Institution
Sultan Qaboos University
Education•Muscat, Oman•
About: Sultan Qaboos University is a education organization based out in Muscat, Oman. It is known for research contribution in the topics: Population & Medicine. The organization has 7767 authors who have published 14605 publications receiving 241390 citations. The organization is also known as: SQU.
Papers published on a yearly basis
Papers
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TL;DR: Nivolumab with vaccine is well tolerated as adjuvant therapy and demonstrates immunologic activity with promising survival in high-risk resected melanoma, justifying further study.
Abstract: Purpose: The anti-programmed death-1 (PD-1) antibody nivolumab (BMS-936558) has clinical activity in patients with metastatic melanoma. Nivolumab plus vaccine was investigated as adjuvant therapy in resected stage IIIC and IV melanoma patients. Experimental Design: HLA-A*0201 positive patients with HMB-45, NY-ESO-1, and/or MART-1 positive resected tumors received nivolumab (1 mg/kg, 3 mg/kg, or 10 mg/kg i.v.) with a multi-peptide vaccine (gp100, MART-1, and NY-ESO-1 with Montanide ISA 51 VG) every 2 weeks for 12 doses followed by nivolumab maintenance every 12 weeks for 8 doses. Primary objective was safety and determination of a maximum tolerated dose (MTD). Secondary objectives included relapse-free survival (RFS), overall survival (OS), and immunologic correlative studies. Results: Thirty-three patients were enrolled. Median age was 47 years; 55% were male. Two patients had stage IIIC disease; 31 patients had stage IV disease. Median follow-up was 32.1 months. MTD was not reached. Most common related adverse events (>40%) were vaccine injection site reaction, fatigue, rash, pruritus, nausea, and arthralgias. Five related grade 3 adverse events [hypokalemia (1), rash (1), enteritis (1), and colitis (2)] were observed. Ten of 33 patients relapsed. Estimated median RFS was 47.1 months; median OS was not reached. Increases in CTLA-4 + /CD4 + , CD25 + Treg/CD4 + , and tetramer specific CD8 + T-cell populations were observed with treatment ( P + Treg/CD4 + populations were seen in nonrelapsing patients; PD-L1 tumor status was not significantly associated with RFS. Conclusions: Nivolumab with vaccine is well tolerated as adjuvant therapy and demonstrates immunologic activity with promising survival in high-risk resected melanoma, justifying further study. Clin Cancer Res; 21(4); 712–20. ©2014 AACR .
207 citations
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TL;DR: The significantly very low sugar:acid ratio of the least commonly grown ‘wild’ pomegranate explains its characteristic intense ‘sweet and sour’ taste in comparison with the other cultivars studied.
206 citations
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TL;DR: In this paper, the global stability characteristics of a system of equations modelling the dynamics of additive Hopfield-type neural networks with impulses in the continuous-time case were investigated, and the stability of the system was analyzed.
206 citations
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TL;DR: This review is aimed at comprehensively collating the current available published evidence and clinical correlates of magnesium disorders and its role as a cofactor for more than 300 enzymatic reactions.
Abstract: Magnesium is the fourth most abundant cation in the body. It has several functions in the human body including its role as a cofactor for more than 300 enzymatic reactions. Several studies have shown that hypomagnesemia is a common electrolyte derangement in clinical setting especially in patients admitted to intensive care unit where it has been found to be associated with increase mortality and hospital stay. Hypomagnesemia can be caused by a wide range of inherited and acquired diseases. It can also be a side effect of several medications. Many studies have reported that reduced levels of magnesium are associated with a wide range of chronic diseases. Magnesium can play important therapeutic and preventive role in several conditions such as diabetes, osteoporosis, bronchial asthma, preeclampsia, migraine, and cardiovascular diseases. This review is aimed at comprehensively collating the current available published evidence and clinical correlates of magnesium disorders.
206 citations
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TL;DR: In this paper, the authors presented an approach to stabilize the drilling fluid rheology in HPHT conditions by making use of nanoparticles, which is able to retain the properties over a wide range of operating temperatures and pressure, thus ensuring efficient operation in versatile formations and operating conditions.
205 citations
Authors
Showing all 7855 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard H. Friend | 169 | 1182 | 140032 |
Philippe Froguel | 166 | 820 | 118816 |
Amr Radi | 109 | 504 | 38952 |
Ian G. Stiell | 100 | 477 | 37892 |
Muhammad Farooq | 92 | 1341 | 37533 |
Kadambot H. M. Siddique | 77 | 632 | 22552 |
Gilles J. Guillemin | 70 | 341 | 17566 |
Julia M. Yeomans | 69 | 410 | 18437 |
Muhammad Usman | 61 | 1203 | 24848 |
R.K. O'Nions | 60 | 94 | 14636 |
Mohd Ali Hashim | 60 | 290 | 13382 |
Rema Raman | 59 | 199 | 13921 |
Norbert Nowotny | 56 | 261 | 11623 |
Joydeep Dutta | 55 | 298 | 10792 |
Gunnar Norstedt | 53 | 157 | 10128 |