Institution
Università Campus Bio-Medico
Education•Rome, Italy•
About: Università Campus Bio-Medico is a education organization based out in Rome, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 2829 authors who have published 8519 publications receiving 193689 citations. The organization is also known as: Universita Campus Bio-Medico & Campus Bio-Medico University.
Topics: Population, Medicine, Cancer, Diabetes mellitus, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: Current knowledge on the complex effects of type 2 diabetes mellitus on bone including effects on bone cells, bone material properties and other endocrine systems that subsequently affect bone are summarized and a model identifying factors that may contribute to poor bone quality and increased bone fragility in T2DM is concluded.
Abstract: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a result of our aging society, high caloric intake and sedentary lifestyle. Besides the well-known complications of T2DM on the cardiovascular system, the eyes, kidneys and nerves, bone strength is also impaired in diabetic patients. Patients with T2DM have a 40-70% increased risk for fractures, despite having a normal to increased bone mineral density, suggesting that other factors besides bone quantity must account for increased bone fragility. This review summarizes the current knowledge on the complex effects of T2DM on bone including effects on bone cells, bone material properties and other endocrine systems that subsequently affect bone, discusses the effects of T2DM medications on bone and concludes with a model identifying factors that may contribute to poor bone quality and increased bone fragility in T2DM.
80 citations
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TL;DR: A review of clinical, functional outcomes, and complications after open and minimally invasive surgery for Achilles tendon ruptures found the range of motion was significantly greater after percutaneous repair than open surgery.
Abstract: Introduction: This review provides a comprehensive description of clinical, functional outcomes, and complications after open and minimally invasive surgery for Achilles tendon ruptures. Sources of data: We systematically searched Medline (PubMED), EMBASE, CINHAL, Cochrane, Sports Discus and Google scholar databases using the combined keywords ‘open repair’, ‘percutaneous surgery’, ‘minimally invasive surgery ’‘ Achilles tendon rupture’, ‘complications’, ‘infections’, ‘wound disorders’ to identify articles published in English, Spanish, French and Italian. Areas of agreement: Twelve studies fulfilled our inclusion criteria. Six studies were retrospective, five were randomized controlled trials and one was a prospective investigation. Of a total of 781 patients, 375 underwent open repair and 406 percutaneous surgery. Different procedures were performed for open and minimally invasive repair. Areas of controversy: The range of motion was significantly greater after percutaneous repair than open surgery. The number of complications that occurred after open surgery was higher than after minimally invasive surgery.
80 citations
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TL;DR: In this article, the function of autophagy in neurodegeneration that has been induced by acute focal cerebellar lesions was examined and the authors provided morphological, ultrastructural, and biochemical evidence that lesions in a cerebellal hemisphere activate autophagia in axotomized precerebellar neurons.
Abstract: Autophagy is the evolutionarily conserved degradation and recycling of cellular constituents. In mammals, autophagy is implicated in the pathogenesis of many neurodegenerative diseases. However, its involvement in acute brain damage is unknown. This study addresses the function of autophagy in neurodegeneration that has been induced by acute focal cerebellar lesions. We provide morphological, ultrastructural, and biochemical evidence that lesions in a cerebellar hemisphere activate autophagy in axotomized precerebellar neurons. Through time course analyses of the apoptotic cascade, we determined mitochondrial dysfunction to be the early trigger of degeneration. Further, the stimulation of autophagy by rapamycin and the employment of mice with impaired autophagic responses allowed us to demonstrate that autophagy protects from damage promoting functional recovery. These findings have therapeutic significance, demonstrating the potential of pro-autophagy treatments for acute brain pathologies, such as stroke and brain trauma.
80 citations
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TL;DR: The results indicate that D 310 abnormalities are detectable in cytology specimens from patients with cancer and support the notion that D310 analysis may represent a new molecular tool for cancer detection.
80 citations
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TL;DR: Platelet count does not predict unprovoked major or minor bleeding in cirrhotic patients, and prothrombin time-international normalized ratio was slightly higher in patients with overall or major bleeding.
80 citations
Authors
Showing all 2872 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert J. Motzer | 121 | 883 | 80129 |
Nicola Maffulli | 115 | 1570 | 59548 |
Bernard Escudier | 96 | 664 | 53523 |
Paolo Maria Rossini | 94 | 680 | 43935 |
Franco Mandelli | 89 | 720 | 33262 |
Matteo Cesari | 88 | 611 | 35197 |
Ana M. Valdes | 84 | 334 | 26627 |
Mauro Maccarrone | 80 | 533 | 22514 |
Patrizio Pasqualetti | 75 | 321 | 17042 |
Tiziana Bisogno | 75 | 130 | 19445 |
Massimo Inguscio | 74 | 427 | 21507 |
Guido Costamagna | 72 | 656 | 19050 |
Alberto Zangrillo | 70 | 539 | 21474 |
Antonio Abbate | 70 | 507 | 17365 |
Giovanni Landoni | 69 | 611 | 17481 |