Institution
Università Campus Bio-Medico
Education•Rome, Italy•
About: Università Campus Bio-Medico is a education organization based out in Rome, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 2829 authors who have published 8519 publications receiving 193689 citations. The organization is also known as: Universita Campus Bio-Medico & Campus Bio-Medico University.
Topics: Population, Medicine, Cancer, Diabetes mellitus, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: VDR is widely expressed in the liver and inflammatory cells of chronic liver disease patients and its expression is negatively associated with the severity of liver histology in both NASH and CHC patients, suggesting that vitamin D/VDR system may play a role in the progression of metabolic and viral chronic liver damage.
197 citations
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TL;DR: This review will provide an overview of the major studies about the link between ischemia, myocardial inflammation and apoptosis during and after CS, with particular regard to the markers and methods for apoptosis detection.
Abstract: Cardiac surgery (CS), in particular cardiopulmonary bypass and cardioplegia, have been reported to trigger myocardial inflammation and apoptosis. This surgery-related inflammatory reaction appears to be of extreme complexity with regard to its molecular, cellular and tissue mechanisms. Both experimental and clinical studies have ascertained the role of several hormonal mediators, mitochondria, cardioplegia and extracorporeal circulation temperature, apoptosis and even genetic modulators of damage. However, the correlations between these factors in vivo and post-surgery outcome and prognosis have not yet been systematically investigated. In animal models of myocardial cardioplegia and/or ischemia-reperfusion, experimental drugs such as antioxidants have been documented to provide amelioration of post-intervention cardiac performance and reduction of apoptosis suggesting the possibility of new therapeutic strategies. However, these findings have been only partially confirmed in humans. Moreover, markers for the differential detection of early and late phases of apoptosis are subjects of intense investigations. This review will provide an overview of the major studies about the link between ischemia, myocardial inflammation and apoptosis during and after CS, with particular regard to the markers and methods for apoptosis detection.
196 citations
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TL;DR: The midterm angiographic results of radial artery grafts used for myocardial revascularization are excellent, and the correct surgical indication is essential.
195 citations
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TL;DR: In this article, a brain clearing agent (2,2′-thiodiethanol; TDE) is proposed to overcome the limitations due to tissue light scattering in the central nervous system.
Abstract: Extensive mapping of neuronal connections in the central nervous system requires high-throughput µm-scale imaging of large volumes. In recent years, different approaches have been developed to overcome the limitations due to tissue light scattering. These methods are generally developed to improve the performance of a specific imaging modality, thus limiting comprehensive neuroanatomical exploration by multi-modal optical techniques. Here, we introduce a versatile brain clearing agent (2,2′-thiodiethanol; TDE) suitable for various applications and imaging techniques. TDE is cost-efficient, water-soluble and low-viscous and, more importantly, it preserves fluorescence, is compatible with immunostaining and does not cause deformations at sub-cellular level. We demonstrate the effectiveness of this method in different applications: in fixed samples by imaging a whole mouse hippocampus with serial two-photon tomography; in combination with CLARITY by reconstructing an entire mouse brain with light sheet microscopy and in translational research by imaging immunostained human dysplastic brain tissue.
194 citations
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TL;DR: The aim of this review is to summarize the available evidence on curcumin's effectiveness in pulmonary diseases, including lung cancer, and to provide the perspective on future research with cur cumin so as to improve its pharmacological effects, as well as provide additional evidence of curcuron's efficacy in the treatment of pulmonary diseases.
194 citations
Authors
Showing all 2872 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert J. Motzer | 121 | 883 | 80129 |
Nicola Maffulli | 115 | 1570 | 59548 |
Bernard Escudier | 96 | 664 | 53523 |
Paolo Maria Rossini | 94 | 680 | 43935 |
Franco Mandelli | 89 | 720 | 33262 |
Matteo Cesari | 88 | 611 | 35197 |
Ana M. Valdes | 84 | 334 | 26627 |
Mauro Maccarrone | 80 | 533 | 22514 |
Patrizio Pasqualetti | 75 | 321 | 17042 |
Tiziana Bisogno | 75 | 130 | 19445 |
Massimo Inguscio | 74 | 427 | 21507 |
Guido Costamagna | 72 | 656 | 19050 |
Alberto Zangrillo | 70 | 539 | 21474 |
Antonio Abbate | 70 | 507 | 17365 |
Giovanni Landoni | 69 | 611 | 17481 |