Institution
North Bristol NHS Trust
Healthcare•Bristol, United Kingdom•
About: North Bristol NHS Trust is a healthcare organization based out in Bristol, United Kingdom. It is known for research contribution in the topics: Population & Medicine. The organization has 2204 authors who have published 2811 publications receiving 61110 citations.
Papers published on a yearly basis
Papers
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TL;DR: Exposure to methotrexate (MTX) treatment was not associated with an increased risk of rheumatoid arthritis interstitial lung disease (RA-ILD), and evidence suggested that MTX may delay the onset of ILD.
Abstract: Objectives To assess predictive factors for rheumatoid arthritis interstitial lung disease (RA-ILD) in two early rheumatoid arthritis (RA) inception cohorts with a focus on methotrexate (MTX) exposure. Design Multicentre prospective early RA inception cohort studies; the early RA study (ERAS) and the early RA network (ERAN). Setting Secondary care, ERAS nine centres, ERAN 23 centres in England, Wales and Ireland. Participants Patients with new diagnosis of RA, n=2701. Standardised data including demographics, drug therapies and clinical outcomes including the presence of RA-ILD were collected at baseline, within 3–6 months, at 12 months and annually thereafter. Primary and secondary outcome measures Primary outcome was the association of MTX exposure on RA-ILD diagnosis. Secondary outcomes were the association of demographic, comorbid and RA-specific factors on RA-ILD diagnosis and the association of MTX exposure on time to RA-ILD diagnosis. Results Of 92 eligible ILD cases, 39 occurred in 1578 (2.5%) MTX exposed and 53 in 1114 (4.8%) non-MTX exposed cases. The primary analysis of RA-ILD cases only developing after any conventional synthetic disease-modifying antirheumatic drug treatment (n=67) showed MTX exposure not to be associated with incident RA-ILD (OR 0.85, 95% CI 0.49 to 1.49, p=0.578) and a non-significant trend for delayed ILD diagnosis (OR 0.54, 95% CI 0.28 to 1.06, p=0.072). In an extended analysis including RA-ILD cases present at RA diagnosis (n=92), MTX exposure was associated with a significantly reduced risk of incident RA-ILD (OR 0.48, 95% CI 0.3 to 0.79, p=0.004) and longer time to ILD diagnosis (OR 0.41, 95% CI 0.23 to 0.75, p=0.004). Other independent baseline associations with incident RA-ILD were higher age of RA onset, ever smoking, male gender, rheumatoid nodules and longer time from first RA symptom to first outpatient visit. Conclusions MTX treatment was not associated with an increased risk of RA-ILD diagnosis. On the contrary, evidence suggested that MTX may delay the onset of ILD.
123 citations
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TL;DR: Three sets of criteria to diagnose human death are outlined, somatic, circulatory, and neurological, which represent a diagnostic standard in which the medical profession and the public can have complete confidence.
Abstract: There is growing medical consensus in a unifying concept of human death. All human death involves the irreversible loss of the capacity for consciousness, combined with the irreversible loss of the capacity to breathe. Death then is a result of the irreversible loss of these functions in the brain. This paper outlines three sets of criteria to diagnose human death. Each set of criteria clearly establishes the irreversible loss of the capacity for consciousness, combined with the irreversible loss of the capacity to breathe. The most appropriate set of criteria to use is determined by the circumstances in which the medical practitioner is called upon to diagnose death. The three criteria sets are somatic (features visible on external inspection of the corpse), circulatory (after cardiorespiratory arrest), and neurological (in patients in coma on mechanical ventilation); and represent a diagnostic standard in which the medical profession and the public can have complete confidence. This review unites authors from Australia, Canada, and the UK and examines the medical criteria that we should use in 2012 to diagnose human death.
123 citations
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North Bristol NHS Trust1, Imperial College Healthcare2, University of Texas Southwestern Medical Center3, University of Oslo4, University of Virginia5, University Hospital of Bern6, Boston Children's Hospital7, McGill University8, Beth Israel Deaconess Medical Center9, University of Texas at Arlington10, James Cook University Hospital11, Aarhus University12, University of Iowa13, University of Alberta14, University of Western Australia15, Saginaw Valley State University16, McMaster University17, Great Ormond Street Hospital for Children NHS Foundation Trust18, University of São Paulo19, University of Cologne20, Monash University21, University of Zurich22, Queen's University23, University of Toronto24, University of Pittsburgh25, National Taiwan University26, University of Calgary27, Yonsei University28, Deakin University29, University of Warwick30, North York General Hospital31, Federal University of São Paulo32, University of Southampton33, American Red Cross34, Universidad Peruana de Ciencias Aplicadas35, Rosalind Franklin University of Medicine and Science36, Florey Institute of Neuroscience and Mental Health37, Jichi Medical University38, Kyoto University39, Dalhousie University40, Seoul National University Hospital41, University of Washington42, Denver Health Medical Center43, Singapore General Hospital44, Stanford University45, University of Antwerp46, University of Melbourne47, Children's Hospital of Philadelphia48, University of Michigan49, Waikato Hospital50, Wayne State University51, Liverpool Hospital52, Heart of England NHS Foundation Trust53, Cornell University54, Michigan State University55, University of Milan56, University of Oxford57, Teikyo University58, Catholic University of the Sacred Heart59, University of Arkansas60, University of Birmingham61, University of Helsinki62, University of Oklahoma63, University of Western Ontario64, University of Padua65, Ottawa Hospital Research Institute66, Ghent University67, Vanderbilt University68
TL;DR: This summary addresses the role of cardiac arrest centers and dispatcher-assisted cardiopulmonary resuscitation, the role for presyncope by first aid providers, advanced airway interventions in adults and children, targeted temperature management in children after cardiac arrest, and initial oxygen concentration during resuscitation of newborns.
Abstract: The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the third annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It addresses the most recent published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. This summary addresses the role of cardiac arrest centers and dispatcher-assisted cardiopulmonary resuscitation, the role of extracorporeal cardiopulmonary resuscitation in adults and children, vasopressors in adults, advanced airway interventions in adults and children, targeted temperature management in children after cardiac arrest, initial oxygen concentration during resuscitation of newborns, and interventions for presyncope by first aid providers. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the certainty of the evidence on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence to Decision Framework Highlights sections. The task forces also listed priority knowledge gaps for further research.
121 citations
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TL;DR: MFC-MRD can improve outcome stratification by extending the definition of partial response after first induction and may help predict NPM1-wt standard-risk patients with poor outcome who benefit from transplant in the first CR.
Abstract: PurposeWe investigated the effect on outcome of measurable or minimal residual disease (MRD) status after each induction course to evaluate the extent of its predictive value for acute myeloid leukemia (AML) risk groups, including NPM1 wild-type (wt) standard risk, when incorporated with other induction response criteria.MethodsAs part of the NCRI AML17 trial, 2,450 younger adult patients with AML or high-risk myelodysplastic syndrome had prospective multiparameter flow cytometric MRD (MFC-MRD) assessment. After course 1 (C1), responses were categorized as resistant disease (RD), partial remission (PR), and complete remission (CR) or complete remission with absolute neutrophil count < 1,000/µL or thrombocytopenia < 100,000/μL (CRi) by clinicians, with CR/CRi subdivided by MFC-MRD assay into MRD+ and MRD−. Patients without high-risk factors, including Flt3 internal tandem duplication wt/−NPM1-wt subgroup, received a second daunorubicin/cytosine arabinoside induction; course 2 (C2) was intensified for patie...
120 citations
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TL;DR: Adipose-derived stem cell-enriched lipografts produced aesthetically-acceptable results without the need for repeat treatment sessions, which are necessary with autologous fat transplantation.
120 citations
Authors
Showing all 2226 results
Name | H-index | Papers | Citations |
---|---|---|---|
Debbie A Lawlor | 147 | 1114 | 101123 |
Stephen T. Holgate | 142 | 870 | 82345 |
Paul Jackson | 141 | 1372 | 93464 |
E. Thomson | 103 | 992 | 51777 |
Paul Abrams | 91 | 505 | 51539 |
Susan M. Ring | 91 | 268 | 45339 |
Richard Baker | 83 | 514 | 22970 |
Seth Love | 74 | 344 | 30535 |
Kenneth R Fox | 70 | 269 | 19099 |
Evan L. Flatow | 70 | 245 | 15692 |
Paul Roderick | 67 | 392 | 20741 |
Robert J. Hinchliffe | 66 | 298 | 14818 |
Tim Cook | 61 | 340 | 14170 |
Jasmeet Soar | 57 | 252 | 20311 |
Salomone Di Saverio | 55 | 338 | 9123 |