Republic of Korea Army

About: Republic of Korea Army is a government organization based out in Daejeon, South Korea. It is known for research contribution in the topics: Crisis communication & Mental health. The organization has 67 authors who have published 74 publications receiving 513 citations. The organization is also known as: ROKA & ROK Army.

Comparison of Pharmacokinetic Characteristics and the Safety between Amlodipine Maleate Tablet 5 mg and Amlodipine Besylate Tablet 5 mg

Abstract: 1 Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, Seoul, Korea, University of Ulsan College of Medicine, School of Military Medicine, The First Republic of Korea Army, Department of Clinical Pharmacology and Therapeutics, Inje University Pusan Paik Hospital, Pusan, Korea, 5 Division of Clinical Pharmacology, Clinical Trials Center, Pusan National University Hospital, Division of Clinical Pharmacology, Clinical Trial Center, Samsung Medical Center, Technical research center, CKD research institute, Chong Kun Dang Pharmaceutical Co, Ltd Background: Amlodipine is a third-generation dihydropyridine calcium channel blocker for treating hypertension. Though marketed primarily as a besylate salt, there have been some efforts to find other comparable salts. Among them, maleate is the salt that has been considered favorable for many drugs. The aim of this study was to compare the pharmacokinetics, as well as safety and tolerability of amlodipine maleate with amlodipine besylate. Methods: This study was open, randomized, two-period crossover design investigated in twelve healthy male volunteers over a 144 h period after administrating two forms of amlodipine 5 mg, respectively. Each period was separated with 2 weeks. Plasma concentrations of amlodipine were determined by liquid chromatography-tandem mass spectrometry. Safety profiles were assessed by vital signs, physical examinations, electrocardiograms, laboratory testing and adverse events monitoring. Results: All subjects were completed this study. Geometric mean ratios (GMRs) of amlodipine maleate/amlodipine besylate of Cmax and AUClast for amlodipine were 0.92 (90 % confidence interval, 0.81 ∼ 1.05) and 1.05 (0.96 ∼ 1.16), respectively. No serious adverse events were reported, and no clinically relevant changes were observed in safety profiles during this trial. Conclusion: Pharmacokinetics, tolerability and the safety were comparable between amlodipine maleate and amlodipine besylate in healthy individuals.

The Effect of Screw Apophysiodesis of Greater Trochanter in Legg-Calve-Perthes Disease

Abstract: “This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.” The Journal of the Korean Orthopaedic Association Volume 53 Number 1 2018 Received October 27, 2016 Revised February 24, 2017 Accepted June 19, 2017 Correspondence to: Hyeon Jun Kim, M.D. Department of Orthopedic Surgery, Dong-A University College of Medicine, 32 Daesingongwon-ro, Seo-gu, Busan 49201, Korea TEL: +82-51-240-2757 FAX: +82-51-254-6757 E-mail: hyeonjun@dau.ac.kr Legg-Calve-Perthes 병에서 나사를 이용한 대전자 골단유합술의 효과

The Changing Security Environment

Abstract: With the demise of the communist regime in the Soviet Union, the world has been experiencing immense changes both in communist nations and in democratic countries. The communist bloc disintegrated in Eastern Europe and the communist leaders lost their positions. Democratic new governments were elected in these former communist countries and this process of democratization continues, even in the former Soviet Union. The symbol of the Cold War, the Berlin Wall, was also demolished and the two Germanies were united. Reflecting the change in the world, the United States has already authorized a major or partial cut in its forces from the former bases of the Cold War.

A Study of Analysis for Noise Environment and Hearing Loss of Army Aviation Pilots

Abstract: Kyucheol Ko, Oyonghyeok Lee, Jinsook Kim, Taewon Lee, Yerim Shin, Hyesook Lee Republic of Korea Army Aviation School Combat Development Department, Nonsan, Korea Department of Speech Pathology and Audiology, Graduate School, Hallym University, Chuncheon, Korea Division of Speech Pathology and Audiology, College of Natural Sciences, Hallym University, Chuncheon, Korea Division of Mathematical Sciences, Sejong Campus, Korea University, Sejong, Korea Republic of Korea Force Aerospace Medical Center, Cheongju, Korea