G
Gary Middleton
Researcher at University of Birmingham
Publications - 175
Citations - 16508
Gary Middleton is an academic researcher from University of Birmingham. The author has contributed to research in topics: Cancer & Capecitabine. The author has an hindex of 47, co-authored 161 publications receiving 12552 citations. Previous affiliations of Gary Middleton include Royal Surrey County Hospital & University of Cambridge.
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Journal ArticleDOI
Tracking the Evolution of Non–Small-Cell Lung Cancer
Mariam Jamal-Hanjani,Gareth A. Wilson,Nicholas McGranahan,Nicolai Juul Birkbak,Thomas B.K. Watkins,Selvaraju Veeriah,Seema Shafi,Diana Johnson,Richard Mitter,Rachel Rosenthal,Max Salm,Stuart Horswell,Mickael Escudero,Nik Matthews,Andrew Rowan,Tim Chambers,David A. Moore,Samra Turajlic,Hang Xu,Siow Ming Lee,Martin Forster,Tanya Ahmad,Crispin T. Hiley,Christopher Abbosh,Mary Falzon,Elaine Borg,Teresa Marafioti,David Lawrence,Martin Hayward,Shyam Kolvekar,Nikolaos Panagiotopoulos,Sam M. Janes,Ricky Thakrar,Asia Ahmed,Fiona H Blackhall,Yvonne Summers,Rajesh Shah,Leena Dennis Joseph,Anne Marie Quinn,Phil Crosbie,Babu Naidu,Gary Middleton,Gerald Langman,Simon Trotter,Marianne Nicolson,Hardy Remmen,Keith Kerr,Mahendran Chetty,Lesley Gomersall,Dean A. Fennell,Apostolos Nakas,Sridhar Rathinam,Girija Anand,Sajid A. Khan,Peter Russell,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Jason F. Lester,Malgorzata Kornaszewska,Richard Attanoos,Haydn Adams,Helen Davies,Stefan C. Dentro,Philippe Taniere,Brendan O'Sullivan,Helen Lowe,John A. Hartley,Natasha Iles,Harriet Bell,Yenting Ngai,Jacqui Shaw,Javier Herrero,Zoltan Szallasi,Roland F. Schwarz,Aengus Stewart,Sergio A. Quezada,John Le Quesne,Peter Van Loo,Caroline Dive,Allan Hackshaw,Charles Swanton +82 more
TL;DR: Intratumor heterogeneity mediated through chromosome instability was associated with an increased risk of recurrence or death, a finding that supports the potential value of chromosome instability as a prognostic predictor.
Journal ArticleDOI
Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial
John P. Neoptolemos,John P. Neoptolemos,Daniel H. Palmer,Daniel H. Palmer,Paula Ghaneh,Eftychia E. Psarelli,Juan W. Valle,Christopher Halloran,Christopher Halloran,Olusola Olusesan Faluyi,Derek A. O'Reilly,David Cunningham,Jonathan Wadsley,Suzanne Darby,Tim Meyer,Roopinder Gillmore,Alan Anthoney,Pehr Lind,Bengt Glimelius,Stephen Falk,Jakob R. Izbicki,Gary Middleton,Sebastian Cummins,Paul Ross,Harpreet Wasan,Alec McDonald,Tom Crosby,Yuk Ting Ma,Kinnari Patel,David Sherriff,Rubin Soomal,David Borg,Sharmila Sothi,Pascal Hammel,Thilo Hackert,Richard J. Jackson,Markus W. Büchler +36 more
TL;DR: The adjuvant combination of gem citabine and capecitabine should be the new standard of care following resection for pancreatic ductal adenocarcinoma.
Journal ArticleDOI
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
Christopher Abbosh,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Gareth A. Wilson,Gareth A. Wilson,Mariam Jamal-Hanjani,Tudor Constantin,Raheleh Salari,John Le Quesne,David A. Moore,Selvaraju Veeriah,Rachel Rosenthal,Teresa Marafioti,Eser Kirkizlar,Thomas B.K. Watkins,Thomas B.K. Watkins,Nicholas McGranahan,Nicholas McGranahan,Sophia Ward,Sophia Ward,Luke Martinson,Joan Riley,Francesco Fraioli,Maise Al Bakir,Eva Grönroos,Francisco Zambrana,Raymondo Endozo,Wenya Linda Bi,Wenya Linda Bi,Fiona M. Fennessy,Fiona M. Fennessy,Nicole Sponer,Diana Johnson,Joanne Laycock,Seema Shafi,Justyna Czyzewska-Khan,Andrew Rowan,Tim Chambers,Nik Matthews,Nik Matthews,Samra Turajlic,Samra Turajlic,Crispin T. Hiley,Crispin T. Hiley,Siow Ming Lee,Martin Forster,Tanya Ahmad,Mary Falzon,Elaine Borg,David Lawrence,Martin Hayward,Shyam Kolvekar,Nikolaos Panagiotopoulos,Sam M. Janes,Ricky Thakrar,Asia Ahmed,Fiona H Blackhall,Yvonne Summers,Dina Hafez,Ashwini Naik,Apratim Ganguly,Stephanie Kareht,Rajesh Shah,Leena Dennis Joseph,Anne Marie Quinn,Phil Crosbie,Babu Naidu,Gary Middleton,Gerald Langman,Simon Trotter,Marianne Nicolson,Hardy Remmen,Keith M. Kerr,Mahendran Chetty,Lesley Gomersall,Dean A. Fennell,Apostolos Nakas,Sridhar Rathinam,Girija Anand,Sajid Khan,Peter Russell,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Jason F. Lester,Malgorzata Kornaszewska,Richard Attanoos,Haydn Adams,Helen E. Davies,Dahmane Oukrif,Ayse U. Akarca,John A. Hartley,Helen Lowe,Sara Lock,Natasha Iles,Harriet Bell,Yenting Ngai,Greg Elgar,Zoltan Szallasi,Zoltan Szallasi,Zoltan Szallasi,Roland F. Schwarz,Javier Herrero,Aengus Stewart,Sergio A. Quezada,Karl S. Peggs,Peter Van Loo,Peter Van Loo,Caroline Dive,Caroline Dive,C. Jimmy Lin,Matthew Rabinowitz,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts,Allan Hackshaw,Jacqui Shaw,Bernhard Zimmermann,Charles Swanton,Charles Swanton +119 more
TL;DR: It is shown that phylogenetic ct DNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.
Journal ArticleDOI
EPIC: Phase III Trial of Cetuximab Plus Irinotecan After Fluoropyrimidine and Oxaliplatin Failure in Patients With Metastatic Colorectal Cancer
Alberto Sobrero,Joan Maurel,Louis Fehrenbacher,Werner Scheithauer,Yousif A. Abubakr,Manfred P. Lutz,M. Eugenia Vega-Villegas,Cathy Eng,Ernst U. Steinhauer,Jana Prausova,Heinz-Josef Lenz,Christophe Borg,Gary Middleton,Hendrik Kröning,Gabriele Luppi,O. Kisker,A. Zubel,Christiane Langer,Justin Kopit,Howard A. Burris +19 more
TL;DR: Cetuximab and irinotecan improved PFS and RR, and resulted in better QOL versus irinOTecan alone, and did not exacerbate toxicity, except for acneform rash, diarrhea, hypomagnesemia, and associated electrolyte imbalance.
Journal ArticleDOI
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
Nicholas McGranahan,Rachel Rosenthal,Crispin T. Hiley,Crispin T. Hiley,Andrew J. Rowan,Thomas B.K. Watkins,Gareth A. Wilson,Gareth A. Wilson,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Selvaraju Veeriah,Peter Van Loo,Peter Van Loo,Javier Herrero,Charles Swanton,Charles Swanton,Mariam Jamal-Hanjani,Seema Shafi,Justyna Czyzewska-Khan,Diana Johnson,Joanne Laycock,Leticia Bosshard-Carter,Pat Gorman,Robert E. Hynds,Gareth A. Wilson,Stuart Horswell,Richard Mitter,Mickael Escudero,Aengus Stewart,Andrew Rowan,Hang Xu,Samra Turajlic,Crispin T. Hiley,Christopher Abbosh,Jacki Goldman,Richard Kevin Stone,Tamara Denner,Nik Matthews,Greg Elgar,Sophia Ward,Marta Costa,Sharmin Begum,Ben Phillimore,Tim Chambers,Emma Nye,Sofia Graca,Maise Al Bakir,Kroopa Joshi,Andrew Furness,Assma Ben Aissa,Yien Ning Sophia Wong,Andy Georgiou,Sergio A. Quezada,John A. Hartley,Helen Lowe,David Lawrence,Martin Hayward,Nikolaos Panagiotopoulos,Shyam Kolvekar,Mary Falzon,Elaine Borg,Teresa Marafioti,Celia Simeon,Gemma Hector,Amy Smith,Marie Aranda,Marco Novelli,Dahmane Oukrif,Sam M. Janes,Ricky Thakrar,Martin Forster,Tanya Ahmad,Siow Ming Lee,Dionysis Papadatos-Pastos,Dawn Carnell,Ruheena Mendes,Jeremy George,Neal Navani,Asia Ahmed,Magali Taylor,Junaid Choudhary,Yvonne Summers,Raffaele Califano,Paul D. Taylor,Rajesh Shah,Piotr Krysiak,Kendadai Rammohan,Eustace Fontaine,Richard Booton,Matthew Evison,Phil Crosbie,Stuart Moss,Faiza Idries,Leena Dennis Joseph,Paul N. Bishop,Anshuman Chaturved,Anne Marie Quinn,H. Doran,Angela Leek,Phil Harrison,Katrina Moore,Rachael Waddington,Juliette Novasio,Fiona H Blackhall,Jane Rogan,Elaine Smith,Caroline Dive,Jonathan Tugwood,Ged Brady,Dominic G. Rothwell,Francesca Chemi,Jackie Pierce,Sakshi Gulati,Babu Naidu,Gerald Langman,Simon Trotter,Mary Bellamy,Hollie Bancroft,Amy Kerr,Salma Kadiri,Joanne Webb,Gary Middleton,Madava Djearaman,Dean A. Fennell,Jacqui Shaw,John Le Quesne,David A. Moore,Apostolos Nakas,Sridhar Rathinam,William Monteiro,Hilary Marshall,Louise Nelson,Jonathan Bennett,Joan K. Riley,Lindsay Primrose,Luke Martinson,Girija Anand,Sajid A. Khan,Anita Amadi,Marianne Nicolson,Keith M. Kerr,Shirley Palmer,Hardy Remmen,Joy Miller,Keith Buchan,Mahendran Chetty,Lesley Gomersall,Jason F. Lester,A Edwards,Fiona Morgan,Haydn Adams,Helen Davies,Malgorzata Kornaszewska,Richard Attanoos,Sara Lock,Azmina Verjee,Mairead MacKenzie,Maggie Wilcox,Harriet Bell,Allan Hackshaw,Yenting Ngai,Sean W. Smith,N.H. Gower,Christian H. Ottensmeier,Serena Chee,Benjamin Johnson,Aiman Alzetani,Emily Shaw,Eric Lim,Paulo Loureiro de Sousa,Monica Tavares Barbosa,Alex Bowman,Simon Jordan,Alexandra Rice,H. Raubenheimer,Chiara Proli,Maria Elena Cufari,John Carlo Ronquillo,Angela Kwayie,Harshil Bhayani,Morag Hamilton,Yusura Bakar,Natalie Mensah,Lyn Ambrose,Anand Devaraj,Silviu Buderi,Jonathan Finch,Leire Azcarate,Hema Chavan,Sophie Green,Hillaria Mashinga,Andrew G. Nicholson,Kelvin Lau,Michael Sheaff,Peter Schmid,John Conibear,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Peter Russell,Teresa Light,Tracey Horey,Sarah Danson,Jonathan Bury,John G. Edwards,Jennifer Hill,S. Matthews,Yota Kitsanta,Kim Suvarna,Patricia Fisher,Allah Dino Keerio,Michael Shackcloth,John Gosney,Pieter E. Postmus,Sarah Feeney,Julius Asante-Siaw,Hugo J.W.L. Aerts,Stefan C. Dentro,Christophe Dessimoz +219 more
TL;DR: It is found that HLA LOH occurs in 40% of non-small-cell lung cancers (NSCLCs) and is associated with a high subclonal neoantigen burden, APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity.