C
Christopher L. Antos
Researcher at Dresden University of Technology
Publications - 25
Citations - 6852
Christopher L. Antos is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Zebrafish & Muscle hypertrophy. The author has an hindex of 18, co-authored 25 publications receiving 6503 citations. Previous affiliations of Christopher L. Antos include University of Texas Southwestern Medical Center & Max Planck Society.
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Journal ArticleDOI
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Jeffery D. Molkentin,Jeffery D. Molkentin,Jianrong Lu,Christopher L. Antos,Bruce E. Markham,James A. Richardson,Jeffrey Robbins,Stephen R. Grant,Eric N. Olson +8 more
TL;DR: It is shown that cardiac hypertrophy is induced by the calcium-dependent phosphatase calcineurin, which dephosphorylates the transcription factor NF-AT3, enabling it to translocate to the nucleus.
Journal ArticleDOI
Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
Magdalena Juhaszova,Dmitry B. Zorov,Dmitry B. Zorov,Suhn-Hee Kim,Suhn-Hee Kim,Salvatore Pepe,Salvatore Pepe,Qin Fu,Kenneth W. Fishbein,Bruce D. Ziman,Su Wang,Kirsti Ytrehus,Christopher L. Antos,Eric N. Olson,Steven J. Sollott +14 more
TL;DR: It is shown that reoxygenation after prolonged hypoxia reduces the reactive oxygen species (ROS) threshold for the mitochondrial permeability transition (MPT) in cardiomyocytes and that cell survival is steeply negatively correlated with the fraction of depolarized mitochondria.
Journal ArticleDOI
Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy
Chun Li Zhang,Timothy A. McKinsey,Shurong Chang,Christopher L. Antos,Joseph A. Hill,Eric N. Olson +5 more
TL;DR: It is shown that class II HDACs are substrates for a stress-responsive kinase specific for conserved serines that regulate MEF2-HDAC interactions, and act as signal-responsive suppressors of the transcriptional program governing cardiac hypertrophy and heart failure.
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Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Christopher L. Antos,Timothy A. McKinsey,Norbert Frey,William Kutschke,John R. McAnally,John M. Shelton,James A. Richardson,Joseph A. Hill,Eric N. Olson +8 more
TL;DR: A role for GSK-3β is revealed as an inhibitor of hypertrophic signaling in the intact myocardium and it is suggested that elevation of cardiac GSK -3β activity may provide clinical benefit in the treatment of pathologic hypertrophy and heart failure.
Journal ArticleDOI
A role for cadherins in tissue formation
Lionel Larue,Christopher L. Antos,Stefan Butz,Otmar Huber,Véronique Delmas,Mara Dominis,Rolf Kemler +6 more
TL;DR: These results provide the first evidence that specific cadherins directly stimulate differentiation into certain types of tissues, including epithelia and cartilage.