Universidade de Ribeirão Preto

About: Universidade de Ribeirão Preto is a education organization based out in Ribeirão Preto, Brazil. It is known for research contribution in the topics: Medicine & Population. The organization has 840 authors who have published 913 publications receiving 12089 citations. The organization is also known as: University of Ribeirão Preto.

Cucurbitane triterpene glycosides from the roots of Wilbrandia hibiscoides

Abstract: In this study, we isolated and identified cucurbitane triterpene glycosides of Wilbrandia hibiscoides Silva Manso contributing to the phytochemistry of Cucurbitaceae family. Our results show the first phytochemical data of the W. hibiscoides through the identification of three known cucurbitane triterpene glycosides that are chemotaxonomically (chemophenetic) significant constituents in the Cucurbitaceae family, contributing to the chemistry of this species.

Vírus do tumor mamário de camundongo (MMTV) e câncer de mama – associação de causalidade determinante no desfecho clínico

Abstract: Objetiva-se alertar sobre o possivel papel de infeccoes virais causadas pelo virus do tumor mamario de camundongo (MMTV) no desenvolvimento e progressao do câncer (CA) de mama, enfatizando a prevalencia do achado do virus nessa patologia, e sua acao determinante no desfecho clinico carcinogenico. Sendo que, neste trabalho foi realizado um levantamento bibliografico, procurando por producoes cientificas publicadas nos periodicos PubMed, LILACS e SciELO. A partir desse levantamento, foi realizada uma revisao sistematizada, sendo utilizado os artigos cientificos dos ultimos 5 anos, nas versoes portugues, espanhol e ingles. Geralmente, os estudos realizados com Reacao em Cadeia da Polimerase (PCR) e tecnicas de hibridizacao foram levados em consideracao. Assim, foi observada uma prevalencia da carcinogenese mamaria induzida pelo virus do tumor mamario de camundongo (media de 31,6%), quando comparada a ocasiao em que o achado do virus foi positivo, mas nao induzindo tal patologia. Alem de que, quando o achado do virus foi positivo induzindo a carcinogenese, foi evidenciado a inibicao da metastase linfonodal. Dessa forma, o virus do tumor mamario de camundongo se consolida como um fator de risco para o desenvolvimento do CA de mama. Ademais, o achado do virus no câncer de mama foi associado a um melhor prognostico, por inibir a disseminacao sanguinea/linfatica das celulas tumorais. Portanto, a partir possibilidade de que as celulas tumorais possam exibir antigenos virais, estabelece-se um alvo antigenico em potencial, com a promessa de desenvolvimento de tratamentos preventivos para o câncer de mama.

Topical formulation containing chitosan-chamomile microparticles in cutaneous wound healing in rats

Abstract: Objective: The aim of this research was to evaluate the efficacy of a topical formulation containing chitosan-chamomile microparticles in cutaneous healing in rats. Method: Male Wistar rats (n=57) were randomly distributed into three groups: treatment; vehicle; and control. Evaluations were performed on days 2, 7 and 14 after the surgical procedure using skin lesion photography, and histological and biochemical analyses. Results: The results showed that there was no difference in the healing index and in the histological analysis of the inflammatory infiltrate among groups. Fibrogenesis was more significant in the group treated with the test formulation at day 7, and angiogenesis was greater in the vehicle and chamomile groups at day 2. The quantification of hydroxyproline showed a higher amount of collagen in the group treated with chamomile, mainly at day 14, although the histological quantification of collagen showed no difference between the groups. Conclusion: From the results of this study, it can be concluded that the formulation, although it had no effect on the healing time, improved the quality of the cicatricial tissue formed with a greater quantity of fibroblasts and collagen.