsylvania10, University of Rochester11
TL;DR: Toxicity remains the most common reason for idelalisib discontinuation followed by CLL progression, and data suggests toxicity may be minimized when treatment duration was limited to less than 6 months since many treatment-limiting toxicities occurred beyond that time point.
7 citations
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TL;DR: The first reported case of pseudomonal endocarditis of a MitraClip® in a non-IV drug user is presented.
7 citations
Authors
Showing all 440 results
Name | H-index | Papers | Citations |
---|---|---|---|
Abass Alavi | 113 | 1298 | 56672 |
Robert T. Sataloff | 51 | 680 | 10252 |
Flemming Forsberg | 49 | 333 | 9769 |
Michael D. Ezekowitz | 43 | 164 | 16799 |
Gan-Xin Yan | 42 | 105 | 10110 |
William A. Gray | 41 | 135 | 6830 |
Peter D. Le Roux | 36 | 81 | 4522 |
James M. Mullin | 35 | 98 | 4095 |
Georgia Panagopoulos | 32 | 102 | 3250 |
Karen Chiswell | 30 | 132 | 3477 |
Peter R. Kowey | 29 | 113 | 3083 |
Tracey L. Evans | 29 | 97 | 4465 |
Pietro Delise | 27 | 103 | 5080 |
Caleb B. Kallen | 24 | 44 | 3517 |
Louis E. Samuels | 23 | 95 | 2380 |