Showing papers by "University of Cagliari published in 1971"
TL;DR: In mice made aggressive by prolonged isolation, there is a decrease in brain serotonin turnover, while increased aggressiveness has been noted in cats and rats given p-chlorophenylalanine (PCPA), which inhibits serotonin synthesis.
Abstract: THERE is some doubt about the role of brain serotonin in aggression. In mice made aggressive by prolonged isolation, there is a decrease in brain serotonin turnover1, while increased aggressiveness has been noted in cats2 and rats3 given p-chlorophenylalanine (PCPA), which inhibits serotonin synthesis4, although the experiments with cats2 were not confirmed later5. Dominguez and Longo6 reported that PCPA attenuates irritability and viciousness in rats with septal lesions, and Welch and Welch7 observed decreased aggressiveness in isolated mice given PCPA. The explanation for these contradictory results may be that different models of aggression are not mediated through the same areas of the brain or by the same biochemical mechanisms.
167 citations
TL;DR: In this paper, Gamma-hydroxybutyrate (GHB) was shown to increase the dopamine synthesis rate in the basal ganglia of the rat and caudate nucleus of the rabbit at a rate which greatly exceeded the normal synthesis rate of the amine in these species.
Abstract: — Gamma-hydroxybutyrate administration produces a marked selective increase of brain dopamine in different animal species. Following γ-hydroxybutyrate administration, dopamine accumulated in the basal ganglia of the rat and in the caudate nucleus of the rabbit at a rate which greatly exceeded the normal synthesis rate of the amine in these species. Dopamine accumulation was prevented by α-methyltyrosine. These data indicate that γ-hydroxybutyrate stimulates dopamine synthesis. In addition, γ-hydroxybutyrate increased the homovanillic acid level in the rat basal ganglia to a maximum of about 300 per cent of the normal level indicating that γ-hydroxybutyrate inhibits neither monoamine oxidase nor catechol O-methyltransferase in vivo. The possible mechanisms of dopamine accumulation following γ-hydroxybutyrate administration are discussed.
61 citations
TL;DR: The relation of reduced sexual sensitivity produced by pargyline to accumulation of brain serotonin is investigated, and whether the effect could be prevented by p-chlorophenyl-alanine (PCPA), a potent inhibitor of serotonin biosynthesis12.
Abstract: Reversal of Pargyline-induced Inhibition of Sexual Behaviour in Male Rats by p-Chlorophenylalanine
46 citations
TL;DR: The results suggest that the septum might be an important relay of the central cholinergic pathways in the brain and the effects of septal lesions on the level of brain ACh are investigated.
45 citations
TL;DR: In this article, the analysis of the kinetics of the thermoluminescence process is faced with a new method, which allows us to verify whether the forms of the kinetic equations are really suitable to represent the shape of the observed glow peaks.
34 citations
TL;DR: Examination of the fundi with the ophthalmo scope, the slit lamp, and the Goldmann lens revealed segmented, yellowish-white plaques scattered along the main arterial branches, often in a ring-like ar rangement, demonstrating the classic periarterial deposition.
29 citations
TL;DR: In this article, the preparation of new mixed ligand complexes of 3,3′-diaminodipropylamine (dpt) and ethylenediamine (en) with copper(II) of the type [Cu(dpt)(L)]X2, where L is en, tn; X is Cl−1, Br−, I−, ClO4−) is described and their infrared, electronic spectra and magnetic susceptibilities are reported.
19 citations
TL;DR: In this paper, a white, crystalline, diamagnetic complex [AgT]NO3 was obtained from the reaction between AgNO3 and T. The mechanism is dominated by a preliminary hydrolysis equilibrium.
17 citations
TL;DR: In this paper, the magnetic susceptibility of some AIIBIII2CVI4 defect tetrahedral compounds was measured at room temperature and the experimental data were analyzed along the line of previous theoretical considerations in which the Langevin and the Van Vleck magnetic susceptibility components are described, respectively, in terms of atomic and bonding parameters of the compounds considered.
Abstract: The magnetic susceptibility of some AIIBIII2CVI4 defect tetrahedral compounds was measured at room temperature. The experimental data are analyzed along the line of previous theoretical considerations in which the Langevin and the Van Vleck magnetic susceptibility components are described, respectively, in terms of atomic and bonding parameters of the compounds considered. A comparison of the experimental results with those of ANB8–N normal tetrahedral compounds can be made by introducing the number of bonds per formula as a normalization factor.
Die magnetische Suszeptibilitat von einigen tetraedrischen AIIBIII2CVI4-Defektstruktur-verbindungen wurde bei Raumtemperatur gemessen. Die experimentellen Werte werden an Hand fruherer theoretischer Betrachtungen ausgewertet, in denen die magnetischen Suszeptibilitatskomponenten von Langevin und von Van Vleck mit Atom- und Bindungsparametern der behandelten Verbindung beschrieben werden. Ein Vergleich der experimentellen Ergebnisse mit denen von ANB8–N tetraedrischen Normalverbindungen kann durch die Einfuhrung der Zahl der Bindung pro Formel als Normierungsfaktor durchgefuhrt werden.
17 citations
TL;DR: In this article, the kinetics of paste, bottle, and ball-mill hydration of 3CaO SiO2 and the effects of additions of electrolytes and alcohols were studied.
Abstract: The kinetics of paste, bottle, and ball-mill hydration of 3CaO SiO2 and the effects of additions of electrolytes and alcohols were studied. Paste and bottle hydrations proceed through periods of induction, acceleration, and decay. If 3CaO SiO2 is hydrated in an excess of H2O, as in bottle hydration, the reaction rate is lower than that for paste hydration. The ball-mill hydration rate is much the highest and is controlled by the removal of the hydrate layer coating the 3CaO SiO2 particles. Electrolytes always accelerate and alcohols retard the reaction rate. Experimental results are discussed with reference to modern theories of the 3CaO SiO2 hydration mechanism.
15 citations
TL;DR: It has been demonstrated that the amount of the 300-nm absorbing compound is proportional to the initial TMA concentration and to the oxygen concentration, while is independent of the concentration of TMA-Cu II complex.
TL;DR: In this paper, the authors investigated the thermoluminescence of ten textile fibres above liquid N 2 temperature and found that the glow peak peculiarities are mainly due to structural defects or chemical impurities.
TL;DR: The oxidative deamination of D-HCS by D-aspartate oxidase is investigated to have further indications that enzymes active on glutamate also may be active on HCS, and shows the same analogy with aspartic acid that HCS shows with glutamic acid.
TL;DR: In this article, pure water and HCl aqueous solutions 1N and 4.3N at 25°C were investigated, and the radial distribution functions (RDF) of the solutions show the same general feature as the water RDF; the first peak becomes however broader and shifts to larger R values as expected because of OHCl − interaction.
TL;DR: In this paper, the dispersive approach is applied to the reaction 4He(γ, d)d and deduce the transition matrix element, which includes final state interactions, as a solution of an Omnes-Muskhelishvili integral equation.
TL;DR: The total photo-absorption cross sections of 28 Si and 32 S have been calculated in a 1p−1h continuum shell model approximation using the eigenchannel reaction theory.
TL;DR: In this article, an explanation of the non-linear dependence of the energy gap on the composition of substitutional solid solutions, considering different types of substitution, is given, and the nonlinearity is tightly connected with some characteristic energetic parameters and with the ionic radii ratio of the solution components.
Abstract: An explanation is given of the non-linear dependence of the energy gap on the composition of substitutional solid solutions, considering different types of substitution. It is found that the non-linearity is tightly connected with some characteristic energetic parameters and with the ionic radii ratio of the solution components.
Une explication de la variation non-lineaire en fonction de la composition de l'energie de la bande interdite des solutions solides substitutionnelles est suggeree par une analyse comparative des differents types de substitution. On remarque que la non-lineairite est reliee a quelques caracteristiques parametres energetiques et aux rapports des rayons ioniques des elements qui constituent la solution.
TL;DR: In this article, an apparatus was set up for ebullioscopy based on a platinum resistance thermometer which permits absolute temperature evaluation with a high degree of precision in all concentration fields.
TL;DR: The fact that unless capsid precursors previously synthesized in a drug-free medium are available, low concentrations of p-fluorophenylalanine (FPA), an inhibitor of proteins synthesis, prevent the incorporation of viral RNA in complete infectious virus provides the possibility of establishing whether or not guanidine acts directly on capsid Precursors.
TL;DR: In this paper, a rilevante pool metabolico intracellulare of aminoacidi is proposed, in which cellule concentrano gli aminoacidia dai fluidi extracellulari and sanno mantenere una differenza di concentrazione tra ambiente intraceLLulare and extracel. lulare per questi composti.
Abstract: Tutti i tessuti posseggono un rilevante pool intracellulare di aminoacidi. Le cellule concentrano gli aminoacidi dai fluidi extracellulari e sanno mantenere una differenza di concentrazione tra ambiente intracellulare ed extracel. lulare per questi composti. Lo stato di organizzazione di questo pool metabolico intracellulare non è ancor oggi esattamente definito: è stato proposto che gli aminoacidi da cui è costituito siano liberi in soluzione, che sia spazialmente o chimicamente compartimentalizzato, che una delle sue /unzioni (od una /unzione di uno dei suoi possibili componenti) sia queUa di un obbligatorio precursore per la sintesi proteica 16, 18, 20, 30, 36
TL;DR: La scarsa incorporazione di precursori dello ARN in cellule infette da poliovirus ed incubate a 41,5°C è dovuta ad una inibizione della sintesi dell'ARN virale più che non ad uni sua digestione ad opera di nucleasi.
Abstract: La scarsa incorporazione di precursori dello ARN in cellule infette da poliovirus ed incubate a 41,5°C e dovuta ad una inibizione della sintesi dello ARN virale piu che non ad una sua digestione ad opera di nucleasi.
TL;DR: In this paper, the authors investigated the standard error when a variable quantity is measured by points and used a generalized Γ distribution which accounts for the probability that some linear combinations of square fluctuations lie in a given interval.