Institution
Scuola superiore di Catania
About: Scuola superiore di Catania is a based out in . It is known for research contribution in the topics: Complex network & Graphene. The organization has 103 authors who have published 271 publications receiving 16218 citations.
Papers published on a yearly basis
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TL;DR: Analyzing the reciprocal regulation of Aβ and oxidative stress, that favors Aβ aggregation and toxicity and negatively affects the peptide clearance, may offer novel opportunities for therapeutic intervention.
Abstract: Alzheimer's Disease (AD) is a slow-developing neurodegenerative disorder in which the main pathogenic role has been assigned to β-amyloid protein (Aβ) that accumulates in extracellular plaques. The mechanism of action of Aβ has been deeply analyzed and several membrane structures have been identified as potential mediators of its effect. The ability of Aβ to modify neuronal activity, receptor expression, signaling pathways, mitochondrial function, and involvement of glial cells have been analyzed. In addition, extensive literature deals with the involvement of oxidative stress in Aβ effects. Herein we focus more specifically on the reciprocal regulation of Aβ, that causes oxidative stress, that favors Aβ aggregation and toxicity and negatively affects the peptide clearance. Analysis of this strict interaction may offer novel opportunities for therapeutic intervention. Both common and new molecules endowed with antioxidant properties deserve attention in this regard.
32 citations
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TL;DR: Imidazole‐based compounds previously synthesized in the laboratory were selected and reconsidered as inhibitors of heme oxygenase‐1 obtained from the microsomal fractions of rat spleens and most of tested compounds were good inhibitors with IC50 values in the low micromolar range.
Abstract: Imidazole-based compounds previously synthesized in our laboratory were selected and reconsidered as inhibitors of heme oxygenase-1 obtained from the microsomal fractions of rat spleens. Most of tested compounds were good inhibitors with IC(50) values in the low micromolar range. Compounds were also assayed on membrane-free full-length recombinant human heme oxygenase-1; all tested compounds were unable to interact with human heme oxygenase-1 at 100 μm concentrations with the exception of compounds 11 and 13 that inhibited the enzyme of 54% and 20%, respectively. The binding of the most active compound 11 with heme or heme-conjugated human heme oxygenase-1 was also examined by spectral analyses. When heme was not conjugated to human heme oxygenase-1, compound 11 caused changes in the heme spectrum only at concentration 50-fold (100 μm) higher than that required to inhibit rat heme oxygenase-1; when heme was conjugated to human heme oxygenase-1, compound 11 was able to form a heme-compound 11 complex also at low micromolar concentrations. To obtain information on the binding mode of the tested compounds with enzyme, docking studies and pharmacophore analysis were performed. Template docking results were in agreement with experimental inhibition data and with a structure-based pharmacophoric model. These data may be exploitable to design new OH-1 inhibitors.
31 citations
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TL;DR: In this article, the luminescence-quenching processes limiting quantum efficiency in Er-doped silicon nanocluster light-emitting devices are investigated and identified, and it is found that carrier injection, while needed to excite Er ions through electron-hole recombination, at the same time produces an efficient nonradiative Auger deexcitation with trapped carriers.
Abstract: The luminescence-quenching processes limiting quantum efficiency in Er-doped silicon nanocluster light-emitting devices are investigated and identified. It is found that carrier injection, while needed to excite Er ions through electron-hole recombination, at the same time produces an efficient nonradiative Auger deexcitation with trapped carriers. This phenomenon is studied in detail and, on the basis of its understanding, we propose device structures in which sequential injection of electrons and holes can improve quantum efficiency by avoiding Auger processes.
31 citations
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TL;DR: In this paper, a new ligand, N,N, N′,N′-tetramethylethylenediamine, has been used to grow ZnO nanorods on silicon substrates via a two-step approach.
31 citations
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TL;DR: The experimental findings confirmed that these new PEG-LAA conjugates allow to obtain sterically stable nanocarriers that behave effectively and in a comparable or even better way than the (phospho)lipid PEG derivatives commercially available.
30 citations
Authors
Showing all 103 results
Name | H-index | Papers | Citations |
---|---|---|---|
Vito Latora | 78 | 332 | 35697 |
Luigi Fortuna | 59 | 664 | 12699 |
Jesús Gómez-Gardeñes | 56 | 172 | 12883 |
Francesco Priolo | 51 | 342 | 12692 |
Marco Pavone | 49 | 378 | 8487 |
Daniele F. Condorelli | 45 | 171 | 6091 |
Filippo Giannazzo | 42 | 343 | 5878 |
M. De Domenico | 42 | 80 | 6765 |
Mattia Frasca | 38 | 365 | 5812 |
Vincenzo Nicosia | 36 | 128 | 5937 |
Bruno Pignataro | 34 | 134 | 3664 |
Salvatore Scellato | 33 | 58 | 6587 |
Manlio De Domenico | 30 | 93 | 5074 |
Francesco Saverio Cataliotti | 30 | 139 | 3687 |
Filippo Caruso | 30 | 111 | 4006 |