Institution
North Bristol NHS Trust
Healthcare•Bristol, United Kingdom•
About: North Bristol NHS Trust is a healthcare organization based out in Bristol, United Kingdom. It is known for research contribution in the topics: Population & Medicine. The organization has 2204 authors who have published 2811 publications receiving 61110 citations.
Papers published on a yearly basis
Papers
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TL;DR: Staphylococcus aureus strains from the U.S. SENTRY Antimicrobial Surveillance Program, GISA, and heterogeneous GISA strains were used to compare bactericidal activities of daptomycin and vancomycin using MICs and minimum bactericidal concentrations.
Abstract: Received 2 June 2006/Returned for modification 7 July 2006/Accepted 6 October 2006 Staphylococcus aureus strains from the U.S. SENTRY Antimicrobial Surveillance Program, 2002-2003, glycopeptide-intermediate S. aureus (GISA) strains, and heterogeneous GISA (hGISA) strains were used to compare bactericidal activities of daptomycin and vancomycin using MICs and minimum bactericidal concentrations. Glycopeptide-susceptible S. aureus and hGISA strains were further studied by using time-kill curves. For all isolates, the daptomycin MIC50 and MIC90 are four times lower and the log drops in viable counts at 6 h and 24 h are significantly greater than those for vancomycin.
66 citations
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TL;DR: Multimorbidity showed no associations across a range of outcome measures, as it is currently defined, and should not be relied on as a useful clinical tool in guidelines or policies for older emergency surgical patients.
Abstract: Objectives Multimorbidity is the presence of 2 or more medical conditions. This increasingly used assessment has not been assessed in a surgical population. The objectives of this study were to assess the prevalence of multimorbidity and its association with common outcome measures.
Design A cross-sectional observational study.
Setting A UK-based multicentre study, included participants between July and October 2014.
Participants Consecutive emergency (non-elective) general surgical patients admitted to hospital, aged over 65 years.
Outcome measures The outcome measures were (1) the prevalence of multimorbidity and (2) the association between multimorbidity and frailty; the rate and severity of surgery; length of hospital stay; readmission to hospital within 30 days of discharge; and death at 30 and 90 days.
Results Data were collected on 413 participants aged 65–98 years (median 77 years, (IQR (70–84)). 51.6% (212/413) participants were women. Multimorbidity was present in 74% (95% CI 69.7% to 78.2%) of the population and increased with age (p<0.0001). Multimorbidity was associated with increasing frailty (p for trend <0.0001). People with multimorbidity underwent surgery as often as those without multimorbidity, including major surgery (p=0.03). When comparing multimorbid people with those without multimorbidity, we found no association between length of hospital stay (median 5 days, IQR (1–54), vs 6 days (1–47), (p=0.66)), readmission to hospital (64 (21.1%) vs 18 (16.8%) (p=0.35)), death at 30 days (14 (4.6%) vs 6 (5.6%) (p=0.68)) or 90-day mortality (28 (9.2%) vs 8 (7.6%) (p=0.60)).
Conclusions and implications Multimorbidity is common. Nearly three-quarters of this older emergency general surgical population had 2 or more chronic medical conditions. It was strongly associated with age and frailty, and was not a barrier to surgical intervention. Multimorbidity showed no associations across a range of outcome measures, as it is currently defined. Multimorbidity should not be relied on as a useful clinical tool in guidelines or policies for older emergency surgical patients.
66 citations
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TL;DR: The purpose of this article is to provide a comprehensive and informed list of the end-user requirements for the development of new generation robot- and computer-assisted surgical systems and the methodology for eliciting them.
Abstract: The robotic surgical systems and computer-assisted technologies market has seen impressive growth over the last decades, but uptake by end-users is still scarce. The purpose of this article is to p...
66 citations
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TL;DR: Guidelines to best practice management of 22q11DS based on a literature review and consensus have been developed by a national group of professionals with consideration of the limitations of available medical and educational resources.
Abstract: The commonest autosomal deletion, 22q11.2 deletion syndrome (22q11DS) is a multisystem disorder varying greatly in severity and age of identification between affected individuals. Holistic care is best served by a multidisciplinary team, with an anticipatory approach. Priorities tend to change with age, from feeding difficulties, infections and surgery of congenital abnormalities particularly of the heart and velopharynx in infancy and early childhood to longer-term communication, learning, behavioural and mental health difficulties best served by evaluation at intervals to consider and initiate management. Regular monitoring of growth, endocrine status, haematological and immune function to enable early intervention helps in maintaining health. Conclusion: Guidelines to best practice management of 22q11DS based on a literature review and consensus have been developed by a national group of professionals with consideration of the limitations of available medical and educational resources.
65 citations
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TL;DR: Outcomes for patients who undergo cystectomy have improved for all age groups and it is concluded that the continued survival improvements are a result of a combination of service improvements that include service reconfiguration, improved surgical training, neoadjuvant chemotherapy, enhanced recovery principles, and continued improvements in perioperative care.
65 citations
Authors
Showing all 2226 results
Name | H-index | Papers | Citations |
---|---|---|---|
Debbie A Lawlor | 147 | 1114 | 101123 |
Stephen T. Holgate | 142 | 870 | 82345 |
Paul Jackson | 141 | 1372 | 93464 |
E. Thomson | 103 | 992 | 51777 |
Paul Abrams | 91 | 505 | 51539 |
Susan M. Ring | 91 | 268 | 45339 |
Richard Baker | 83 | 514 | 22970 |
Seth Love | 74 | 344 | 30535 |
Kenneth R Fox | 70 | 269 | 19099 |
Evan L. Flatow | 70 | 245 | 15692 |
Paul Roderick | 67 | 392 | 20741 |
Robert J. Hinchliffe | 66 | 298 | 14818 |
Tim Cook | 61 | 340 | 14170 |
Jasmeet Soar | 57 | 252 | 20311 |
Salomone Di Saverio | 55 | 338 | 9123 |