Institution
Ufuk University
Education•Ankara, Turkey•
About: Ufuk University is a education organization based out in Ankara, Turkey. It is known for research contribution in the topics: Mean platelet volume & Medicine. The organization has 490 authors who have published 960 publications receiving 9815 citations. The organization is also known as: Ufuk Üniversitesi.
Papers published on a yearly basis
Papers
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Duke University1, Uppsala University2, University of Kentucky3, University of Alberta4, Katholieke Universiteit Leuven5, Auckland City Hospital6, Flinders University7, Merck & Co.8, University of Tennessee Health Science Center9, University of Perugia10, University of Freiburg11, University of Barcelona12, Ufuk University13, Henry Ford Health System14, Peking Union Medical College15, Leiden University16, Cleveland Clinic17, Pierre-and-Marie-Curie University18, University of São Paulo19, Kumamoto University20, University of Basel21, University of Chile22, University of Sheffield23, University of Ferrara24, Thomas Jefferson University25, Charles University in Prague26
TL;DR: In patients with acute coronary syndromes, the addition of vorapaxar to standard therapy did not significantly reduce the primary composite end point but significantly increased the risk of major bleeding, including intracranial hemorrhage.
Abstract: In patients with acute coronary syndromes, the addition of vorapaxar to standard therapy did not significantly reduce the primary composite end point but significantly increased the risk of major bleeding, including intracranial hemorrhage. (Funded by Merck; TRACER ClinicalTrials.gov number, NCT00527943.).
690 citations
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TL;DR: These findings expand the phenotypic spectrum of lupus erythematosus in AGS and provide further insight into its disease mechanisms by showing that activation of the innate immune system as a result of inherited defects in nucleic acid metabolism could lead to systemic autoimmunity.
Abstract: Objective
Aicardi-Goutieres syndrome (AGS) is an early-onset encephalopathy resembling congenital viral infection that is characterized by basal ganglia calcifications, loss of white matter, cerebrospinal fluid (CSF) lymphocytosis, and elevated interferon-α levels in the CSF. Studies have shown that AGS is an autosomal-recessive disease linked to mutations in 5 genes, encoding the 3′-repair DNA exonuclease 1 (TREX1), the 3 subunits of ribonuclease H2 (RNASEH2A–C), and sterile alpha motif domain and HD domain–containing protein 1 (SAMHD1). In this study we further characterized the phenotypic spectrum of this disease.
Methods
Clinical and laboratory data were obtained from 26 patients fulfilling the clinical diagnostic criteria for AGS. Genomic DNA was screened for mutations in all 5 AGS genes by direct sequencing, and sera were analyzed for autoantibodies.
Results
In 20 patients with AGS, 20 mutations, 12 of which were novel, were identified in all 5 AGS genes. Clinical and laboratory investigations revealed a high prevalence of features (some not previously described in patients with AGS) that are commonly seen in patients with systemic lupus erythematosus (SLE), such as thrombocytopenia, leukocytopenia, antinuclear antibodies, erythematous lesions, oral ulcers, and arthritis, which were observed in 12 (60%) of 20 patients with AGS. Moreover, the coexistence of AGS and SLE, was for the first time, demonstrated in 2 patients with molecularly proven AGS.
Conclusion
These findings expand the phenotypic spectrum of lupus erythematosus in AGS and provide further insight into its disease mechanisms by showing that activation of the innate immune system as a result of inherited defects in nucleic acid metabolism could lead to systemic autoimmunity.
194 citations
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TL;DR: The reliability and validity of the Turkish version of DN4 questionnaire were found to be high and may help clinicians to identify their neuropathic pain patients accurately in daily clinical practice and research studies.
138 citations
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TL;DR: Results show that OSA syndrome is associated not only with slight hyperhomocysteinemia but also with increased CRP concentrations, and increased plasma concentrations of homocysteine and CRP can be useful in clinical practice to be predictor of long-term prognosis for cardiovascular disease and the treatment of OSA.
133 citations
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TL;DR: Although the most beneficial type of activity and the most relevant patient group for anti- inflammatory benefits are still not clear, studies in elderly and adult people generally support anti-inflammatory effects of physical activity and moderate exercise could be advised to patients with cardiovascular risk such as patients with metabolic syndrome.
Abstract: Since the 19th century, many studies have enlightened the role of inflammation in atherosclerosis, changing our perception of “vessel plaque due to oxidized lipoproteins”, similar to a “rusted pipe”, towards a disease with involvement of many cell types and cytokines with more complex mechanisms. Although “physical activity” and “physical exercise” are two terms with some differences in meaning, compared to sedentary lifestyle, active people have lower cardiovascular risk and lower inflammatory markers. Activities of skeletal muscle reveal “myokines” which have roles in both the immune system and adipose tissue metabolism. In vitro and ex-vivo studies have shown beneficial effects of exercise on inflammation markers. Meanwhile in clinical studies, some conflicting results suggested that type of activity, exercise duration, body composition, gender, race and age may modulate anti-inflammatory effects of physical exercise. Medical data on patients with inflammatory diseases have shown beneficial effects of exercise on disease activity scores, patient well-being and inflammatory markers. Although the most beneficial type of activity and the most relevant patient group for anti-inflammatory benefits are still not clear, studies in elderly and adult people generally support anti-inflammatory effects of physical activity and moderate exercise could be advised to patients with cardiovascular risk such as patients with metabolic syndrome.
129 citations
Authors
Showing all 511 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ahmet Gül | 62 | 507 | 17351 |
John Nyland | 42 | 223 | 5089 |
Mahmut Nedim Doral | 28 | 153 | 2406 |
Gurbuz Erdogan | 22 | 57 | 1583 |
Deniz Evcik | 22 | 60 | 1783 |
Nurşen Düzgün | 22 | 102 | 1803 |
Recai Pabuçcu | 20 | 69 | 1255 |
Orhan Göğüş | 20 | 66 | 1211 |
Hasan Ozan | 20 | 92 | 1208 |
Hakan Omeroglu | 19 | 65 | 1037 |
Erdener Timurkaynak | 19 | 33 | 811 |
Sibel Ertek | 18 | 39 | 913 |
Fikri Icli | 18 | 97 | 1061 |
Nilgün Atakan | 18 | 80 | 1040 |
Aysel Gürler | 17 | 56 | 1493 |