Mangalayatan University

About: Mangalayatan University is a education organization based out in Aligarh, Uttar Pradesh, India. It is known for research contribution in the topics: Epitope & Population. The organization has 99 authors who have published 106 publications receiving 1697 citations.

Resealed Erythrocytes as a Carrier for Drug Targeting: A Review

Abstract: Erythrocytes are the most abundant cells in the human body (~5.4 million cells/mm3 blood in a healthy male and ~ 4.8 million cells/mm3 blood in a healthy female) having potential carrier capabilities for the delivery of drugs and drug loaded microspheres. Drug-loaded carrier erythrocytes (resealed erythrocytes) are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers. encouraging the use of erythrocytes in drug delivery include various advantages like as remarkable degree of biocompatibility, Complete biodegradability, lack of toxic product, controllable life-span, decreasing drug side effects etc. In this review we discuss about Resealing of erythrocytes, various techniques of drug loading such as hypotonic hemolysis, hypotonic dilution, hypotonic pre-swelling, isotonic osmoticlysis, Chemical perturbation of the membrane, Electro-insertion, Entrapment by endocytosis etc. and it’s applications in various fields of human and veterinary medicine. Key Words: Resealed erythrocytes, Carrier, Drug loading, Electro-insertion.

A Review- Emerging Use of Nano-Based Carriers in Diagnosis and Treatment of Cancer-Novel Approaches

Abstract: Despite intensive research efforts, cancer remains one of the leading causes of death in the world. Many new methods and techniques have been developed in order to improve diagnosis and treatment, often promising in the beginning, but with limited results during the course of their application. In recent years, there has been an unprecedented expansion in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer. Nanoparticles have unique biological properties given their small size and large surface area-to-volume ratio, which allows them to bind, absorb, and carry compounds such as small molecule drugs, DNA, RNA, proteins, and probes with high efficiency. Their tunable size, shape, and surface characteristics also enable them to have high stability, high carrier capacity, the ability to incorporate both hydrophilic and hydrophobic substances and compatibility with different administration routes, thereby making them highly attractive in many aspects of oncology. The expansion of novel nanoparticles for drug delivery is an exciting and challenging research filed, in particular for the delivery of emerging cancer therapies, including small interference RNA (siRNA) and microRNA (miRNAs)-based molecules.

Structural characterisation of 5-hydroxytryptamine2a receptor in homo sapiens by in - silico method

Abstract: Objective: Structural characterization of 5-hydroxytryptamine (5-HT)2A receptor in homo sapiens using in silico method.Methods: In silico approach has particularly providing a realistic representation needed to understand the fundamental molecular structure of a serotonin receptor. The structure has been generated using Swiss model, Modeller 9.14, Phyre2, and Geno three-dimensional, which was visualized using PyMol, and validated by Procheck and ERRAT analysis along with the values of different secondary structures mapping to diverse sections of the Ramachandran plot.Results: We compared all different models. Further structural analysis suggested that the structure of 5-HT2A is a monomer with 18 alpha helices, seven beta sheets, and one disulfide bridge. There is no signal peptide region in the protein sequence. The structure contains mostly polar and aromatic amino acid as suggested by using hydropathy plot. However, in both partitioning systems bilayer to water and water to bilayer, there are some hydropathy predicted segments, which are also transmembrane segments. Finally, the pore features, including diameter profile, size, and shape, were determined by porewalker, and the shape of the pore was found to be UDSD.Conclusion: This study suggested that 5-HT2A receptor interaction with its natural ligand serotonin and other inhibitor compounds would further additional information about G protein-coupled receptors. The 5-HT2A receptor could be an important target for therapeutics development.

The 27-day periodicity and its sub harmonics

Abstract: Significant short-term variations of ≈1.7, ≈2.4, ≈2.8, ≈3.3, ≈3.8 days periods are found when high resolution data (five minutes average) of interplanetary electric field (Ey), south ward component of magnetic field (Bz) and geomagnetic index (AE) is subjected to wavelet analysis. The fourth, fifth, sixth sub harmonics of ≈27-day period, and few other short-term periods are significantly reported by Singh and Badruddin (Astrophys. Space Sci. 359:60, 2015a; Solar Phys. 290:3071, 2015b and Solar Phys. 294:27, 2019) in cosmic ray intensity, geomagnetic activity index and various solar wind plasma and field parameters. The reported and observed periods ≈6.8 day, ≈5.5 day, ≈4.4 day, ≈3.9 day, ≈3.4 day, ≈3.0 day, ≈2.8 day, ≈2.4 day, ≈2.2 day, ≈2.0 day, ≈1.9 day, ≈1.8 day; and ≈1.7 day are close to integral multiples of 1/4, 1/5, 1/6, 1/7, 1/8, 1/9, 1/10, 1/11, 1/12, 1/13, 1/14, 1/15 and 1/16 of one solar rotation period (≈27.0 day), hence these periods could be sub harmonics of fundamental period (≈27 day). If so, then these results lead to infer some sort of continuous simultaneous oscillations of active regions having integral multiple frequencies and varying amplitudes occurring on the solar disc.