Institution
Shriners Hospitals for Children - Galveston
Healthcare•Galveston, Texas, United States•
About: Shriners Hospitals for Children - Galveston is a healthcare organization based out in Galveston, Texas, United States. It is known for research contribution in the topics: Burn injury & Lean body mass. The organization has 249 authors who have published 420 publications receiving 15311 citations.
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TL;DR: The results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose homeostasis, and insulin sensitivity in humans, and support the notion that BAT may function as an antidiabetic tissue in humans.
Abstract: Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat Despite a plethora of data concerning the role of BAT in glucose metabolism in rodents, the role of BAT (if any) in glucose metabolism in humans remains unclear To investigate whether BAT activation alters whole-body glucose homeostasis and insulin sensitivity in humans, we studied seven BAT-positive (BAT+) men and five BAT-negative (BAT−) men under thermoneutral conditions and after prolonged (5–8 h) cold exposure (CE) The two groups were similar in age, BMI, and adiposity CE significantly increased resting energy expenditure, whole-body glucose disposal, plasma glucose oxidation, and insulin sensitivity in the BAT+ group only These results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose homeostasis, and insulin sensitivity in humans, and support the notion that BAT may function as an antidiabetic tissue in humans
601 citations
TL;DR: In children with burns, treatment with propranolol during hospitalization attenuates hypermetabolism and reverses muscle-protein catabolism.
Abstract: Background The catecholamine-mediated hypermetabolic response to severe burns causes increased energy expenditure and muscle-protein catabolism. We hypothesized that blockade of β-adrenergic stimulation with propranolol would decrease resting energy expenditure and muscle catabolism in patients with severe burns. Methods Twenty-five children with acute and severe burns (more than 40 percent of total body-surface area) were studied in a randomized trial. Thirteen received oral propranolol for at least two weeks, and 12 served as untreated controls. The dose of propranolol was adjusted to decrease the resting heart rate by 20 percent from each patient's base-line value. Resting energy expenditure and skeletal-muscle protein kinetics were measured before and after two weeks of beta-blockade (or no therapy, in controls). Body composition was measured serially throughout hospitalization. Results Patients in the control group and the propranolol group were similar with respect to age, weight, percentage of tota...
569 citations
TL;DR: The results indicate that the response of net muscleprotein synthesis to consumption of an EAC solution immediately before resistance exercise is greater than that when the solution is consumed after exercise, primarily because of an increase in muscle protein synthesis as a result of increased delivery of amino acids to the leg.
Abstract: The present study was designed to determine whether consumption of an oral essential amino acid-carbohydrate supplement (EAC) before exercise results in a greater anabolic response than supplementa...
523 citations
TL;DR: In severely burned children, hypermetabolism and catabolism remain exaggerated for at least 9 months after injury, suggesting that therapeutic attempts to manipulate the catabolic and hypermetabolic response to severe injury should be continued long after injury.
478 citations
TL;DR: Despite differences in the time course of plasma phenylalanine kinetics and a greater residual IC phenylAlanine concentration, amino acid supplementation acutely stimulated muscle protein synthesis in both young and elderly individuals.
Abstract: We recently demonstrated that muscle protein synthesis was stimulated to a similar extent in young and elderly subjects during a 3-h amino acid infusion. We sought to determine if a more practical ...
471 citations
Authors
Showing all 250 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Helen Fuchs | 1 | 1 | 33 |
| Susana A. Maldonado | 1 | 1 | 12 |
| Abigail A. Forbes | 1 | 1 | 3 |
| Labros S. Sidossis | 1 | 1 | 19 |
| D Jarrar | 1 | 1 | 11 |
| Mary Bernardy | 1 | 1 | 39 |
| Pat Edgar | 1 | 1 | 59 |
| Stephen Williamson | 0 | 1 | 0 |
| Gabriela Kulp | 0 | 1 | 0 |
| Kengo Inagaki | 0 | 1 | 0 |