Institution
Università Campus Bio-Medico
Education•Rome, Italy•
About: Università Campus Bio-Medico is a education organization based out in Rome, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 2829 authors who have published 8519 publications receiving 193689 citations. The organization is also known as: Universita Campus Bio-Medico & Campus Bio-Medico University.
Topics: Population, Medicine, Cancer, Diabetes mellitus, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: The results are consistent with complex interactions between genetic (reeler genotype) and epigenetic (prenatal exposure to CPF-O) factors and points to reciprocal adaptations within cholinergic and dopaminergic systems during development.
Abstract: Introduction
Epidemiological and experimental studies support a link between genetic and epigenetic factors in vulnerability to develop enduring neurobehavioral alterations. We studied the interplay between genetic vulnerability and the prenatal exposure to a neurotoxic compound. Chlorpyrifos, a potent and reversible acetylcholinesterase blocker used as a pesticide, and the “reeler” mouse, lacking the extracellular-matrix protein Reelin, were used.
73 citations
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TL;DR: The presence of easily harvestable stem cell population within adult human hamstring tendons was demonstrated, and age-related variations in human TSCs affect the number of isolated cells and their self-renewal potential, while multi-potency assays are not influenced by tendon ageing.
Abstract: Purpose
The present study evaluated the presence of stem cells in hamstring tendons from adult subjects of different ages. The aim was to isolate, characterize and expand these cells in vitro, and to evaluate whether cell activities are influenced by age.
73 citations
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TL;DR: An arthroscopic rotator cuff repair technique which uses suture bridges to improve pressurized contact area and mean footprint pressure and maximizes the strength of the repair and provides a barrier preventing penetration of synovial fluid into the healing area of tendon and bone.
Abstract: Background
With advances in arthroscopic surgery, many techniques have been developed to increase the tendon-bone contact area, reconstituting a more anatomic configuration of the rotator cuff footprint and providing a better environment for tendon healing.
73 citations
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TL;DR: The essential role of innate and adaptive immune response in RCC proliferation, invasion and metastasis and the relationship between tumor‐associated immune cells and the response to targeted agents approved for the treatment of metastatic RCC are overviewed.
Abstract: Angiogenesis and immunosuppression work hand-in-hand in the renal cell carcinoma (RCC) microenvironment. Tumor growth is associated with impaired antitumor immune response in RCC, which involves T cells, natural killer cells, dendritic cells (DCs) and macrophages. Vascular endothelial growth factor receptor (VEGFR), such as sorafenib, sunitinib, pazopanib and axitinib, and mammalian target of rapamycin (mTOR) inhibitors, such as temsirolimus and everolimus, do exert both antiangiogenic and immunomodulatory functions. Indeed, these agents affect neutrophil migration, as well as T lymphocyte-DC cross-talk, DC maturation and immune cell metabolism and reactivity. In this review, we overview the essential role of innate and adaptive immune response in RCC proliferation, invasion and metastasis and the relationship between tumor-associated immune cells and the response to targeted agents approved for the treatment of metastatic RCC.
73 citations
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TL;DR: NGF plays a major role during the epithelial healing process by promoting migration, a process that is accelerated by cell spreading.
Abstract: PURPOSE Nerve growth factor (NGF) is a neuropeptide essential for the development, survival, growth, and differentiation of corneal cells. Its effects are mediated by both TrkA and p75 receptors. Clinically relevant use of NGF was introduced to treat neurotrophic ulcerations in patients. Herein, we examine the mechanisms by which NGF enhances epithelial wound healing both in vivo and in vitro. METHODS An animal model using adult hens was implemented for the in vivo experiments. Laser ablation keratectomy was performed and animals were observed for up to 7 days. Epithelial healing was measured with fluorescein. In addition, proliferation was measured using BrdU incorporation and both TrkA and matrix metalloprotease-9 (MMP-9) expression were measured by immunohistochemistry (IHC) and Western blot (WB). In vitro experiments were carried out with telomerase-immortalized human corneal epithelial cells (HCLE). The rate of proliferation was measured using a colorimetric assay and BrdU incorporation. Real-time migration was evaluated with an inverted microscope. MMP-9 expression was evaluated by immunocytochemistry (ICC), WB, zymography, and RT-PCR. Finally, beta-4 integrin (β4) expression was assessed by ICC and WB. RESULTS Faster epithelial healing was observed in NGF-treated corneas compared with controls (P < 0.01). These corneas showed increased proliferation, TrkA upregulation, and enhanced MMP-9 presence (P < 0.01). In vitro, faster spreading and migration were observed in response to NGF (P < 0.01). Enhanced proliferation, as well as enhanced TrkA and MMP-9 expression, and decreased β4 levels were observed after adding NGF (P < 0.01). CONCLUSIONS NGF plays a major role during the epithelial healing process by promoting migration, a process that is accelerated by cell spreading. This effect is mediated by both the upregulation of MMP-9 and cleavage of β4 integrin.
73 citations
Authors
Showing all 2872 results
Name | H-index | Papers | Citations |
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Robert J. Motzer | 121 | 883 | 80129 |
Nicola Maffulli | 115 | 1570 | 59548 |
Bernard Escudier | 96 | 664 | 53523 |
Paolo Maria Rossini | 94 | 680 | 43935 |
Franco Mandelli | 89 | 720 | 33262 |
Matteo Cesari | 88 | 611 | 35197 |
Ana M. Valdes | 84 | 334 | 26627 |
Mauro Maccarrone | 80 | 533 | 22514 |
Patrizio Pasqualetti | 75 | 321 | 17042 |
Tiziana Bisogno | 75 | 130 | 19445 |
Massimo Inguscio | 74 | 427 | 21507 |
Guido Costamagna | 72 | 656 | 19050 |
Alberto Zangrillo | 70 | 539 | 21474 |
Antonio Abbate | 70 | 507 | 17365 |
Giovanni Landoni | 69 | 611 | 17481 |