Università Campus Bio-Medico

About: Università Campus Bio-Medico is a education organization based out in Rome, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 2829 authors who have published 8519 publications receiving 193689 citations. The organization is also known as: Universita Campus Bio-Medico & Campus Bio-Medico University.

Immune inflammation indicators and implication for immune modulation strategies in advanced hepatocellular carcinoma patients receiving sorafenib

Abstract: // Andrea Casadei Gardini 1 , Emanuela Scarpi 2 , Luca Faloppi 3, 4 , Mario Scartozzi 4 , Nicola Silvestris 5 , Daniele Santini 6 , Giorgio de Stefano 7 , Giorgia Marisi 8 , Francesca V. Negri 9 , Francesco Giuseppe Foschi 10 , Martina Valgiusti 1 , Giorgio Ercolani 11, 12 , Giovanni Luca Frassineti 1 1 Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e Cura dei Tumori (IRST) IRCCS, Meldola, Italy 2 Unit of Biostatistics and Clinical Trials, IRST IRCCS, Meldola, Italy 3 Department of Medical Oncology, Ospedale Generale Provinciale di Macerata ASUR Marche AV3, Macerata, Italy 4 Department of Medical Oncology, University Hospital Cagliari, Cagliari, Italy 5 Medical Oncology Unit, Cancer Institute “Giovanni Paolo II”, Bari, Italy 6 Medical Oncology Department, University Campus Bio-Medico, Via Alvaro del Portillo, Rome, Italy 7 Infectious Diseases and Interventional Ultrasound Unit, D. Cotugno Hospital, Naples, Italy 8 Biosciences Laboratory, IRST IRCCS, Meldola, Italy 9 Medical Oncology Unit, University Hospital, Parma, Italy 10 DPT Internal Medicine, Faenza Hospital, Faenza, AUSL Romagna, Forli, Italy 11 Department of General Surgery, Morgagni-Pierantoni Hospiatal, AUSL Romagna, Forli, Italy 12 Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Correspondence to: Andrea Casadei Gardini, email: andrea.casadei@irst.emr.it Keywords: systemic immune-inflammation index, inflammation, biomarker, hepatocellular carcinoma, neutrophil-to-lymphocyte ratio Received: June 21, 2016 Accepted: August 15, 2016 Published: August 24, 2016 ABSTRACT We evalueted a systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) with the aim to explored their prognostic value in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. 56 advanced HCC patients receiving sorafenib were available for our analysis. Lymphocyte, neutrophil and platelet were measured before beginning of treatment and after one month. Patient with SII ≥ 360 showed lower median PFS (2.6 vs. 3.9 months, P < 0.026) and OS (5.6 vs. 13.9 months, P = 0.027) with respect to patients with SII < 360. NLR ≥ 3 had a lower median PFS (2.6 vs. 3.3 months, P < 0.049) but not OS (5.6 vs. 13.9 months, P = 0.062) than those with NLR < 3. After adjusting for clinical covariates SII and NLR remained an independent prognostic factor for OS. The SII and NLR represent potential prognostic indicator in patients with advanced HCC treated with sorafenib.

Kinetics of Hydrolytic Degradation of PLA

Abstract: The chemical recycling of poly(lactic acid) (PLA) to its monomer is crucial to reduce both the consumption of renewable resources for the monomer synthesis and the environmental impact related to its production and disposal In particular, the production of lactic acid from PLA wastes, rather than from virgin raw materials, it is also possible to achieve considerable primary energy savings The focus of this work is to analyse deeply the PLA hydrolytic decomposition by means of a kinetic model based on two reactions mechanism To this end, new experimental data have been gathered in order to investigate a wider temperature range (from 140 to 180 °C) and to extend the water/PLA ratio up to 50 % of PLA by weight The reported results clearly highlight that more than 95 % of PLA is hydrolyzed to water-soluble lactic acid within 120 min, when it is hydrolyzed within 160–180 °C Furthermore, the kinetic constant is highly influenced by reaction temperature The proposed “two reactions” kinetic mechanism complies satisfactorily with the experimental data under analysis

Remplissage Repair—New Frontiers in the Prevention of Recurrent Shoulder Instability A 2-Year Follow-up Comparative Study

Abstract: Background:An engaging Hill-Sachs lesion is a defect of the humeral head, large enough to cause locking of the humeral head against the anterior corner of the glenoid rim when the arm is at 90° of abduction and more than 30° of external rotation.Hypothesis:When Bankart lesions are associated with engaging Hill-Sachs defects, simultaneous Bankart repair and remplissage provide lower recurrence rates than does Bankart repair alone.Study Design:Cohort study; Level of evidence, 3.Methods:Fifty patients (36 men, 14 women) with combined engaging Hill-Sachs and Bankart lesions were evaluated, before and after arthroscopic management, at a minimum follow-up of 2 years. After imaging and arthroscopic assessment, 25 patients underwent remplissage and Bankart repair, and 25 patients received Bankart repair alone. Patients were evaluated using the UCLA, Constant, and Rowe scores, and range of motion was measured using a goniometer. Postoperatively, all patients underwent magnetic resonance imaging to assess the statu...

Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9

Abstract: The study of endogenous insulin secretion may provide relevant insight into the comparison of the natural history of adult onset latent autoimmune diabetes (LADA) with types 1 and 2 diabetes mellitus. The aim of this study was to compare the results of the C-peptide response to mixed-meal stimulation in LADA patients with different disease durations and subjects with type 2 and adult-onset type 1 diabetes. Stimulated C-peptide secretion was assessed using the mixed-meal tolerance test in patients with LADA (n = 32), type 1 diabetes mellitus (n = 33) and type 2 diabetes mellitus (n = 30). All patients were 30 to 70 years old at disease onset. The duration of diabetes in all groups ranged from 6 months to 10 years. The recruitment strategy was predefined to include at least 10 subjects in the following 3 disease onset categories for each group: 6 to 18 months, 19 months to 5 years and 5 to 10 years. At all time-points of the mixed-meal tolerance test, patients with LADA had a lower stimulated C-peptide response than the type 2 diabetes group and a higher response than the type 1 diabetes group. The same results were found when the peak or area under the C-peptide curve was measured. When the results were stratified by time since disease onset, a similar pattern of residual insulin secretory capacity was observed. The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus.