Institution
Royal Surrey County Hospital
Healthcare•Guildford, United Kingdom•
About: Royal Surrey County Hospital is a healthcare organization based out in Guildford, United Kingdom. It is known for research contribution in the topics: Cancer & Population. The organization has 2222 authors who have published 3064 publications receiving 86753 citations.
Topics: Cancer, Population, Prostate cancer, Breast cancer, Mammography
Papers published on a yearly basis
Papers
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TL;DR: The accumulated effect of repeat dexamethasone pellet implantations improves retinal thickness and resolves ocular inflammation, resulting in restoration of ocular function.
117 citations
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TL;DR: Of four evidence-based interventions, the enhanced reminder letter reduced the socioeconomic gradient in screening uptake, but further reducing inequalities in screenings uptake through written materials alone will be challenging.
117 citations
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TL;DR: With the increasing use of rituximab, it is important for clinicians treating patients to be aware of hypogammaglobulinaemia and serious infections occurring even years after completion of treatment and should be actively looked for during follow-up.
Abstract: Background: Rituximab, a chimeric monoclonal antibody against CD20, is increasingly used in the treatment of B-cell lymphomas and autoimmune conditions. Transient peripheral B-cell depletion is expected following rituximab therapy. Although initial clinical trials did not show significant hypogammaglobulinaemia, reports of this are now appearing in the literature.
Methods: We performed a retrospective review of patients previously treated with rituximab that were referred to Clinical Immunology with symptomatic or severe hypogammaglobulinaemia. Patient clinical histories, immunological markers, length of rituximab treatment and need for intravenous immunoglobulin replacement therapy (IVIG) were evaluated. An audit of patients receiving rituximab for any condition in a 12-month period and frequency of hypogammaglobulinaemia was also carried out.
Results: We identified 19 post-rituximab patients with persistent, symptomatic panhypogammaglobulinaemia. Mean IgG level was 3.42 ± 0.4 g/l (normal range 5.8–16.3 g/l). All patients had reduced or absent B-cells. Haemophilus Influenzae B, tetanus and Pneumococcal serotype-specific antibody levels were all reduced and patients failed to mount an immune response post-vaccination. Nearly all of them ultimately required IVIG. The mean interval from the last rituximab dose and need for IVIG was 36 months (range 7 months–7 years). Of note, 23.7% of 114 patients included in the audit had hypogammaglobulinaemia.
Conclusion: With the increasing use of rituximab, it is important for clinicians treating these patients to be aware of hypogammaglobulinaemia and serious infections occurring even years after completion of treatment and should be actively looked for during follow-up. Referral to clinical immunology services and, if indicated, initiation of IVIG should be considered.
117 citations
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TL;DR: Cytological smears prepared from fine needle aspiration biopsies of prostatic carcinoma were subjected to cytophotometric DNA analysis and some of the tumours exhibited clearly aneuploid modal distribution patterns with DNA values ranging from the hypotriploidlevel to the hypertetraploid level, while in other tumours a large intercellular variability in DNA content was the characteristic feature.
Abstract: In this month’s issue of SJUN Wang and colleagues analyzed cancer-specific survival (CSS) in patients with high-risk non-muscle invasive bladder cancer (HR NMIBC) following treatment with either BC...
117 citations
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TL;DR: This review summarises and highlights the computational challenges of the γ calculation and sheds light on some of these issues by means of a bespoke MATLAB software to demonstrate the impact of interpolation, γ search distance, resolution and 2D and 3D calculations.
115 citations
Authors
Showing all 2225 results
Name | H-index | Papers | Citations |
---|---|---|---|
Aroon D. Hingorani | 111 | 428 | 59171 |
Stephen W. Duffy | 95 | 630 | 38987 |
Stanley W. Ashley | 83 | 498 | 29893 |
Sarah C. Darby | 77 | 244 | 57679 |
Justin Stebbing | 68 | 633 | 18697 |
Susan Lightman | 63 | 401 | 14065 |
Stephen Taylor | 62 | 549 | 16906 |
Edward Chow | 59 | 512 | 14303 |
Hardev Pandha | 57 | 349 | 11617 |
Gordon A. Ferns | 55 | 726 | 14744 |
Vincent Marks | 52 | 332 | 10947 |
Gary Middleton | 47 | 161 | 12552 |
David Russell-Jones | 47 | 154 | 7101 |
David E. Ward | 47 | 236 | 7934 |
Martin G. Cook | 40 | 108 | 5237 |